Difference between revisions of "Autoimmune cytopenia"
Jump to navigation
Jump to search
m |
Warner-admin (talk | contribs) m (Text replacement - "|Phase II" to "|Phase 2") |
||
| Line 33: | Line 33: | ||
|- | |- | ||
|[https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2001.03039.x/full Willis et al. 2001] | |[https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2001.03039.x/full Willis et al. 2001] | ||
| − | |style="background-color:#91cf61"|Phase | + | |style="background-color:#91cf61"|Phase 2 |
|style="background-color:#b5b5b5"|ORR: 71% | |style="background-color:#b5b5b5"|ORR: 71% | ||
|- | |- | ||
| Line 60: | Line 60: | ||
|- | |- | ||
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705607/ Bride et al. 2015] | |[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705607/ Bride et al. 2015] | ||
| − | |style="background-color:#91cf61"|Phase | + | |style="background-color:#91cf61"|Phase 2 |
| style="background-color:#91cf60" |Durable CR observed in patients with ALPS | | style="background-color:#91cf60" |Durable CR observed in patients with ALPS | ||
|- | |- | ||
Revision as of 17:51, 12 February 2022
| Page editor | Section editor | ||
|---|---|---|---|
 |
Ronak H. Mistry, DO Vanderbilt University Nashville, TN  @rmistry91
|
 |
Benjamin Tillman, MD Vanderbilt University Nashville, TN |
2 regimens on this page
2 variants on this page
|
This is an umbrella category that includes Felty's syndrome (autoimmune neutropenia), autoimmune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), and Evan's syndrome (AIHA & ITP). Please see the respective page(s) for disease-specific therapies. This page includes regimens that were used more broadly.
Relapsed or refractory
Alemtuzumab monotherapy
| back to top |
Regimen
| Study | Evidence | Efficacy |
|---|---|---|
| Willis et al. 2001 | Phase 2 | ORR: 71% |
Immunosuppressive therapy
- Alemtuzumab (Campath) as follows:
- Test dose: 1 mg IV over 60 minutes once
- Days 1 to 10: 10 mg IV over 4 hours once per day
10-day course
References
- Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol. 2001 Sep;114(4):891-8. link to original article contains verified protocol PubMed
Sirolimus monotherapy
| back to top |
Regimen
| Study | Evidence | Efficacy |
|---|---|---|
| Bride et al. 2015 | Phase 2 | Durable CR observed in patients with ALPS |
Immunosuppressive therapy
- Sirolimus (Rapamune) 2 to 2.5 mg/m2/day PO
- See manuscript for recommended dose adjustments
6-month course, extended for those with a favorable response
References
- Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28. Epub 2015 Oct 26. link to original article link to PMC article contains protocol PubMed