Difference between revisions of "Warfarin (Coumadin)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.<ref name="insert">[http://packageinserts.bms.com/pi/pi_coumadin.pdf Warfarin (Coumadin) package insert]</ref><ref>[[ | + | Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.<ref name="insert">[http://packageinserts.bms.com/pi/pi_coumadin.pdf Warfarin (Coumadin) package insert]</ref><ref>[[:File:Warfarin.pdf | Warfarin (Coumadin) package insert (locally hosted backup)]]</ref><ref>[http://www.coumadin.com Coumadin manufacturer's website]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Antiphospholipid antibody syndrome]] | *[[Antiphospholipid antibody syndrome]] | ||
| − | *[[Venous thromboembolism | + | *[[Venous thromboembolism]] |
==Also known as== | ==Also known as== | ||
Latest revision as of 00:06, 6 July 2024
General information
Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.[1]
Patient drug information
Diseases for which it is used
Also known as
- Generic name: warfarina sodica
- Brand names:
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Aldocumar | Anasmol | Anticoag | Arefarin | Athrombin-K | Befarin | Caumadin | Cicoxil |
| Circuvit | Coumadin | Coumadine | Couparin | Dagonal | Farin | Ferevan | Fericard |
| Haemofarin | Jantoven | Kovar | Lawarin | Maforan | Marfarin | Marivanil | Marivarin |
| Orfarin | Panwarfin | Panwarfine | Romesa | Samofaron | Simarc | Tedicumar | Varfarins |
| Varfine | Waran | Warf | Warfa | Warfant | Warfar | Warfarex | Warfil |
| Warfilone | Warfin | Warin | Warlin | Warnerin | Werifrin | ||