Difference between revisions of "Subependymal giant cell astrocytoma"
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!style="width: 20%"|Comparator | !style="width: 20%"|Comparator | ||
!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
| + | |- | ||
| + | |[https://doi.org/10.1056/nejmoa1001671 Krueger et al. 2010 (CCHMC 06-07-50)] | ||
| + | |2007-2008 | ||
| + | | style="background-color:#91cf61" |Phase 1/2 (RT) | ||
| + | | style="background-color:#d3d3d3" | | ||
| + | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
|[https://doi.org/10.1016/s0140-6736(12)61134-9 Franz et al. 2012 (EXIST-1)] | |[https://doi.org/10.1016/s0140-6736(12)61134-9 Franz et al. 2012 (EXIST-1)] | ||
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===References=== | ===References=== | ||
| + | #'''CCHMC 06-07-50:''' Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11. [https://doi.org/10.1056/nejmoa1001671 link to original article] [https://pubmed.ncbi.nlm.nih.gov/21047224/ PubMed] NCT00411619 | ||
# '''EXIST-1:''' Franz DN, Belousova E, Sparagana S, Bebin EM, Frost M, Kuperman R, Witt O, Kohrman MH, Flamini JR, Wu JY, Curatolo P, de Vries PJ, Whittemore VH, Thiele EA, Ford JP, Shah G, Cauwel H, Lebwohl D, Sahmoud T, Jozwiak S. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013 Jan 12;381(9861):125-32. Epub 2012 Nov 14. Erratum in: Lancet. 2013 Jan 12;381(9861):116. [https://doi.org/10.1016/s0140-6736(12)61134-9 link to original article] '''contains protocol''' [https://pubmed.ncbi.nlm.nih.gov/23158522/ PubMed] NCT00789828 | # '''EXIST-1:''' Franz DN, Belousova E, Sparagana S, Bebin EM, Frost M, Kuperman R, Witt O, Kohrman MH, Flamini JR, Wu JY, Curatolo P, de Vries PJ, Whittemore VH, Thiele EA, Ford JP, Shah G, Cauwel H, Lebwohl D, Sahmoud T, Jozwiak S. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013 Jan 12;381(9861):125-32. Epub 2012 Nov 14. Erratum in: Lancet. 2013 Jan 12;381(9861):116. [https://doi.org/10.1016/s0140-6736(12)61134-9 link to original article] '''contains protocol''' [https://pubmed.ncbi.nlm.nih.gov/23158522/ PubMed] NCT00789828 | ||
Revision as of 12:33, 18 June 2022
| Section editor | |
|---|---|
 |
Seema Nagpal, MD Stanford University Palo Alto, CA |
If you are looking for other subtypes of brain cancer, please go to the CNS cancers category page.
1 regimens on this page
1 variants on this page
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All lines of therapy
Everolimus monotherapy
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Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Krueger et al. 2010 (CCHMC 06-07-50) | 2007-2008 | Phase 1/2 (RT) | ||
| Franz et al. 2012 (EXIST-1) | 2009-NR in abstract | Phase 3 (E-RT-esc) | Placebo | Superior confirmed response rate |
Targeted therapy
- Everolimus (Afinitor) as follows:
- Starting dose: 4.5 mg/m2 PO once per day
- Goal dose: Titrated to achieve blood trough concentrations of 5 to 15 ng/mL
Continued indefinitely
References
- CCHMC 06-07-50: Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11. link to original article PubMed NCT00411619
- EXIST-1: Franz DN, Belousova E, Sparagana S, Bebin EM, Frost M, Kuperman R, Witt O, Kohrman MH, Flamini JR, Wu JY, Curatolo P, de Vries PJ, Whittemore VH, Thiele EA, Ford JP, Shah G, Cauwel H, Lebwohl D, Sahmoud T, Jozwiak S. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013 Jan 12;381(9861):125-32. Epub 2012 Nov 14. Erratum in: Lancet. 2013 Jan 12;381(9861):116. link to original article contains protocol PubMed NCT00789828