Difference between revisions of "Chlorambucil (Leukeran)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
− | *[[Chronic lymphocytic leukemia (CLL | + | *[[Chronic lymphocytic leukemia (CLL/SLL)]] |
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
*[[Follicular lymphoma]] | *[[Follicular lymphoma]] | ||
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[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
− | [[Category:Chronic lymphocytic leukemia (CLL | + | [[Category:Chronic lymphocytic leukemia (CLL/SLL) medications]] |
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
[[Category:Follicular lymphoma medications]] | [[Category:Follicular lymphoma medications]] |
Revision as of 15:05, 14 October 2017
General information
Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Chronic lymphocytic leukemia (CLL/SLL)
- Hodgkin lymphoma
- Follicular lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma
- Waldenström macroglobulinemia
Patient drug information
- Chlorambucil (Leukeran) patient drug information (Chemocare)[3]
- Chlorambucil (Leukeran) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/18/1957: Initial FDA approval
Also known as
Precise Name: Chlorambucil (RXCUI 2346)
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Chloraminophene | Chlorambusil | Chlorobutin | Chlorbutin | Leukeran | Linfoxan |
References
- Drug index
- Chemotherapy
- Oral medications
- Nitrogen mustards
- Alkylating agents
- Chronic lymphocytic leukemia (CLL/SLL) medications
- Hodgkin lymphoma medications
- Follicular lymphoma medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 1957
- WHO Essential Cancer Medicine