Difference between revisions of "Raltitrexed (Tomudex)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Antimetabolite, inhibitor of thymidylate synthase. Raltitrexed is a quinazoline folate | + | Class/mechanism: Antimetabolite, inhibitor of thymidylate synthase. Raltitrexed is a quinazoline folate analog which inhibits thymidylate synthase (TS). TSis an enzyme involved in the synthesis of thymidine triphosphate (TTP), a nucleotide required exclusively for DNA synthesis. Inhibiting TS causes DNA damage and cell death.<ref name="insert">[https://www.cancercareontario.ca/file/2481/download?token=xvtyZEaB Raltitrexed (Tomudex) package insert]</ref><ref>[[:File:fluorouracil.pdf | Raltitrexed (Tomudex) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *[[ | + | *[[Colorectal cancer]] |
| + | ==History of changes in EMA indication== | ||
| + | *1995-11-08: EURD | ||
==Also known as== | ==Also known as== | ||
| − | *'''Code names:''' TDX, ZD 1694 | + | *'''Code names:''' TDX, ZD-1694 |
*'''Generic name:''' raltitrexed disodium | *'''Generic name:''' raltitrexed disodium | ||
*'''Brand name:''' Tomudex | *'''Brand name:''' Tomudex | ||
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[[Category:Antifolates]] | [[Category:Antifolates]] | ||
| − | [[Category: | + | [[Category:Colorectal cancer medications]] |
[[Category:Malignant pleural mesothelioma medications]] | [[Category:Malignant pleural mesothelioma medications]] | ||
| − | [[Category:EMA approved | + | [[Category:EMA approved in 1995]] |
[[Category:Health Canada approved drugs]] | [[Category:Health Canada approved drugs]] | ||
Latest revision as of 00:14, 6 July 2024
General information
Class/mechanism: Antimetabolite, inhibitor of thymidylate synthase. Raltitrexed is a quinazoline folate analog which inhibits thymidylate synthase (TS). TSis an enzyme involved in the synthesis of thymidine triphosphate (TTP), a nucleotide required exclusively for DNA synthesis. Inhibiting TS causes DNA damage and cell death.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.[1]
Patient drug information
No information available.
Diseases for which it is established (work in progress)
Diseases for which it is used
History of changes in EMA indication
- 1995-11-08: EURD
Also known as
- Code names: TDX, ZD-1694
- Generic name: raltitrexed disodium
- Brand name: Tomudex