Difference between revisions of "Carmustine (BCNU)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *[[ | + | *[[Anaplastic glioma]] |
| + | *[[CNS lymphoma]] | ||
| + | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Follicular lymphoma]] | ||
| + | *[[Glioblastoma]] | ||
| + | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
| + | *[[Mantle cell lymphoma]] | ||
*[[Melanoma]] | *[[Melanoma]] | ||
| − | *[[ | + | |
| + | ==Diseases for which is was used== | ||
| + | *[[Multiple myeloma - obsolete|Multiple myeloma]] | ||
==Patient drug information== | ==Patient drug information== | ||
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==Also known as== | ==Also known as== | ||
| − | + | *'''Generic names:''' BCNU, bischloroethylnitrosourea, carmustin | |
| − | + | *'''Brand names:''' Becenun, BiCNU, Carmubris, Gliadel, Gliadel Wafer, Leucerom, Nitrourean, Nitrumon | |
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==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
| − | |||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
| Line 51: | Line 42: | ||
[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
| − | [[Category: | + | [[Category:Anaplastic glioma medications]] |
| + | [[Category:CNS lymphoma medications]] | ||
| + | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Follicular lymphoma medications]] | ||
| + | [[Category:Glioblastoma medications]] | ||
| + | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Mantle cell lymphoma medications]] | ||
[[Category:Melanoma medications]] | [[Category:Melanoma medications]] | ||
[[Category:Transplant medications]] | [[Category:Transplant medications]] | ||
[[Category:Drugs FDA approved in 1977]] | [[Category:Drugs FDA approved in 1977]] | ||
Revision as of 02:12, 21 January 2018
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.[1][2]
Route: IV
Extravasation: vesicant/irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Anaplastic glioma
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Glioblastoma
- HIV-associated lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- Melanoma
Diseases for which is was used
Patient drug information
- Carmustine (BiCNU) patient drug information (Chemocare)[3]
- Carmustine (BiCNU) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/7/1977: Initial FDA approval
Also known as
- Generic names: BCNU, bischloroethylnitrosourea, carmustin
- Brand names: Becenun, BiCNU, Carmubris, Gliadel, Gliadel Wafer, Leucerom, Nitrourean, Nitrumon
References
Categories:
- Drug index
- Intravenous medications
- Irritant chemotherapy
- Vesicant chemotherapy
- Nitrosoureas
- Alkylating agents
- Anaplastic glioma medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Follicular lymphoma medications
- Glioblastoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- Melanoma medications
- Transplant medications
- Drugs FDA approved in 1977