Difference between revisions of "Temozolomide (Temodar)"
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*[[Pancreatic NET]] | *[[Pancreatic NET]] | ||
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Revision as of 19:55, 1 March 2019
General information
Class/mechanism: Alkylator. Temozolomide is converted in vivo to the reactive compound 5-(3-methyltriazen-
1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.[1][2][3]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Anaplastic glioma
- CNS lymphoma
- Ewing sarcoma
- Glioblastoma
- Low-grade glioma
- Melanoma
- Myelodysplastic syndrome
- Neuroblastoma
- Neuroendocrine tumor
- Pancreatic NET
- Soft tissue sarcoma
- Small cell lung cancer
Patient drug information
- Temozolomide (Temodar) patient drug information from manufacturer[4]
- Temozolomide (Temodar) patient drug information (Chemocare)[5]
- Temozolomide (Temodar) patient drug information (UpToDate)[6]
History of changes in FDA indication
- 8/11/1999: Initial FDA approval
Also known as
- Generic name: TMZ
- Brand names: Gliotem, Temcad, Temizole, Temodal, Temodar, Temonat, Temoside, Temoz, Temzol
References
- ↑ 1.0 1.1 Temozolomide (Temodar) package insert
- ↑ Temozolomide (Temodar) package insert (locally hosted backup)
- ↑ Temodar manufacturer's website
- ↑ Temozolomide (Temodar) patient drug information from manufacturer
- ↑ Temozolomide (Temodar) patient drug information (Chemocare)
- ↑ Temozolomide (Temodar) patient drug information (UpToDate)
- Drugs
- Intravenous medications
- Oral medications
- Triazenes
- Alkylating agents
- Acute myeloid leukemia medications
- Anaplastic glioma medications
- CNS lymphoma medications
- Ewing sarcoma medications
- Glioblastoma medications
- Low-grade glioma medications
- Melanoma medications
- Myelodysplastic syndrome medications
- Neuroblastoma medications
- Neuroendocrine tumor medications
- Pancreatic NET medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- FDA approved in 1999