Difference between revisions of "Pentraxin 2 (PRM-151)"
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==General information== | ==General information== | ||
| − | Class/mechanism per [ | + | Class/mechanism per [https://www.cancer.gov/publications/dictionaries/cancer-drug?CdrID=755555 NCI Drug Dictionary]: A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid P/pentraxin 2 (PRM-151) may inhibit myofibroblast generation by preventing the differentiation of circulating monocytes into fibrocytes and profibrotic macrophages. PTX2 is a circulating plasma protein that belongs to the class of pattern recognition receptors (PRR) of the innate immune system. |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
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[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
| + | [[Category:Recombinant medications]] | ||
[[Category:Myelofibrosis medications (investigational)]] | [[Category:Myelofibrosis medications (investigational)]] | ||
Latest revision as of 20:21, 27 June 2024
General information
Class/mechanism per NCI Drug Dictionary: A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid P/pentraxin 2 (PRM-151) may inhibit myofibroblast generation by preventing the differentiation of circulating monocytes into fibrocytes and profibrotic macrophages. PTX2 is a circulating plasma protein that belongs to the class of pattern recognition receptors (PRR) of the innate immune system.
Route: IV
Extravasation: n/a
Preliminary data
Myelofibrosis
Also known as
- Code name: PRM-151