Difference between revisions of "Cyclophosphamide (Cytoxan)"

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Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[[Media:Cyclophosphamide.pdf | Cyclophosphamide (Cytoxan) package insert (locally hosted backup)]]</ref>
 
Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[[Media:Cyclophosphamide.pdf | Cyclophosphamide (Cytoxan) package insert (locally hosted backup)]]</ref>
 
<br>Route: IV, PO
 
<br>Route: IV, PO
−
<br>Extravasation: no information, n/a
+
<br>Extravasation: [[irritant]], n/a
  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
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[[Category:Drug index]]
 
[[Category:Drug index]]
 
[[Category:Chemotherapy]]
 
[[Category:Chemotherapy]]
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[[Category:Irritant chemotherapy]]
 
[[Category:Alkylating agents]]
 
[[Category:Alkylating agents]]
 
[[Category:Acute lymphocytic leukemia medications]]
 
[[Category:Acute lymphocytic leukemia medications]]
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[[Category:Bladder cancer medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
 
[[Category:Breast cancer medications]]
 
[[Category:Breast cancer medications]]
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[[Category:Central nervous system (CNS) cancer medications]]
 
[[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]]
 
[[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]]
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[[Category:Follicular lymphoma medications]]
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[[Category:HIV-associated lymphoma medications]]
 
[[Category:Hodgkin lymphoma medications]]
 
[[Category:Hodgkin lymphoma medications]]
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[[Category:Hodgkin lymphoma, nodular lymphocyte-predominant medications]]
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[[Category:Light-chain (AL) amyloidosis medications]]
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[[Category:Mantle cell lymphoma medications]]
 
[[Category:Multiple myeloma medications]]
 
[[Category:Multiple myeloma medications]]
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[[Category:Neuroendocrine tumor medications]]
 
[[Category:Non-Hodgkin lymphoma medications]]
 
[[Category:Non-Hodgkin lymphoma medications]]
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[[Category:Prostate cancer medications]]
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[[Category:Small cell lung cancer medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Transplant medications]]
 
[[Category:Transplant medications]]

Revision as of 03:22, 16 August 2013

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: irritant, n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

Also known as

Alkyloxan, Biodoxan, Carloxan, Ciclofosfamida, Ciclofosfamida Filaxis, Ciclofosfamida Martian, Ciclokebir, Cyclam, Cycloblastin, Cycloblastine, Cyclo Cell, Cycloferon, Cyclomide, Cyclophar, Cyclophospham, Cyclophosphamid, cyclophosphamide monohydrate, Cyclophosphamid Farmos, Cyclophosphan, Cyclophosphan Lens, Cyclostin, Cycloxan, Cycram, Cydoxan, Cyklofosfamid, Cytophosphan, Cytoxan, Cytoxan Lyophilized, Endoxan, Endoxan-N, Endoxana, Endoxan Asta, Formitex, Genoxal, Genuxal, Hidrofosmin, Ledoxan, Ledoxina, Lyophilized Cytoxan, Neosar, Oncomide, Oncophos, Procytox, Revimmune, Sendoxan, Syklofosfamid, Trav Cyclophosphamide, Tymtran, Zycram

References

  1. ↑ 1.0 1.1 Cyclophosphamide (Cytoxan) package insert
  2. ↑ Cyclophosphamide (Cytoxan) package insert (locally hosted backup)
  3. ↑ Cyclophosphamide (Cytoxan) patient drug information (Chemocare)
  4. ↑ Cyclophosphamide (Cytoxan) patient drug information (UpToDate)
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