Difference between revisions of "Tamoxifen (Nolvadex)"
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| + | Also known as Istubal, Soltamox, or Valodex. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/17970s053lbl.pdf Tamoxifen (Nolvadex) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/tamoxifen.pdf Tamoxifen (Nolvadex) package insert (locally hosted backup)]</ref> | + | Class/mechanism: SERM (selective estrogen receptor modulator), with estrogen agonist/antagonist properties depending on tissue type. Tamoxifen has estrogen antagonist properties in breast tissue. It has estrogen agonist properties in bone, helping to decrease bone resorption, but in contrast to [[Raloxifene (Evista)]], it also has agonist properties in uterine tissue.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/17970s053lbl.pdf Tamoxifen (Nolvadex) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/tamoxifen.pdf Tamoxifen (Nolvadex) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: PO |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/17970s053lbl.pdf#page=32 Tamoxifen (Nolvadex) package insert PDF pages 32-37]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/tamoxifen.asp Tamoxifen (Nolvadex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/tamoxifen.asp Tamoxifen (Nolvadex) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/tamoxifen.asp Tamoxifen (Nolvadex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/tamoxifen.asp Tamoxifen (Nolvadex) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/tamoxifen-patient-drug-information Tamoxifen (Nolvadex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/tamoxifen-patient-drug-information Tamoxifen (Nolvadex) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/tamoxifen-patient-drug-information Tamoxifen (Nolvadex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/tamoxifen-patient-drug-information Tamoxifen (Nolvadex) patient drug information (UpToDate)]</ref> | ||
Revision as of 23:13, 24 February 2012
Also known as Istubal, Soltamox, or Valodex.
General information
Class/mechanism: SERM (selective estrogen receptor modulator), with estrogen agonist/antagonist properties depending on tissue type. Tamoxifen has estrogen antagonist properties in breast tissue. It has estrogen agonist properties in bone, helping to decrease bone resorption, but in contrast to Raloxifene (Evista), it also has agonist properties in uterine tissue.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Tamoxifen (Nolvadex) package insert PDF pages 32-37[1]
- Tamoxifen (Nolvadex) patient drug information (Chemocare)[3]
- Tamoxifen (Nolvadex) patient drug information (UpToDate)[4]