Difference between revisions of "Non-small cell lung cancer, MET-mutated"
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|[https://doi.org/10.1200/JCO.2019.37.15_suppl.9004 Wolf et al. 2019 (GEOMETRY mono-1)] | |[https://doi.org/10.1200/JCO.2019.37.15_suppl.9004 Wolf et al. 2019 (GEOMETRY mono-1)] | ||
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| − | |style="background-color:#91cf61"|Phase II | + | |style="background-color:#91cf61"|Phase II (RT) |
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Revision as of 22:43, 9 May 2020
| Section editor | |
|---|---|
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Travis Osterman, DO, MS Vanderbilt University Nashville, TN  TravisOsterman |
Note: these are regimens tested in biomarker-specific populations, please see the main NSCLC page for other regimens.
3 regimens on this page
3 variants on this page
|
Metastatic disease
Capmatinib monotherapy
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Regimen
| FDA-recommended dose |
| Study | Years of enrollment | Evidence |
|---|---|---|
| Wolf et al. 2019 (GEOMETRY mono-1) | Phase II (RT) |
Biomarker Eligibility Criteria
- Biomarker: MET exon 14 skipping
Chemotherapy
- Capmatinib (Tabrecta) 400 mg PO twice per day with or without food
Continued indefinitely
References
- GEOMETRY mono-1: Juergen Wolf, Takashi Seto, Ji-Youn Han, Noemi Reguart, Edward B. Garon, Harry J.M. Groen, Daniel Shao-Weng Tan, Toyoaki Hida, Maja J. De Jonge, Sergey V. Orlov, Egbert F. Smit, Pierre Jean Souquet, Johan F. Vansteenkiste, Monica Giovannini, Sylvie Le Mouhaer, Anna Robeva, Maeve Waldron-Lynch, Rebecca Suk Heist. Capmatinib (INC280) in METΔex14-mutated advanced non-small cell lung cancer (NSCLC): Efficacy data from the phase II GEOMETRY mono-1 study. link to abstract contains verified protocol DOI