Difference between revisions of "Antithrombin III (human and recombinant)"
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==General information== | ==General information== | ||
Class/mechanism: Inhibitor of thrombin, which converts fibrinogen to fibrin in the coagulation cascade and subsequent development of thrombus. Clinical applications include management of patients with hereditary antithrombin III (AT-III) deficiency. Please choose from the products below to find specific drug/manufacturer information: | Class/mechanism: Inhibitor of thrombin, which converts fibrinogen to fibrin in the coagulation cascade and subsequent development of thrombus. Clinical applications include management of patients with hereditary antithrombin III (AT-III) deficiency. Please choose from the products below to find specific drug/manufacturer information: | ||
| − | *Antithrombin III, human (Thrombate III)<ref>[http://www.thrombate.com/ Thrombate III manufacturer's website]</ref><ref name="insert">[http://www.talecris-pi.info/inserts/thrombate.pdf Antithrombin III, human (Thrombate III) package insert]</ref><ref>[ | + | *Antithrombin III, human (Thrombate III)<ref>[http://www.thrombate.com/ Thrombate III manufacturer's website]</ref><ref name="insert">[http://www.talecris-pi.info/inserts/thrombate.pdf Antithrombin III, human (Thrombate III) package insert]</ref><ref>[[Media:Antithrombiniii.pdf | Antithrombin III, human (Thrombate III) package insert (locally hosted backup)]]</ref> |
| − | *Antithrombin III, recombinant (ATryn)<ref>[http://atryn.com/ ATryn manufacturer's website]</ref><ref>[http://atryn.com/pdf/ATryn_PI_0409.pdf Antithrombin III, recombinant (ATryn) package insert]</ref><ref>[ | + | *Antithrombin III, recombinant (ATryn)<ref>[http://atryn.com/ ATryn manufacturer's website]</ref><ref name="atryn">[http://atryn.com/pdf/ATryn_PI_0409.pdf Antithrombin III, recombinant (ATryn) package insert]</ref><ref>[[Media:Antithrombiniiiatryn.pdf | Antithrombin III, recombinant (ATryn) package insert (locally hosted backup)]]</ref> |
Route: IV | Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref><ref name="atryn"></ref> |
==Patient drug information== | ==Patient drug information== | ||
*[http://www.uptodate.com/contents/antithrombin-iii-patient-drug-information Antithrombin III (human and recombinant) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/antithrombin-iii-patient-drug-information Antithrombin III (human and recombinant) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/antithrombin-iii-patient-drug-information Antithrombin III (human and recombinant) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/antithrombin-iii-patient-drug-information Antithrombin III (human and recombinant) patient drug information (UpToDate)]</ref> | ||
| + | *Brief patient counseling information can be found on [http://atryn.com/pdf/ATryn_PI_0409.pdf#page=15 page 15 of the ATryn package insert]<ref name="atryn"></ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 04:41, 7 October 2012
May be known as antithrombin (human), antithrombin (recombinant), ATryn, or Thrombate III.
General information
Class/mechanism: Inhibitor of thrombin, which converts fibrinogen to fibrin in the coagulation cascade and subsequent development of thrombus. Clinical applications include management of patients with hereditary antithrombin III (AT-III) deficiency. Please choose from the products below to find specific drug/manufacturer information:
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[2][5]
Patient drug information
- Antithrombin III (human and recombinant) patient drug information (UpToDate)[7]
- Brief patient counseling information can be found on page 15 of the ATryn package insert[5]
References
- ↑ Thrombate III manufacturer's website
- ↑ 2.0 2.1 Antithrombin III, human (Thrombate III) package insert
- ↑ Antithrombin III, human (Thrombate III) package insert (locally hosted backup)
- ↑ ATryn manufacturer's website
- ↑ 5.0 5.1 5.2 Antithrombin III, recombinant (ATryn) package insert
- ↑ Antithrombin III, recombinant (ATryn) package insert (locally hosted backup)
- ↑ Antithrombin III (human and recombinant) patient drug information (UpToDate)