Difference between revisions of "Light-chain (AL) amyloidosis - historical"
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| style="background-color:#d73027" |Inferior OS | | style="background-color:#d73027" |Inferior OS | ||
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| − | |2. Melphalan, Prednisone, Colchicine | + | |2. [[#MP_.26_Colchicine_88|Melphalan, Prednisone, Colchicine]] |
| style="background-color:#d73027" |Inferior OS | | style="background-color:#d73027" |Inferior OS | ||
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| − | |2. Melphalan, Prednisone, Colchicine | + | |2. [[#MP_.26_Colchicine_99|Melphalan, Prednisone, Colchicine]] |
| style="background-color:#ffffbf" |Seems not superior | | style="background-color:#ffffbf" |Seems not superior | ||
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Revision as of 13:04, 19 March 2022
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? Please go to the main light-chain (AL) amyloidosis regimen page to find other regimens.
2 regimens on this page
2 variants on this page
|
First-line therapy (including transplant ineligible)
Colchicine monotherapy
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Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Kyle et al. 1985 | NR | Randomized (E-switch-ooc) | MP | Seems not superior |
| Cohen et al. 1987 | 1976-1983 | Non-randomized | ||
| Kyle et al. 1997 | 1982-1992 | Phase 3 (C) | 1. MP | Inferior OS |
| 2. Melphalan, Prednisone, Colchicine | Inferior OS |
Of historic interest.
Chemotherapy
References
- Kyle RA, Greipp PR, Garton JP, Gertz MA. Primary systemic amyloidosis: comparison of melphalan/prednisone versus colchicine. Am J Med. 1985 Dec;79(6):708-16. link to original article PubMed
- Cohen AS, Rubinow A, Anderson JJ, Skinner M, Mason JH, Libbey C, Kayne H. Survival of patients with primary (AL) amyloidosis: colchicine-treated cases from 1976 to 1983 compared with cases seen in previous years (1961 to 1973). Am J Med. 1987 Jun;82(6):1182-90. link to original article PubMed
- Kyle RA, Gertz MA, Greipp PR, Witzig TE, Lust JA, Lacy MQ, Therneau TM. A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. N Engl J Med. 1997 Apr 24;336(17):1202-7. link to original article PubMed
Melphalan & Prednisone (MP)
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MP: Melphalan & Prednisone
Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Kyle et al. 1978 | NR | Randomized (E-esc) | Placebo | Longer time on treatment |
| Kyle et al. 1985 | NR | Randomized (E-switch-ooc) | Colchicine | Seems not superior |
| Kyle et al. 1997 | 1982-1992 | Phase 3 (C) | 1. Colchicine | Superior OS |
| 2. Melphalan, Prednisone, Colchicine | Seems not superior |
Of historic interest.
Chemotherapy
References
- Kyle RA, Greipp PR. Primary systemic amyloidosis: comparison of melphalan and prednisone versus placebo. Blood. 1978 Oct;52(4):818-27. link to original article PubMed
- Kyle RA, Greipp PR, Garton JP, Gertz MA. Primary systemic amyloidosis: comparison of melphalan/prednisone versus colchicine. Am J Med. 1985 Dec;79(6):708-16. link to original article PubMed
- Kyle RA, Gertz MA, Greipp PR, Witzig TE, Lust JA, Lacy MQ, Therneau TM. A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. N Engl J Med. 1997 Apr 24;336(17):1202-7. link to original article PubMed