Difference between revisions of "Romidepsin (Istodax)"
m (moved Romidepsin (Isodax) to Romidepsin (Istodax): name) |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.istodax.com/pdfs/ISTODAX_PackageInsert.pdf Romidepsin (Isodax) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/romidepsin.pdf Romidepsin (Isodax) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Histone deacetylase (HDAC) inhibitor. HDACs normally catalyze removal of acetyl groups from acetylated lysine residues in histones and non-histone proteins, which helps to regulate gene expression. Inhibiting HDACs and the consequent accumulation of acetylated histones results in cell cycle arrest and apoptosis of cancer cells.<ref name="insert">[http://www.istodax.com/pdfs/ISTODAX_PackageInsert.pdf Romidepsin (Isodax) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/romidepsin.pdf Romidepsin (Isodax) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: no information |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://www.istodax.com/pdfs/ISTODAX_PackageInsert.pdf#page=8 Romidepsin (Isodax) package insert PDF pages 8-9]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/romidepsin-patient-drug-information Romidepsin (Isodax) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/romidepsin-patient-drug-information Romidepsin (Isodax) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/romidepsin-patient-drug-information Romidepsin (Isodax) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/romidepsin-patient-drug-information Romidepsin (Isodax) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 20:18, 24 February 2012
General information
Class/mechanism: Histone deacetylase (HDAC) inhibitor. HDACs normally catalyze removal of acetyl groups from acetylated lysine residues in histones and non-histone proteins, which helps to regulate gene expression. Inhibiting HDACs and the consequent accumulation of acetylated histones results in cell cycle arrest and apoptosis of cancer cells.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Romidepsin (Isodax) package insert PDF pages 8-9[1]
- Romidepsin (Isodax) patient drug information (UpToDate)[3]