Difference between revisions of "CNS lymphoma - null regimens"
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|[https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(10)70229-1/fulltext Thiel et al. 2010 (G-PCNSL-SG-1)] | |[https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(10)70229-1/fulltext Thiel et al. 2010 (G-PCNSL-SG-1)] | ||
|2000-2009 | |2000-2009 | ||
| − | |style="background-color:#1a9851"|Phase | + | |style="background-color:#1a9851"|Phase 3 (E-de-esc) |
|[[CNS_lymphoma#Whole_brain_irradiation|Whole-brain irradiation]] | |[[CNS_lymphoma#Whole_brain_irradiation|Whole-brain irradiation]] | ||
|style="background-color:#91cf61"|Inconclusive whether non-inferior OS | |style="background-color:#91cf61"|Inconclusive whether non-inferior OS | ||
Revision as of 15:02, 12 February 2022
The purpose of this page is to provide references to "null therapy" such as placebo and observation. While not clinically relevant, these references provide further insight into the historical development of the treatment landscape. See the main CNS lymphoma page for current regimens.
Consolidation and/or maintenance after upfront therapy
Observation
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Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Thiel et al. 2010 (G-PCNSL-SG-1) | 2000-2009 | Phase 3 (E-de-esc) | Whole-brain irradiation | Inconclusive whether non-inferior OS |
No further treatment.
Preceding treatment
- Before 2006: High-dose methotrexate x 6
- After 2006: High-dose methotrexate & ifosfamide x 6
References
- G-PCNSL-SG-1: Thiel E, Korfel A, Martus P, Kanz L, Griesinger F, Rauch M, Röth A, Hertenstein B, von Toll T, Hundsberger T, Mergenthaler HG, Leithäuser M, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Plasswilm L, Nägele T, Pietsch T, Bamberg M, Weller M. High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial. Lancet Oncol. 2010 Nov;11(11):1036-47. Epub 2010 Oct 20. link to original article contains verified protocol PubMed
- Update: Korfel A, Thiel E, Martus P, Möhle R, Griesinger F, Rauch M, Röth A, Hertenstein B, Fischer T, Hundsberger T, Mergenthaler HG, Junghanß C, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Roth P, Bamberg M, Pietsch T, Weller M. Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma. Neurology. 2015 Mar 24;84(12):1242-8. Epub 2015 Feb 25. link to original article PubMed