Difference between revisions of "Mitotane (Lysodren)"
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://packageinserts.bms.com/pi/pi_lysodren.pdf Mitotane (Lysodren) package insert]</ref><ref>[ | + | Class/mechanism: Adrenal cytotoxic agent, suppresses adrenal cortex and the extra-adrenal metabolism of cortisol.<ref name="insert">[http://packageinserts.bms.com/pi/pi_lysodren.pdf Mitotane (Lysodren) package insert]</ref><ref>[[:File:Mitotane.pdf | Mitotane (Lysodren) package insert (locally hosted backup)]]</ref> |
| − | <br>Route: | + | <br>Route: PO |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.<ref name="insert"></ref> |
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Adrenocortical carcinoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
*[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitotane-patient-drug-information Mitotane (Lysodren) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==History of changes in FDA indication== | ||
| + | *1970-07-08: Approved for the treatment of inoperable, functional or nonfunctional, [[Adrenocortical carcinoma|adrenal cortical carcinoma]]. | ||
| + | |||
| + | ==History of changes in EMA indication== | ||
| + | *2004-04-28: Indicated for symptomatic treatment of advanced (unresectable, metastatic or relapsed) [[Adrenocortical carcinoma|adrenal cortical carcinoma]]. The effect of Lysodren on non-functional adrenal cortical carcinoma is not established. ''(No supporting studies are cited)'' | ||
| + | |||
| + | ==Also known as== | ||
| + | *'''Generic name:''' o,p'-DDD | ||
| + | *'''Brand name:''' Lysodren | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drugs]] | ||
| + | |||
| + | [[Category:Oral medications]] | ||
| + | [[Category:Adrenal suppressant]] | ||
| + | |||
| + | [[Category:Adrenocortical carcinoma medications]] | ||
| + | |||
| + | [[Category:FDA approved in 1970]] | ||
Latest revision as of 00:59, 29 June 2024
General information
Class/mechanism: Adrenal cytotoxic agent, suppresses adrenal cortex and the extra-adrenal metabolism of cortisol.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.[1]
Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 1970-07-08: Approved for the treatment of inoperable, functional or nonfunctional, adrenal cortical carcinoma.
History of changes in EMA indication
- 2004-04-28: Indicated for symptomatic treatment of advanced (unresectable, metastatic or relapsed) adrenal cortical carcinoma. The effect of Lysodren on non-functional adrenal cortical carcinoma is not established. (No supporting studies are cited)
Also known as
- Generic name: o,p'-DDD
- Brand name: Lysodren