Difference between revisions of "Ifosfamide (Ifex)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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==Patient drug information== | ==Patient drug information== | ||
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==References== | ==References== | ||
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| + | [[Category:Nitrogen mustards]] | ||
| + | [[Category:Aggressive Non-Hodgkin lymphoma medications]] | ||
| + | [[Category:Bone cancer medications]] | ||
| + | [[Category:Central nervous system (CNS) cancer medications]] | ||
| + | [[Category:Cervical cancer medications]] | ||
| + | [[Category:HIV-associated lymphoma medications]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Penile cancer medications]] | ||
| + | [[Category:Sarcoma medications]] | ||
| + | [[Category:Small cell lung cancer medications]] | ||
| + | [[Category:T-cell lymphoma medications]] | ||
| + | [[Category:Testicular cancer medications]] | ||
| + | [[Category:Thymoma medications]] | ||
| + | [[Category:Uterine cancer medications]] | ||
Revision as of 19:40, 17 May 2014
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant
Note: A protective agent such as mesna should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
Also known as
Alquimid, Duvaxan, Fentul, Fosfidex, Haloxan, Holoxan, Holoxane, Ifex, IFO Cell, Ifocris, Ifolem, Ifomida, Ifomide, Ifos, Ifosfamida Delta Farma, Ifosfamida Filaxis, Ifosfamida Microsules, Ifosfamida Servycal, Ifoxan, IFX, Ipamide, Isophosphamide, Isoxan, Macdafen, Mitoxana, Mitoxana Lyophilisate, PI FU Ping, Trav Ifosfamide, Tronoxal, Vero Ifosfamide
References
- Nitrogen mustards
- Aggressive Non-Hodgkin lymphoma medications
- Bone cancer medications
- Central nervous system (CNS) cancer medications
- Cervical cancer medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Penile cancer medications
- Sarcoma medications
- Small cell lung cancer medications
- T-cell lymphoma medications
- Testicular cancer medications
- Thymoma medications
- Uterine cancer medications