Difference between revisions of "Busulfan (Myleran)"
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Warner-admin (talk | contribs) m (Text replacement - "[[Chronic myelogenous leukemia" to "[[Chronic myeloid leukemia") |
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*[[Acute promyelocytic leukemia]] | *[[Acute promyelocytic leukemia]] | ||
*[[Chronic lymphocytic leukemia]] | *[[Chronic lymphocytic leukemia]] | ||
| − | *[[Chronic | + | *[[Chronic myeloid leukemia]] |
*[[Ewing sarcoma]] | *[[Ewing sarcoma]] | ||
*Non-Hodgkin lymphoma | *Non-Hodgkin lymphoma | ||
| Line 33: | Line 33: | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
* 6/26/1954: Initial FDA approval | * 6/26/1954: Initial FDA approval | ||
| − | *1/23/2003 (oldest label available at Drugs@FDA): indicated for the palliative treatment of [[Chronic | + | *1/23/2003 (oldest label available at Drugs@FDA): indicated for the palliative treatment of [[Chronic myeloid leukemia|chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia]]. ''(No supporting studies are cited)'' |
==Also known as== | ==Also known as== | ||
Revision as of 00:28, 6 September 2022
General information
Class/mechanism: Bifunctional alkylating agent which produces guanine-adenine intrastrand crosslinks, inducing apoptosis.[1][2][3][4]
Route: IV, PO
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Chronic lymphocytic leukemia
- Chronic myeloid leukemia
- Ewing sarcoma
- Non-Hodgkin lymphoma
- Myelodysplastic syndrome
- Neuroblastoma
Diseases for which it was used
Patient drug information
- Busulfan (Myleran) package insert[1]
- Busulfan (Myleran) patient drug information (Chemocare)[5]
- Busulfan (Myleran) patient drug information (UpToDate)[6]
History of changes in FDA indication
- 6/26/1954: Initial FDA approval
- 1/23/2003 (oldest label available at Drugs@FDA): indicated for the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia. (No supporting studies are cited)
Also known as
- Brand names: Busulfex, Myleran
References
- ↑ 1.0 1.1 1.2 Busulfan (Myleran) package insert
- ↑ Busulfan (Myleran) package insert (locally hosted backup)
- ↑ Busulfan (Busulfex) package insert
- ↑ Busulfan (Busulfex) package insert (locally hosted backup)
- ↑ Busulfan (Myleran) patient drug information (Chemocare)
- ↑ Busulfan (Myleran) patient drug information (UpToDate)
Categories:
- Drugs
- Oral medications
- Intravenous medications
- Alkylating agents
- Irritant
- Acute myeloid leukemia medications
- Acute promyelocytic leukemia medications
- Anaplastic large cell lymphoma medications
- Chronic lymphocytic leukemia medications
- Chronic myelogenous leukemia medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Ewing sarcoma medications
- Mantle cell lymphoma medications
- Myelodysplastic syndrome medications
- Neuroblastoma medications
- NK- and T-cell lymphoma medications
- Peripheral T-cell lymphoma medications
- Primary mediastinal B-cell lymphoma medications
- Multiple myeloma medications (historic)
- FDA approved in 1954