Dinutuximab (Unituxin)

Mechanism of action

From the NCI drug dictionary: A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.
Route: IV

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Diseases for which it is used

• Neuroblastoma

History of changes in FDA indication

• 3/10/2015: Initial FDA approval "in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy."

Also known as

Ch14.18, MOAB Ch14.18, monoclonal antibody Ch14.18