Difference between revisions of "Antithymocyte globulin, rabbit ATG (Thymoglobulin)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Contains antibodies against T-cell markers including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, Beta-2 microglobulin, HLA Class I heavy chains, and HLA-DR. Exact mechanism not understood, but may involve removing T-cells from circulation and modifying T-cell activation, migration, proliferation, and cytotoxic effects.<ref name="insert">[http://www.thymoglobulin.com/home/thymo_pdf_pi.pdf Antithymocyte globulin, rabbit ATG (Thymoglobulin) package insert]</ref><ref>[[ | + | Class/mechanism: Contains antibodies against T-cell markers including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, Beta-2 microglobulin, HLA Class I heavy chains, and HLA-DR. Exact mechanism not understood, but may involve removing T-cells from circulation and modifying T-cell activation, migration, proliferation, and cytotoxic effects.<ref name="insert">[http://www.thymoglobulin.com/home/thymo_pdf_pi.pdf Antithymocyte globulin, rabbit ATG (Thymoglobulin) package insert]</ref><ref>[[File:Antithymocyteglobulinrabbit.pdf | Antithymocyte globulin, rabbit ATG (Thymoglobulin) package insert (locally hosted backup)]]</ref><ref>[http://www.thymoglobulin.com/ Thymoglobulin manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, [https://online.lexi.com/lco/action/login UpToDate Lexidrug], [http://reference.medscape.com/drug/atgam-atg-equine-antithymocyte-globulin-equine-343190 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Aplastic anemia]] | *[[Aplastic anemia]] | ||
| − | *[[Graft versus host disease | + | *[[Graft versus host disease]] |
*[[Myelodysplastic syndrome]] | *[[Myelodysplastic syndrome]] | ||
| Line 16: | Line 16: | ||
==Also known as== | ==Also known as== | ||
*'''Generic names:''' anti-thymocyte globulin (rabbit), antithymocyte globulin (rabbit), lymphocyte immune globulin (rabbit) | *'''Generic names:''' anti-thymocyte globulin (rabbit), antithymocyte globulin (rabbit), lymphocyte immune globulin (rabbit) | ||
| − | *'''Brand name:''' Thymoglobulin | + | *'''Brand name:''' Imtix, Thymoglobulin |
==References== | ==References== | ||
Latest revision as of 01:54, 29 June 2024
General information
Class/mechanism: Contains antibodies against T-cell markers including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, Beta-2 microglobulin, HLA Class I heavy chains, and HLA-DR. Exact mechanism not understood, but may involve removing T-cells from circulation and modifying T-cell activation, migration, proliferation, and cytotoxic effects.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, UpToDate Lexidrug, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
Also known as
- Generic names: anti-thymocyte globulin (rabbit), antithymocyte globulin (rabbit), lymphocyte immune globulin (rabbit)
- Brand name: Imtix, Thymoglobulin