Difference between revisions of "Decitabine (Dacogen)"
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| + | Also known as 5-aza-2'-deoxycytidine. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: Pyrimidine/cytosine analog, DNA hypomethylating agent. Incorporates into DNA and inhibits DNA methyltransferase, causing DNA hypomethylation, which results in cellular differentiation or apoptosis.<ref name="insert">[http:// | + | Class/mechanism: Pyrimidine/cytosine analog, DNA hypomethylating agent. Incorporates into DNA and inhibits DNA methyltransferase, causing DNA hypomethylation, which results in cellular differentiation or apoptosis.<ref name="insert">[http://us.eisai.com/pdf_files/Dacogen_PI.pdf Decitabine (Dacogen) package insert]</ref><ref>[[Media:Decitabine.pdf | Decitabine (Dacogen) package insert (locally hosted backup)]]</ref><ref>[http://dacogen.com Dacogen manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute myeloid leukemia]] | ||
| + | *[[Myelodysplastic syndrome]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http:// | + | *[http://chemocare.com/chemotherapy/drug-info/decitabine.aspx Decitabine (Dacogen) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/decitabine.aspx Decitabine (Dacogen) patient drug information (Chemocare)]</ref> |
| + | *Brief patient counseling information can be found on [http://us.eisai.com/pdf_files/Dacogen_PI.pdf#page=8 pages 8-9 of the Decitabine (Dacogen) package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/decitabine-patient-drug-information Decitabine (Dacogen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/decitabine-patient-drug-information Decitabine (Dacogen) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/decitabine-patient-drug-information Decitabine (Dacogen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/decitabine-patient-drug-information Decitabine (Dacogen) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Nucleic acid analogs]] | ||
| + | [[Category:Acute myeloid leukemia medications]] | ||
| + | [[Category:Myelodysplastic syndrome medications]] | ||
Revision as of 18:40, 14 October 2012
Also known as 5-aza-2'-deoxycytidine.
General information
Class/mechanism: Pyrimidine/cytosine analog, DNA hypomethylating agent. Incorporates into DNA and inhibits DNA methyltransferase, causing DNA hypomethylation, which results in cellular differentiation or apoptosis.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Decitabine (Dacogen) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on pages 8-9 of the Decitabine (Dacogen) package insert[1]
- Decitabine (Dacogen) patient drug information (UpToDate)[5]