Difference between revisions of "Vandetanib (Caprelsa)"
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==General information== | ==General information== | ||
Class/mechanism: Tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor), VEGF (vascular endothelial cell growth factor), RET (rearranged during transfection), BRK (breast tumor kinase/protein tyrosine kinase 6), TIE2, EPH, Src. Inhibits angiogenesis, endothelial cell migration, and tumor growth.<ref name="insert">[http://www1.astrazeneca-us.com/pi/vandetanib.pdf Vandetanib (Caprelsa) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/vandetanib.pdf Vandetanib (Caprelsa) package insert (locally hosted backup)]</ref><ref>[http://www.caprelsa.com Caprelsa manufacturer's website]</ref> | Class/mechanism: Tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor), VEGF (vascular endothelial cell growth factor), RET (rearranged during transfection), BRK (breast tumor kinase/protein tyrosine kinase 6), TIE2, EPH, Src. Inhibits angiogenesis, endothelial cell migration, and tumor growth.<ref name="insert">[http://www1.astrazeneca-us.com/pi/vandetanib.pdf Vandetanib (Caprelsa) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/vandetanib.pdf Vandetanib (Caprelsa) package insert (locally hosted backup)]</ref><ref>[http://www.caprelsa.com Caprelsa manufacturer's website]</ref> | ||
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*[http://www1.astrazeneca-us.com/pi/vandetanib.pdf#page=6 Vandetanib (Caprelsa) package insert PDF pages 6-8]<ref>[http://www1.astrazeneca-us.com/pi/vandetanib.pdf#page=6 Vandetanib (Caprelsa) package insert PDF pages 6-8]</ref> | *[http://www1.astrazeneca-us.com/pi/vandetanib.pdf#page=6 Vandetanib (Caprelsa) package insert PDF pages 6-8]<ref>[http://www1.astrazeneca-us.com/pi/vandetanib.pdf#page=6 Vandetanib (Caprelsa) package insert PDF pages 6-8]</ref> | ||
*[http://www.uptodate.com/contents/vandetanib-patient-drug-information Vandetanib (Caprelsa) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vandetanib-patient-drug-information Vandetanib (Caprelsa) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/vandetanib-patient-drug-information Vandetanib (Caprelsa) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vandetanib-patient-drug-information Vandetanib (Caprelsa) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | Zactima, ZD6474. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
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| + | [[Category:Kinase inhibitors]] | ||
| + | [[Category:EGFR inhibitors]] | ||
| + | [[Category:RET inhibitors]] | ||
| + | [[Category:VEGF inhibitors]] | ||
Revision as of 03:17, 10 January 2014
General information
Class/mechanism: Tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor), VEGF (vascular endothelial cell growth factor), RET (rearranged during transfection), BRK (breast tumor kinase/protein tyrosine kinase 6), TIE2, EPH, Src. Inhibits angiogenesis, endothelial cell migration, and tumor growth.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Vandetanib (Caprelsa) package insert PDF pages 6-8[5]
- Vandetanib (Caprelsa) patient drug information (UpToDate)[6]
Also known as
Zactima, ZD6474.
References
- ↑ 1.0 1.1 Vandetanib (Caprelsa) package insert
- ↑ Vandetanib (Caprelsa) package insert (locally hosted backup)
- ↑ Caprelsa manufacturer's website
- ↑ Caprelsa Risk Evaluation and Mitigation Strategy (REMS) Program
- ↑ Vandetanib (Caprelsa) package insert PDF pages 6-8
- ↑ Vandetanib (Caprelsa) patient drug information (UpToDate)