Difference between revisions of "Mitotane (Lysodren)"
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==Patient drug information== | ==Patient drug information== | ||
*[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]</ref> | ||
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| + | ==History of changes in FDA indication== | ||
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| + | ==History of changes in EMA indication== | ||
| + | *4/28/2004: Indicated for symptomatic treatment of advanced (unresectable, metastatic or relapsed) [[Adrenocortical carcinoma|adrenal cortical carcinoma]]. The effect of Lysodren on non-functional adrenal cortical carcinoma is not established. | ||
==Also known as== | ==Also known as== | ||
Revision as of 00:35, 11 May 2021
General information
Class/mechanism: Adrenal cytotoxic agent, suppresses adrenal cortex and the extra-adrenal metabolism of cortisol.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
History of changes in FDA indication
History of changes in EMA indication
- 4/28/2004: Indicated for symptomatic treatment of advanced (unresectable, metastatic or relapsed) adrenal cortical carcinoma. The effect of Lysodren on non-functional adrenal cortical carcinoma is not established.
Also known as
- Generic name: o,p′-DDD
- Brand name: Lysodren