Difference between revisions of "Cladribine (Leustatin)"
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*[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
*[[Hairy cell leukemia]] | *[[Hairy cell leukemia]] | ||
+ | *[[Hypereosinophilic syndrome]] | ||
*[[Mantle cell lymphoma]] | *[[Mantle cell lymphoma]] | ||
*[[Marginal zone lymphoma]] | *[[Marginal zone lymphoma]] |
Revision as of 18:42, 6 September 2015
General information
Class/mechanism: Purine analog; mimics the nucleoside adenosine, inhibiting adenosine deaminase, which interferes with DNA synthesis and repair.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Hairy cell leukemia
- Hypereosinophilic syndrome
- Mantle cell lymphoma
- Marginal zone lymphoma
- Mast cell diseases
- Waldenström macroglobulinemia
Patient drug information
- Cladribine (Leustatin) patient drug information (Chemocare)[3]
- Cladribine (Leustatin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 2/26/1993: Initial FDA approval
Also known as
2-chlorodeoxyadenosine, 2-CdA, Litak, Movectro
References
Categories:
- Drug index
- Chemotherapy
- Intravenous chemotherapy
- Irritant chemotherapy
- Antimetabolites
- Purine analogues
- Acute myeloid leukemia medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Hairy cell leukemia medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Mast cell diseases
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 1993