Difference between revisions of "Dactinomycin (Cosmegen)"

Revision as of 14:17, 1 November 2014

General information

Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.^[1]^[2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

12/10/1964: Initial FDA approval

Also known as

Synonyms
AC-DE	Actinomycin D	Actinomycin D Comp	Cosmegen	Dacmozen
Dactinomycin	K.U. Dactinomycin	Lyovac	Lyovac Cosmegen	Lyovac Cosmogen
Trav Dactinomycin

References

[insert-1] 1.0 ^1.1 Dactinomycin (Cosmegen) package insert

[2] Dactinomycin (Cosmegen) package insert (locally hosted backup)

[3] Dactinomycin (Cosmegen) patient drug information (Chemocare)

[4] Dactinomycin (Cosmegen) patient drug information (UpToDate)

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-Also known as Actinomycin or Actinomycin D.
 ==General information==
 Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050682s025lbl.pdf Dactinomycin (Cosmegen) package insert]</ref><ref>[[Media:Dactinomycin.pdf | Dactinomycin (Cosmegen) package insert (locally hosted backup)]]</ref>
@@ Line 15: / Line 13: @@
 *[http://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]</ref>
 *[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]</ref>
+==History of changes in FDA indication==
+* 12/10/1964: Initial FDA approval
+==Also known as==
+{| border="1" style="text-align:center;"
+!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
+|-
+|AC-DE
+|Actinomycin D
+|Actinomycin D Comp
+|Cosmegen
+|Dacmozen
+|-
+|Dactinomycin
+|K.U. Dactinomycin
+|Lyovac
+|Lyovac Cosmegen
+|Lyovac Cosmogen
+|-
+|Trav Dactinomycin
+|}
 ==References==
@@ Line 23: / Line 43: @@
 [[Category:Vesicant chemotherapy]]
 [[Category:DNA synthesis inhibitors]]
 [[Category:Bone cancer medications]]
 [[Category:Uterine cancer medications]]
+[[Category:Drugs FDA approved in 1964]]