Difference between revisions of "Temozolomide (Temodar)"

Revision as of 02:23, 18 May 2019

General information

Class/mechanism: Alkylator. Temozolomide is converted in vivo to the reactive compound 5-(3-methyltriazen- 1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.^[1]^[2]
Route: PO, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

8/11/1999: Initial FDA approval

Also known as

Generic name: TMZ
Brand names: Gliotem, Temcad, Temizole, Temodal, Temodar, Temonat, Temoside, Temoz, Temzol

References

[insert-1] 1.0 ^1.1 ^1.2 Temozolomide (Temodar) package insert

[2] Temozolomide (Temodar) package insert (locally hosted backup)

[3] Temozolomide (Temodar) patient drug information (Chemocare)

[4] Temozolomide (Temodar) patient drug information (UpToDate)

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
 ==General information==
 Class/mechanism: Alkylator.  Temozolomide is converted in vivo to the reactive compound 5-(3-methyltriazen-
--yl)-imidazole-4-carboxamide (MTIC).  MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.<ref name="insert">[http://www.spfiles.com/pitemodar.pdf Temozolomide (Temodar) package insert]</ref><ref>[[Media:Temozolomide.pdf | Temozolomide (Temodar) package insert (locally hosted backup)]]</ref><ref>[http://temodar.com Temodar manufacturer's website]</ref>
+-yl)-imidazole-4-carboxamide (MTIC).  MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.<ref name="insert">[https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf Temozolomide (Temodar) package insert]</ref><ref>[[Media:Temozolomide.pdf | Temozolomide (Temodar) package insert (locally hosted backup)]]</ref>
 <br>Route: PO, IV
 <br>Extravasation: no information
@@ Line 23: / Line 23: @@
 ==Patient drug information==
-*[http://www.spfiles.com/ppitemodar.pdf Temozolomide (Temodar) patient drug information from manufacturer]<ref>[http://www.spfiles.com/ppitemodar.pdf Temozolomide (Temodar) patient drug information from manufacturer]</ref>
+*[https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf Temozolomide (Temodar) package insert]<ref name="insert"></ref>
 *[http://chemocare.com/bio/temozolomide.asp Temozolomide (Temodar) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/temozolomide.asp Temozolomide (Temodar) patient drug information (Chemocare)]</ref>
 *[http://www.uptodate.com/contents/temozolomide-patient-drug-information Temozolomide (Temodar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/temozolomide-patient-drug-information Temozolomide (Temodar) patient drug information (UpToDate)]</ref>