Difference between revisions of "Meningioma"

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==[https://www.nccn.org/ NCCN]==
 
==[https://www.nccn.org/ NCCN]==
 
*''NCCN does not have guidelines at this granular level; please see [https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf NCCN Guidelines - Central Nervous System Cancers].''
 
*''NCCN does not have guidelines at this granular level; please see [https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf NCCN Guidelines - Central Nervous System Cancers].''
 
=Unresectable, all lines of therapy=
 
==Placebo==
 
<div class="toccolours" style="background-color:#eeeeee">
 
===Regimen===
 
{| class="wikitable sortable" style="width: 100%; text-align:center;"
 
!style="width: 20%"|Study
 
!style="width: 20%"|Dates of enrollment
 
!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
!style="width: 20%"|Comparator
 
!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
 
|-
 
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669593/ Ji et al. 2015 (SWOG S9005)]
 
|1992-1998
 
|style="background-color:#1a9851"|Phase 3 (C)
 
|[[#Mifepristone_999|Mifepristone]]
 
| style="background-color:#ffffbf" |Did not meet primary endpoint of FFS
 
|-
 
|}
 
''No active antineoplastic treatment.''
 
</div>
 
===References===
 
# '''SWOG S9005:''' Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2. [https://doi.org/10.1200/JCO.2015.61.6490 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669593/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/26527781/ PubMed] [https://clinicaltrials.gov/study/NCT03015701 NCT03015701]
 
  
 
[[Category:Meningioma regimens]]
 
[[Category:Meningioma regimens]]
 
[[Category:Disease-specific pages]]
 
[[Category:Disease-specific pages]]
 
[[Category:CNS cancers]]
 
[[Category:CNS cancers]]

Revision as of 12:12, 5 November 2023

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Seema Nagpal, MD
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Given the rapid change in evidence in many areas of hematology/oncology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

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