Difference between revisions of "Methotrexate (MTX)"
Jump to navigation
Jump to search
Warner-admin (talk | contribs) m (Text replacement - "Category:Central nervous system (CNS) lymphoma medications" to "Category:CNS lymphoma medications") |
m |
||
| Line 19: | Line 19: | ||
*[[Diffuse large B-cell lymphoma]] | *[[Diffuse large B-cell lymphoma]] | ||
*[[Extranodal NK/T-cell lymphoma, nasal type]] | *[[Extranodal NK/T-cell lymphoma, nasal type]] | ||
| + | *[[Gestational trophoblastic neoplasia]] | ||
*[[Head and neck cancer]] | *[[Head and neck cancer]] | ||
*[[Hemophagocytic lymphohistiocytosis]] | *[[Hemophagocytic lymphohistiocytosis]] | ||
| Line 51: | Line 52: | ||
|Amethopterin | |Amethopterin | ||
|Antifolan | |Antifolan | ||
| − | |||
|Artrait | |Artrait | ||
|Biometrox | |Biometrox | ||
|Biotrexate | |Biotrexate | ||
| + | |Caditrex | ||
|- | |- | ||
| − | |||
|Cytotrexate | |Cytotrexate | ||
|Ebetrexat | |Ebetrexat | ||
|Emthexat | |Emthexat | ||
|Emthexate | |Emthexate | ||
| − | |||
| − | |||
|Ervemin | |Ervemin | ||
| − | |||
|Farmitrexat | |Farmitrexat | ||
|Fauldmetro | |Fauldmetro | ||
|Folex PFS | |Folex PFS | ||
| + | |- | ||
|Folitrax | |Folitrax | ||
|Hextrate | |Hextrate | ||
| Line 73: | Line 71: | ||
|Imutrex | |Imutrex | ||
|Ledertrexate | |Ledertrexate | ||
| − | |||
|Ledertrexato | |Ledertrexato | ||
|Lumexon | |Lumexon | ||
|Matrex | |Matrex | ||
| + | |- | ||
|Maxtrex | |Maxtrex | ||
|Medsatrexate | |Medsatrexate | ||
| Line 82: | Line 80: | ||
|Metex | |Metex | ||
|Methobax | |Methobax | ||
| − | |||
|Methoblastin | |Methoblastin | ||
|Methorex | |Methorex | ||
|Methotrexaat | |Methotrexaat | ||
| + | |- | ||
|Methotrexat | |Methotrexat | ||
|Methotrexato | |Methotrexato | ||
| Line 91: | Line 89: | ||
|Meticil | |Meticil | ||
|Metolate | |Metolate | ||
| − | |||
|Metotressato | |Metotressato | ||
|Metotrexate | |Metotrexate | ||
|Metotrexato | |Metotrexato | ||
| + | |- | ||
|Metotrexol | |Metotrexol | ||
|Metrex | |Metrex | ||
| Line 100: | Line 98: | ||
|Metrexato | |Metrexato | ||
|Metrotex | |Metrotex | ||
| − | |||
|Mexate | |Mexate | ||
|Miantrex CS | |Miantrex CS | ||
|MTX | |MTX | ||
| − | | | + | |- |
|Neometho | |Neometho | ||
|Neotrexate | |Neotrexate | ||
|Novatrex | |Novatrex | ||
|Oncotrex | |Oncotrex | ||
| − | |||
| − | |||
|O Trexat | |O Trexat | ||
| − | |||
|Pharmatrexate | |Pharmatrexate | ||
| − | |||
|Remtrex | |Remtrex | ||
|Reumatrex | |Reumatrex | ||
| + | |- | ||
|Rextop | |Rextop | ||
| − | |||
|Rheumatrex | |Rheumatrex | ||
|Tecnomet | |Tecnomet | ||
|Texate | |Texate | ||
| − | |||
|Texorate | |Texorate | ||
|Tratoben | |Tratoben | ||
| − | |||
|Tremetex | |Tremetex | ||
| + | |Trexall | ||
|- | |- | ||
| − | |||
|Trexan | |Trexan | ||
|Trexeron | |Trexeron | ||
|Trixilem | |Trixilem | ||
| − | |||
|Unitrexate | |Unitrexate | ||
| − | |||
|Zexate | |Zexate | ||
|- | |- | ||
| Line 164: | Line 153: | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
[[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | [[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | ||
| + | [[Category:Gestational trophoblastic neoplasia medications]] | ||
[[Category:Head and neck cancer medications]] | [[Category:Head and neck cancer medications]] | ||
[[Category:Hemophagocytic lymphohistiocytosis medications]] | [[Category:Hemophagocytic lymphohistiocytosis medications]] | ||
Revision as of 15:09, 1 February 2018
General information
Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2][3][4][5][6][7]
Route: IV, PO, IM, IT, SC, intraarterial
Extravasation: inflammitant
- Glucarpidase (Voraxaze) can be used to treat toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute promyelocytic leukemia
- Adult T-cell leukemia-lymphoma
- B-cell acute lymphoblastic leukemia
- Bladder cancer
- Breast cancer
- Burkitt lymphoma
- CNS leukemia
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Extranodal NK/T-cell lymphoma, nasal type
- Gestational trophoblastic neoplasia
- Head and neck cancer
- Hemophagocytic lymphohistiocytosis
- HIV-associated lymphoma
- Langerhans cell histiocytosis
- Large granular lymphocytic leukemia
- Mantle cell lymphoma
- NK/T-cell lymphoma
- Osteosarcoma
- Penile cancer
- Peripheral T-cell lymphoma
- Prostate cancer
- Small cell lung cancer
- T-cell acute lymphoblastic leukemia
- Transplant conditioning regimens
Patient drug information
- Methotrexate (Otrexup) subcutaneous injection package insert[5]
- Methotrexate (MTX) patient drug information (Chemocare)[8]
- Methotrexate (MTX) patient drug information (UpToDate)[9]
History of changes in FDA indication
- 12/7/1953: Initial FDA approval
Also known as
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Abitrexate | Alltrex | Amethopterin | Antifolan | Artrait | Biometrox | Biotrexate | Caditrex |
| Cytotrexate | Ebetrexat | Emthexat | Emthexate | Ervemin | Farmitrexat | Fauldmetro | Folex PFS |
| Folitrax | Hextrate | Ifamet | Imutrex | Ledertrexate | Ledertrexato | Lumexon | Matrex |
| Maxtrex | Medsatrexate | Merex | Metex | Methobax | Methoblastin | Methorex | Methotrexaat |
| Methotrexat | Methotrexato | Methotrexatum | Meticil | Metolate | Metotressato | Metotrexate | Metotrexato |
| Metotrexol | Metrex | Metrexan | Metrexato | Metrotex | Mexate | Miantrex CS | MTX |
| Neometho | Neotrexate | Novatrex | Oncotrex | O Trexat | Pharmatrexate | Remtrex | Reumatrex |
| Rextop | Rheumatrex | Tecnomet | Texate | Texorate | Tratoben | Tremetex | Trexall |
| Trexan | Trexeron | Trixilem | Unitrexate | Zexate | |||
References
- ↑ 1.0 1.1 Methotrexate (MTX) tablet package insert
- ↑ Methotrexate (MTX) tablet package insert (locally hosted backup)
- ↑ Methotrexate (MTX) injection package insert
- ↑ Methotrexate (MTX) injection package insert (locally hosted backup)
- ↑ 5.0 5.1 Methotrexate (Otrexup) subcutaneous injection package insert
- ↑ Methotrexate (Otrexup) subcutaneous injection package insert (locally hosted backup)
- ↑ Otrexup manufacturer's website
- ↑ Methotrexate (MTX) patient drug information (Chemocare)
- ↑ Methotrexate (MTX) patient drug information (UpToDate)
Categories:
- Drug index
- Intramuscular medications
- Intrathecal medications
- Intravenous medications
- Oral medications
- Subcutaneous medications
- Inflammitant chemotherapy
- Antimetabolites
- Antifolates
- Immunosuppressants
- Acute promyelocytic leukemia medications
- Adult T-cell leukemia-lymphoma medications
- B-cell acute lymphoblastic leukemia medications
- Bladder cancer medications
- Breast cancer medications
- Burkitt lymphoma medications
- CNS lymphoma medications
- CNS leukemia medications
- Diffuse large B-cell lymphoma medications
- Extranodal NK/T-cell lymphoma, nasal type medications
- Gestational trophoblastic neoplasia medications
- Head and neck cancer medications
- Hemophagocytic lymphohistiocytosis medications
- HIV-associated lymphoma medications
- Langerhans cell histiocytosis medications
- Large granular lymphocytic leukemia medications
- Mantle cell lymphoma medications
- NK/T-cell lymphoma medications
- Osteosarcoma medications
- Penile cancer medications
- Peripheral T-cell lymphoma medications
- Prostate cancer medications
- Small cell lung cancer medications
- Transplant medications
- Drugs FDA approved in 1953
- WHO Essential Cancer Medicine