Difference between revisions of "Isotretinoin (Accutane)"
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| − | + | ==Mechanism of action== | |
| + | From the [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/isotretinoin NCI Drug Dictionary]: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. | ||
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| + | ==Diseases for which it is used== | ||
| + | *[[Neuroblastoma]] | ||
| + | *[[Squamous cell carcinoma (SCC)]] | ||
| + | |||
==Also known as== | ==Also known as== | ||
| − | *'''Brand | + | *'''Code name:''' Ro 4-3780 |
| + | *'''Generic names:''' 13-cis-retinoic acid, 13-cis-vitamin A acid, cis-retinoic acid, isotretinoinum, neovitamin A | ||
| + | *'''Brand names:''' Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 19:53, 23 July 2018
Mechanism of action
From the NCI Drug Dictionary: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Diseases for which it is used
Also known as
- Code name: Ro 4-3780
- Generic names: 13-cis-retinoic acid, 13-cis-vitamin A acid, cis-retinoic acid, isotretinoinum, neovitamin A
- Brand names: Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret