Difference between revisions of "Abiraterone (Zytiga)"
m (→References) |
Warner-admin (talk | contribs) m |
||
Line 23: | Line 23: | ||
*'''Code name:''' CB7630 | *'''Code name:''' CB7630 | ||
*'''Generic name:''' abiraterone acetate | *'''Generic name:''' abiraterone acetate | ||
− | *'''Brand name:''' Zytiga | + | *'''Brand name:''' Yonsa, Zytiga |
==References== | ==References== | ||
Line 31: | Line 31: | ||
[[Category:Oral medications]] | [[Category:Oral medications]] | ||
− | |||
[[Category:Antiandrogens]] | [[Category:Antiandrogens]] | ||
[[Category:Steroid synthesis inhibitors]] | [[Category:Steroid synthesis inhibitors]] |
Revision as of 22:28, 28 February 2020
General information
Class/mechanism: Antiandrogen, androgen biosynthesis inhibitor, CYP17 inhibitor. Inhibits the 17 α-hydroxylase/C17,20-lyase (CYP17) enzyme that is required for androgen biosynthesis, leading to a decrease in androgen production in testicular, adrenal, and prostate tumor tissues.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Abiraterone (Zytiga) package insert[1]
- Abiraterone (Zytiga) patient drug information (Chemocare)[4]
- Janssen CarePath patient support resources[5]
- Abiraterone (Zytiga) patient drug information (UpToDate)[6]
History of changes in FDA indication
- 4/28/2011: FDA approved "to treat patients with late-stage (metastatic) castration-resistant prostate cancer who have received prior docetaxel (chemotherapy)."
- 12/10/2012: FDA approved "to treat men with late-stage (metastatic) castration-resistant prostate cancer prior to receiving chemotherapy."
- 2/7/2018: FDA approved "in combination with prednisone for metastatic high-risk castration-sensitive prostate cancer (CSPC)."
Also known as
- Code name: CB7630
- Generic name: abiraterone acetate
- Brand name: Yonsa, Zytiga
References
- ↑ 1.0 1.1 1.2 Abiraterone (Zytiga) package insert
- ↑ Abiraterone (Zytiga) package insert (locally hosted backup)
- ↑ Zytiga manufacturer's website
- ↑ Abiraterone (Zytiga) patient drug information (Chemocare)
- ↑ Janssen CarePath patient support resources
- ↑ Abiraterone (Zytiga) patient drug information (UpToDate)