Difference between revisions of "Azacitidine (Vidaza)"
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| + | Also known as 5-azacitidine or 5-azacytidine. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Pyrimidine nucleoside analog of cytidine, causes hypomethylation of DNA and direct cytotoxicity on abnormal | + | Class/mechanism: Pyrimidine nucleoside analog of cytidine, causes hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. Hypomethylation may restore normal function to genes that are critical for differentiation and proliferation.<ref name="insert">[http://www.vidaza.com/pdf/PI_FINAL.pdf Azacitidine (Vidaza) package insert]</ref><ref>[[Media:Azacitidine.pdf | Azacitidine (Vidaza) package insert (locally hosted backup)]]</ref> |
| − | hematopoietic cells in the bone marrow. Hypomethylation may restore normal function to genes that are critical for differentiation and proliferation.<ref name="insert">[http://www.vidaza.com/pdf/PI_FINAL.pdf Azacitidine (Vidaza) package insert]</ref><ref>[ | ||
<br>Route: IV, SC | <br>Route: IV, SC | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute myeloid leukemia]] | ||
| + | *[[Myelodysplastic syndrome]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/azacitidine.aspx Azacitidine (Vidaza) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/azacitidine.aspx Azacitidine (Vidaza) patient drug information (Chemocare)]</ref> |
| + | *Brief patient counseling information can be found on [http://www.vidaza.com/pdf/PI_FINAL.pdf#page=7 page 7 of the package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/azacitidine-patient-drug-information Azacitidine (Vidaza) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Azacitidine (Vidaza) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/azacitidine-patient-drug-information Azacitidine (Vidaza) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Azacitidine (Vidaza) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 17:16, 7 October 2012
Also known as 5-azacitidine or 5-azacytidine.
General information
Class/mechanism: Pyrimidine nucleoside analog of cytidine, causes hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. Hypomethylation may restore normal function to genes that are critical for differentiation and proliferation.[1][2]
Route: IV, SC
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Azacitidine (Vidaza) patient drug information (Chemocare)[3]
- Brief patient counseling information can be found on page 7 of the package insert[1]
- Azacitidine (Vidaza) patient drug information (UpToDate)[4]