Difference between revisions of "Isotretinoin (Accutane)"
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*[[Neuroblastoma]] | *[[Neuroblastoma]] | ||
*[[Cutaneous squamous cell carcinoma]] | *[[Cutaneous squamous cell carcinoma]] | ||
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| + | == Patient Drug Information== | ||
| + | *[https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018662s059lbl.pdf Isotretinoin (Accutane) Package Insert]<ref>[https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018662s059lbl.pdf Isotretinoin (Accutane) Package Insert]</ref> | ||
==Also known as== | ==Also known as== | ||
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*'''Generic names:''' 13-cis-retinoic acid, 13-cis-vitamin A acid, 13-CRA, cis-retinoic acid, isotretinoinum, neovitamin A | *'''Generic names:''' 13-cis-retinoic acid, 13-cis-vitamin A acid, 13-CRA, cis-retinoic acid, isotretinoinum, neovitamin A | ||
*'''Brand names:''' Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret | *'''Brand names:''' Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret | ||
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| + | ==References== | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 11:27, 4 April 2021
Mechanism of action
From the NCI Drug Dictionary: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Diseases for which it is used
Patient Drug Information
Also known as
- Code name: Ro 4-3780
- Generic names: 13-cis-retinoic acid, 13-cis-vitamin A acid, 13-CRA, cis-retinoic acid, isotretinoinum, neovitamin A
- Brand names: Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret