Difference between revisions of "Elotuzumab (Empliciti)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert.<ref name=insert></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert.<ref name=insert></ref> | ||
| − | ==Diseases for which it is | + | ==Diseases for which it is established== |
*[[Multiple myeloma]] | *[[Multiple myeloma]] | ||
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | *11 | + | *2015-11-30: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm474719.htm FDA approved] to be used in combination with [[Lenalidomide (Revlimid) | lenalidomide]] and [[Dexamethasone (Decadron) | dexamethasone]] for the treatment of patients with [[Multiple myeloma | multiple myeloma]] who have received one to three prior therapies. ''(Based on ELOQUENT-2)'' |
| − | *11 | + | *2018-11-06: Approved in combination with pomalidomide and dexamethasone for the treatment of adult patients with [[multiple myeloma]] who have received at least two prior therapies including lenalidomide and a proteasome inhibitor. ''(Based on ELOQUENT-3)'' |
==History of changes in EMA indication== | ==History of changes in EMA indication== | ||
| − | * | + | *2016-05-11: Initial authorization |
==Also known as== | ==Also known as== | ||
*'''Code names:''' BMS-901608, HuLuc63, PDL063, PDL-063 | *'''Code names:''' BMS-901608, HuLuc63, PDL063, PDL-063 | ||
Revision as of 21:35, 4 May 2023
General information
Class/mechanism: Humanized IgG1 monoclonal antibody which targets SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7). SLAMF7 is a protein which is expressed on myeloma cells, Natural Killer cells, plasma cells, and expressed at lower levels on certain immune cell subsets of differentiated cells. Elotuzumab facilitates antibody-dependent cellular cytotoxicity (ADCC) between myeloma cells and Natural Killer cells. The antigen target of elotuzumab may also be known as CS1 (CD2 subset 1, CRACC, SLAMF7).[1][2][3][4]
[5]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert.[1]
Diseases for which it is established
Patient drug information
History of changes in FDA indication
- 2015-11-30: FDA approved to be used in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. (Based on ELOQUENT-2)
- 2018-11-06: Approved in combination with pomalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor. (Based on ELOQUENT-3)
History of changes in EMA indication
- 2016-05-11: Initial authorization
Also known as
- Code names: BMS-901608, HuLuc63, PDL063, PDL-063
- Generic name: anti-CS1 monoclonal antibody HuLuc63
- Brand name: Empliciti