Difference between revisions of "Periampullary adenocarcinoma"

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| style="background-color:#F0F0F0; width:15%" |[[File:Ivy_Abraham.JPG|frameless|upright=0.3|center]]
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| style="width:35%" |<big>[[User:Ivyabraham|Ivy Abraham, MD]]<br>University of Illinois at Chicago<br>Chicago, IL</big>
 
| style="background-color:#F0F0F0; width:15%" |[[File:nkv.jpg|frameless|upright=0.3|center]]
 
| style="background-color:#F0F0F0; width:15%" |[[File:nkv.jpg|frameless|upright=0.3|center]]
| style="width:35%" |<big>[[User:Neetavenepalli|Neeta K. Venepalli, MD, MBA]]<br>Chicago, IL</big>
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| style="width:35%" |<big>[[User:Neetavenepalli|Neeta K. Venepalli, MD, MBA]]<br>University of Illinois at Chicago<br>Chicago, IL</big>
| style="background-color:#F0F0F0; width:15%" |[[File:Ivy_Abraham.JPG|frameless|upright=0.3|center]]
 
| style="width:35%" |<big>[[User:Ivyabraham|Ivy Abraham, MD]]<br>Chicago, IL</big>
 
 
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Revision as of 01:53, 31 January 2019

Page editor Section editor
Ivy Abraham.JPG
Ivy Abraham, MD
University of Illinois at Chicago
Chicago, IL
Nkv.jpg
Neeta K. Venepalli, MD, MBA
University of Illinois at Chicago
Chicago, IL
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Liver cancer or hepatobiliary cancer comprises cancers that arise within the liver and its hepatocytes (hepatocellular carcinoma) and the biliary tract cancers, which include bile duct cancer/cholangiocarcinoma and gallbladder cancer.

Guidelines

ESMO

NCCN

Adjuvant therapy

Observation

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Regimen

Study Evidence Comparator Efficacy
Takada et al. 2002 Phase III (C) 5-FU & Mitomycin Seems not superior
Neoptolemos et al. 2012 (ESPAC-3) Phase III (C) 1. 5-FU & Leucovorin
2. Gemcitabine
Seems not superior

No adjuvant therapy.

Preceding treatment

References

  1. Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H, Nagakawa T, Nakayama T; Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract. Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer. 2002 Oct 15;95(8):1685-95. link to original article PubMed
  2. ESPAC-3: Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer. Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA. 2012 Jul 11;308(2):147-56. Erratum in: JAMA. 2012 Nov 14;308(18):1861. link to original article PubMed