Difference between revisions of "Ondansetron (Zofran)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.<ref name=insert>[ | + | Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.<ref name=insert>[http://www.pharma.us.novartis.com/product/pi/pdf/zofran.pdf Ondansetron (Zofran) package insert]</ref><ref>[[Media:Ondansetron.pdf | Ondansetron (Zofran) package insert (locally hosted backup)]]</ref> |
<br>Route: PO, IV | <br>Route: PO, IV | ||
<br>Extravasation: no information available | <br>Extravasation: no information available | ||
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==Patient drug information== | ==Patient drug information== | ||
| + | *Patient counseling information can be found in the [http://www.pharma.us.novartis.com/product/pi/pdf/zofran.pdf Ondansetron (Zofran) package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/ondansetron-patient-drug-information Ondansetron (Zofran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ondansetron-patient-drug-information Ondansetron (Zofran) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/ondansetron-patient-drug-information Ondansetron (Zofran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ondansetron-patient-drug-information Ondansetron (Zofran) patient drug information (UpToDate)]</ref> | ||
Revision as of 05:52, 14 April 2017
General information
Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.[1][2]
Route: PO, IV
Extravasation: no information available
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Patient counseling information can be found in the Ondansetron (Zofran) package insert[1]
- Ondansetron (Zofran) patient drug information (UpToDate)[3]
History of changes in FDA indication
- 1/4/1991: Initial FDA approval
Also known as
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Alencar | Amilene | ANG DAN Tong | Ansentron | Anset | AN SI XIN | AO YI MAI | Atossa |
| Bryterol | Cedantron | Ceramos | Cloridrato DE Ondansetrona | Danofran | Dantenk | Emeran | Emeset |
| Emetra | Emetron | Emigo | Emistat | Emivox | EN NUO Ping | Espasevit | Finaber |
| Finoxi | Frazon | FU MI Ting | Glendan | Helmine | Injectrax | Insetron | Invomit |
| Izofran | Latran | Modifical | Narfoz | Nausedron | Nautah | Neomit | Nuset |
| O.N.D. | Odanex | Odanse | Ometic | Omstron | Onaset | Oncotor | Onda |
| Ondace | Ondan | Ondanles | Ondansetron | Ondansetron-Z | Ondansetron Alpharma | Ondansetron CF | Ondansetron Denver Farma |
| Ondansetron Epicaris | Ondansetron Fabra | Ondansetron Filaxis | Ondansetron Gobbi | Ondansetron Hydrochloride | Ondansetron Lazar | Ondansetron Martian | Ondansetron Nycomed |
| Ondansetron ODT | Ondansetron Ratiopharm | Ondant | Ondaren | Ondasetron | Ondatie | Ondavell | Ondem |
| Ondemet | Onfran | Onilat | Onsat | Onseran | Onset | Onsetron | Onsett |
| Onsia | Ontrax | Onzod | Osetron | Ostasyn | Otobrol | Periset | Quimiofran |
| Seton | Setronax | Setronon | SHI TAI | SN-307 | Sopran | Trorix | Vero Ondansetron |
| Vomceran | Vomiban | Vomigo | Vomikind | Vomiset | Vomitron | Vomiz | Vonau |
| WEI ZE | Yatrox | Zantron | Zapron | Zemitron | Zofer | Zofran | Zofran ODT |
| Zofran Sankyo | Zofron | Zoltem | Zonax | Zondan | Zophren | Zudan | |