Difference between revisions of "Filgrastim (Neupogen)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
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*[[Acute myeloid leukemia]] | *[[Acute myeloid leukemia]] | ||
Revision as of 14:49, 28 October 2014
General information
Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation.[1][2]
Route: SC, IV
Extravasation: no known issues
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Note that colony stimulating factors are used for their adjuvant effect e.g. removing leukemia stem cells from their protective niches; they are not thought to have inherent anti-cancer activity.
Patient drug information
- Filgrastim (Neupogen) package insert[1]
- Filgrastim (Neupogen) patient drug information (Chemocare)[3]
- Filgrastim (Neupogen) patient drug information (UpToDate)[4]
Also known as
BAO LI JIN, Biocilin, Biofigran, Biofilgran, Euprotin, Filatil, Filgen, Filgrastim, Filgrastima, GCSF, G-CSF, Gran, Gran Kirin, Granocyt, Granocyte, Granocyte 13, Granocyte 34, Gran Sankyo, Granulocyte Colony Stimulating Factor, Granulokine, Grasalva, Grasin, Grastim, Lenograstim, Leubene, Leucin, Leucocim, Leucokain, Leucostim, Leukokine, Leumostin, Lioplim, LI Sheng SU, Myelostim, Neukine, Neupogen, Neupogen Amgen 48, Neupogen Novum, Neupogen Singleject, Neutrogin, Nevkine, Nivestim, RUI BAI, TE ER JIN, Topneuter, XIN LI Sheng