Difference between revisions of "Trimethoprim-Sulfamethoxazole (Bactrim DS)"
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==General information== | ==General information== | ||
− | Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/17377slr057_Bactrim_lbl.pdf Trimethoprim | + | Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/17377slr057_Bactrim_lbl.pdf Trimethoprim-Sulfamethoxazole (Bactrim DS) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/trimethoprimsulfamethoxazole.pdf Trimethoprim-Sulfamethoxazole (Bactrim DS) package insert (locally hosted backup)]</ref> |
<br>Route: PO, IV | <br>Route: PO, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
− | *[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim | + | *[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)]</ref> |
==Also known as== | ==Also known as== | ||
− | {| | + | *'''Generic names:''' cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS |
+ | *'''Brand names:''' | ||
+ | {| class="wikitable" style="text-align:center;" | ||
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms''' | !colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms''' | ||
|- | |- | ||
Line 19: | Line 21: | ||
|Abetrim | |Abetrim | ||
|Actrim | |Actrim | ||
− | |||
|Aditrim | |Aditrim | ||
+ | |Adrenol | ||
|- | |- | ||
− | |||
|Adtrim | |Adtrim | ||
|Aksotran | |Aksotran | ||
Line 30: | Line 31: | ||
|Alcot | |Alcot | ||
|Allibac | |Allibac | ||
+ | |Altrim | ||
|- | |- | ||
− | |||
|Amazole | |Amazole | ||
|Amoxazol | |Amoxazol | ||
Line 39: | Line 40: | ||
|Anitrim | |Anitrim | ||
|Anprim | |Anprim | ||
+ | |Antibac | ||
|- | |- | ||
− | |||
|Antrim | |Antrim | ||
|Antrimox | |Antrimox | ||
|Apcetrim | |Apcetrim | ||
|APO-Bactotrim | |APO-Bactotrim | ||
− | |||
|APO Sulfatrim | |APO Sulfatrim | ||
|Apotrinelax | |Apotrinelax | ||
− | |||
|Aptrim | |Aptrim | ||
|Aratran | |Aratran | ||
+ | |- | ||
|Ascotran | |Ascotran | ||
− | |Aspen | + | |Aspen |
|Assepium | |Assepium | ||
|Atomexin | |Atomexin | ||
|Avlotrin | |Avlotrin | ||
|B.S. | |B.S. | ||
− | |||
|BAC-Sulfitrin | |BAC-Sulfitrin | ||
|Bacfar | |Bacfar | ||
+ | |- | ||
|Bacidal | |Bacidal | ||
|Bacin | |Bacin | ||
Line 66: | Line 66: | ||
|Bacoprim | |Bacoprim | ||
|Bacotrin | |Bacotrin | ||
− | |||
|Bacprotin | |Bacprotin | ||
|Bacris | |Bacris | ||
+ | |- | ||
|Bacsulfaprin | |Bacsulfaprin | ||
|Bacsultrim | |Bacsultrim | ||
Line 75: | Line 75: | ||
|Bactekod | |Bactekod | ||
|Bactelan | |Bactelan | ||
− | |||
|Bacteracin | |Bacteracin | ||
|Bacterial | |Bacterial | ||
+ | |- | ||
|Bacteric | |Bacteric | ||
|Bacteriof.klebs PN | |Bacteriof.klebs PN | ||
Line 84: | Line 84: | ||
|Bactide | |Bactide | ||
|Bactifor | |Bactifor | ||
− | |||
|Bactigram | |Bactigram | ||
|Bactille-TS | |Bactille-TS | ||
+ | |- | ||
|Bactipront | |Bactipront | ||
|Bactiseptol | |Bactiseptol | ||
|Bactiver | |Bactiver | ||
|Bactoprim | |Bactoprim | ||
− | |||
|Bactoreduct | |Bactoreduct | ||
− | |||
|Bactosain | |Bactosain | ||
|Bactostab | |Bactostab | ||
|Bactramin | |Bactramin | ||
− | | | + | |- |
|Bactricid | |Bactricid | ||
|Bactricida | |Bactricida | ||
|Bactricin | |Bactricin | ||
|Bactrilac | |Bactrilac | ||
− | |||
|Bactrim | |Bactrim | ||
− | |||
− | |||
|Bactrimel | |Bactrimel | ||
− | |||
− | |||
− | |||
− | |||
− | |||
|Bactrin | |Bactrin | ||
|Bactrisan | |Bactrisan | ||
+ | |- | ||
|Bactrium DS | |Bactrium DS | ||
|Bactrizole | |Bactrizole | ||
Line 120: | Line 111: | ||
|Bactropin | |Bactropin | ||
|Bacxal | |Bacxal | ||
− | |||
|Baczin | |Baczin | ||
|Baczole | |Baczole | ||
+ | |- | ||
|Baklinger | |Baklinger | ||
|Baktar | |Baktar | ||
Line 129: | Line 120: | ||
|Balkatrin | |Balkatrin | ||
|Balkatrine | |Balkatrine | ||
− | |||
− | |||
|Bantizol | |Bantizol | ||
|Basatin | |Basatin | ||
+ | |- | ||
|Baserin | |Baserin | ||
|Batrox | |Batrox | ||
|Baxolex | |Baxolex | ||
|Belfactrin | |Belfactrin | ||
− | |||
− | |||
|Bencole | |Bencole | ||
|Benectrin | |Benectrin | ||
− | |||
|Berlocid | |Berlocid | ||
|Bestofens | |Bestofens | ||
+ | |- | ||
|Bethaprim | |Bethaprim | ||
− | |||
|Bibakrim | |Bibakrim | ||
− | |||
|Bicotrim | |Bicotrim | ||
|Bimatrim | |Bimatrim | ||
− | |||
|Bioprim | |Bioprim | ||
|Biosulten | |Biosulten | ||
|Biotran | |Biotran | ||
|Biotrim | |Biotrim | ||
+ | |- | ||
|Biotrin | |Biotrin | ||
− | |||
|Biprim | |Biprim | ||
|Biseptin | |Biseptin | ||
Line 164: | Line 149: | ||
|Bisultrim | |Bisultrim | ||
|Bitrim | |Bitrim | ||
+ | |- | ||
|Blexon | |Blexon | ||
− | |||
− | |||
|Boschtrim | |Boschtrim | ||
|Brifeseptol | |Brifeseptol | ||
Line 189: | Line 173: | ||
|Cipaprim | |Cipaprim | ||
|Ciplin | |Ciplin | ||
− | |||
|Citrim | |Citrim | ||
|Cladon | |Cladon | ||
+ | |Clinitran | ||
|- | |- | ||
− | |||
|Clonea | |Clonea | ||
|Clotrizol | |Clotrizol | ||
− | |||
|CO-Sultrin | |CO-Sultrin | ||
|CO-Tasian | |CO-Tasian | ||
|CO-Traisole 480 | |CO-Traisole 480 | ||
|CO-Trim-Tablinen | |CO-Trim-Tablinen | ||
− | |||
|CO-Trimazole | |CO-Trimazole | ||
|CO-Trimed | |CO-Trimed | ||
− | | | + | |- |
|CO-Trimoxa | |CO-Trimoxa | ||
− | |CO-Trimoxazol | + | |CO-Trimoxazol |
− | |||
− | |||
− | |||
− | |||
|Cobact | |Cobact | ||
|Cobal ST | |Cobal ST | ||
Line 217: | Line 194: | ||
|Colitran | |Colitran | ||
|Colizole | |Colizole | ||
+ | |- | ||
|Colotrim | |Colotrim | ||
|Comax | |Comax | ||
− | |||
|Comazole | |Comazole | ||
− | |||
|Combact | |Combact | ||
|Combi-Methoxan | |Combi-Methoxan | ||
Line 227: | Line 203: | ||
|Comox | |Comox | ||
|Comoxol | |Comoxol | ||
+ | |- | ||
|Contrimoxazole | |Contrimoxazole | ||
− | |||
|Coprim | |Coprim | ||
|Coprime | |Coprime | ||
Line 236: | Line 212: | ||
|Cosulf | |Cosulf | ||
|Cotoram | |Cotoram | ||
+ | |- | ||
|Cotran | |Cotran | ||
− | |||
|Cotrazen | |Cotrazen | ||
|Cotrexel | |Cotrexel | ||
Line 245: | Line 221: | ||
|Cotribid | |Cotribid | ||
|Cotril | |Cotril | ||
− | |||
|- | |- | ||
|Cotrilin | |Cotrilin | ||
|Cotrim | |Cotrim | ||
− | |||
− | |||
− | |||
− | |||
|Cotrimax | |Cotrimax | ||
|Cotrimaxazol | |Cotrimaxazol | ||
− | |||
|Cotrimaxazole | |Cotrimaxazole | ||
− | |||
− | |||
|Cotrimel | |Cotrimel | ||
− | |||
− | |||
− | |||
|Cotrimhexal | |Cotrimhexal | ||
+ | |Cotrimol | ||
|- | |- | ||
− | |||
− | |||
|Cotrimox | |Cotrimox | ||
|Cotrimoxazol | |Cotrimoxazol | ||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
|Cotrimoxin | |Cotrimoxin | ||
− | |||
− | |||
|Cotrimstada | |Cotrimstada | ||
|Cotripharm | |Cotripharm | ||
Line 288: | Line 239: | ||
|Cotrixyl-L | |Cotrixyl-L | ||
|Cotrizol | |Cotrizol | ||
− | | | + | |- |
|Cotrizole | |Cotrizole | ||
|Cots | |Cots | ||
− | |||
|Cozol | |Cozol | ||
|Cozole | |Cozole | ||
Line 298: | Line 248: | ||
|Daiphen | |Daiphen | ||
|Decatrim | |Decatrim | ||
+ | |- | ||
|Deotrim | |Deotrim | ||
|Dertrin | |Dertrin | ||
− | |||
|Dhatrin | |Dhatrin | ||
|Dino-BAC | |Dino-BAC | ||
|Diseptyl | |Diseptyl | ||
− | |||
− | |||
|Doctrim | |Doctrim | ||
|Dosatran | |Dosatran | ||
Line 325: | Line 273: | ||
|Dynaprim | |Dynaprim | ||
|Ectaprim | |Ectaprim | ||
− | |||
|Ectrin | |Ectrin | ||
+ | |Editrim | ||
|- | |- | ||
− | |||
|Eduprim | |Eduprim | ||
|Eliprim | |Eliprim | ||
Line 336: | Line 283: | ||
|Esbesul | |Esbesul | ||
|Escoprim | |Escoprim | ||
+ | |Espectrin | ||
|- | |- | ||
− | |||
|Espectroprima | |Espectroprima | ||
|Ethitrim | |Ethitrim | ||
Line 345: | Line 292: | ||
|Exazol | |Exazol | ||
|Fabubac | |Fabubac | ||
+ | |Fakzol | ||
|- | |- | ||
− | |||
|Falprim | |Falprim | ||
|Fameprim | |Fameprim | ||
Line 354: | Line 301: | ||
|Flatran | |Flatran | ||
|Flocot | |Flocot | ||
+ | |Forcrim | ||
|- | |- | ||
− | |||
|Forteprim | |Forteprim | ||
− | |||
|Gamactrin | |Gamactrin | ||
|Gatrima | |Gatrima | ||
Line 363: | Line 309: | ||
|Genoxzole | |Genoxzole | ||
|Gentrim | |Gentrim | ||
− | |||
|Genzaprim | |Genzaprim | ||
|Getrim | |Getrim | ||
+ | |- | ||
|Globaxol | |Globaxol | ||
|Gobens Trim | |Gobens Trim | ||
Line 372: | Line 318: | ||
|Gunametrim | |Gunametrim | ||
|Hatrix | |Hatrix | ||
− | |||
− | |||
|Helveprim | |Helveprim | ||
|Herixina | |Herixina | ||
+ | |- | ||
|Hexaprim | |Hexaprim | ||
|Hicot | |Hicot | ||
Line 381: | Line 326: | ||
|Huma-Trimel | |Huma-Trimel | ||
|Ibtrim | |Ibtrim | ||
− | |||
|Imcotran | |Imcotran | ||
|Imexim | |Imexim | ||
|Inatrim | |Inatrim | ||
+ | |- | ||
|Infatrim | |Infatrim | ||
|Infectran | |Infectran | ||
|Infectrim | |Infectrim | ||
|Infectrin | |Infectrin | ||
− | |||
− | |||
|Infesin | |Infesin | ||
|Intrafort | |Intrafort | ||
|Introcin | |Introcin | ||
|Irgagen | |Irgagen | ||
+ | |- | ||
|Isoprim | |Isoprim | ||
|Isotrim | |Isotrim | ||
|Japtrim | |Japtrim | ||
|Jasotrim | |Jasotrim | ||
− | |||
|Jenamoxazol | |Jenamoxazol | ||
|Jestrim | |Jestrim | ||
|Justeprim | |Justeprim | ||
|K.B.famate | |K.B.famate | ||
+ | |- | ||
|Kaftrim | |Kaftrim | ||
|Kathrex | |Kathrex | ||
|Katrim | |Katrim | ||
|Kaytran | |Kaytran | ||
− | |||
|Kemocid | |Kemocid | ||
|Kemoprim | |Kemoprim | ||
|Kentricid | |Kentricid | ||
|Kepinol | |Kepinol | ||
+ | |- | ||
|Kindoprim | |Kindoprim | ||
|KO-Kure | |KO-Kure | ||
|Kombina | |Kombina | ||
|Kotazol | |Kotazol | ||
− | |||
|Kotrimoksazol | |Kotrimoksazol | ||
|Krobactrol | |Krobactrol | ||
|L-Trim | |L-Trim | ||
|Lacreozole | |Lacreozole | ||
− | | | + | |- |
− | | Lagatrim | + | |Lagatrim |
|Lapikot | |Lapikot | ||
|Laratrim | |Laratrim | ||
− | |||
|Larprim | |Larprim | ||
|Lastrim | |Lastrim | ||
Line 432: | Line 374: | ||
|Leprim | |Leprim | ||
|Lescot | |Lescot | ||
+ | |- | ||
|Letus | |Letus | ||
|Lictora | |Lictora | ||
|Lifactrin | |Lifactrin | ||
− | |||
|Lifzol | |Lifzol | ||
|Lisaprin | |Lisaprin | ||
Line 441: | Line 383: | ||
|Lobact | |Lobact | ||
|Longasal | |Longasal | ||
+ | |- | ||
|Lupectrin | |Lupectrin | ||
|Lusaprim | |Lusaprim | ||
|Lykaprim | |Lykaprim | ||
− | |||
|M-Moxa | |M-Moxa | ||
|M-Trim | |M-Trim | ||
Line 450: | Line 392: | ||
|Macromed | |Macromed | ||
|Mactran | |Mactran | ||
+ | |- | ||
|Madroxin | |Madroxin | ||
|Maktrim | |Maktrim | ||
|Martiprim | |Martiprim | ||
− | |||
|Maxaprim | |Maxaprim | ||
|Maxiprim | |Maxiprim | ||
|Maxitrin | |Maxitrin | ||
− | |||
|Maxol | |Maxol | ||
|Maxtrim | |Maxtrim | ||
+ | |- | ||
|Maxzol | |Maxzol | ||
|Mazatrim | |Mazatrim | ||
− | |||
|Mebryn | |Mebryn | ||
|Medcotrim | |Medcotrim | ||
− | |||
|Mediprim | |Mediprim | ||
|Meditran | |Meditran | ||
|Meditrim | |Meditrim | ||
|Medtrim | |Medtrim | ||
+ | |- | ||
|Megabroncoflam | |Megabroncoflam | ||
− | |||
|Megaset | |Megaset | ||
|Megatrim | |Megatrim | ||
|Meprim | |Meprim | ||
|Meprotrin | |Meprotrin | ||
− | |||
|Methoprim | |Methoprim | ||
|Methotrin | |Methotrin | ||
Line 484: | Line 423: | ||
|Metoxiprim | |Metoxiprim | ||
|Metrim | |Metrim | ||
− | |||
− | |||
|Metxaprim | |Metxaprim | ||
|Mexaprim | |Mexaprim | ||
|Mexazole | |Mexazole | ||
− | |||
|Mezenol | |Mezenol | ||
|Micinovo | |Micinovo | ||
+ | |- | ||
|Micogyl | |Micogyl | ||
− | |||
|Microbid | |Microbid | ||
− | |||
|Microcetim | |Microcetim | ||
− | |||
− | |||
|Microdyn | |Microdyn | ||
|Microsupos Amigdalar | |Microsupos Amigdalar | ||
Line 504: | Line 437: | ||
|Mikotrim | |Mikotrim | ||
|Mikrosid | |Mikrosid | ||
+ | |- | ||
|Miratrim | |Miratrim | ||
|Moly | |Moly | ||
|Mortin | |Mortin | ||
− | |||
|Moxadden | |Moxadden | ||
|Moxalas | |Moxalas | ||
Line 513: | Line 446: | ||
|Moxzole | |Moxzole | ||
|Mukadryl | |Mukadryl | ||
+ | |- | ||
|Myctrim | |Myctrim | ||
|Naftran | |Naftran | ||
|Napatrim | |Napatrim | ||
− | |||
|Navatrim | |Navatrim | ||
|Necorzole | |Necorzole | ||
Line 522: | Line 455: | ||
|Neotrim | |Neotrim | ||
|Netocur | |Netocur | ||
+ | |- | ||
|Neuroprim | |Neuroprim | ||
|Nicotrim | |Nicotrim | ||
|Nilium | |Nilium | ||
− | |||
|Nodilon | |Nodilon | ||
|Nopil | |Nopil | ||
Line 531: | Line 464: | ||
|Nortrim | |Nortrim | ||
|Nortrime | |Nortrime | ||
+ | |- | ||
|Notrim | |Notrim | ||
|Notrime | |Notrime | ||
|Novactil | |Novactil | ||
− | |||
|Novidrine | |Novidrine | ||
|Novotrimel | |Novotrimel | ||
− | |||
|Novotrimox | |Novotrimox | ||
|Novotrim Plus | |Novotrim Plus | ||
|Novozole | |Novozole | ||
− | |||
− | |||
|- | |- | ||
|Nucotrim | |Nucotrim | ||
|Nufaprim | |Nufaprim | ||
− | |||
|Nuruzole | |Nuruzole | ||
|Octil-S | |Octil-S | ||
Line 552: | Line 481: | ||
|Octrim | |Octrim | ||
|Oecotrim | |Oecotrim | ||
+ | |Okatrim | ||
|- | |- | ||
− | |||
|Omegtrim | |Omegtrim | ||
|Omnatrim | |Omnatrim | ||
Line 561: | Line 490: | ||
|Orbak | |Orbak | ||
|Orgastran | |Orgastran | ||
+ | |Oribact | ||
|- | |- | ||
− | |||
|Ormoprim | |Ormoprim | ||
|Ostrin Forte | |Ostrin Forte | ||
Line 570: | Line 499: | ||
|Pakzole | |Pakzole | ||
|Pantrim | |Pantrim | ||
+ | |Patrim | ||
|- | |- | ||
− | |||
|Pehatrim | |Pehatrim | ||
|Penetrin | |Penetrin | ||
|Pentrin | |Pentrin | ||
|Penzole | |Penzole | ||
− | |||
|Pharmatrim | |Pharmatrim | ||
|Pharmazol | |Pharmazol | ||
− | |||
|Phartex | |Phartex | ||
|Pisatrina | |Pisatrina | ||
+ | |- | ||
|Plurisul | |Plurisul | ||
|Polibatrin | |Polibatrin | ||
Line 588: | Line 516: | ||
|Pribac | |Pribac | ||
|Primadex | |Primadex | ||
− | |||
|Primasul | |Primasul | ||
|Primasulf | |Primasulf | ||
+ | |- | ||
|Primatrim | |Primatrim | ||
|Primavon | |Primavon | ||
|Primazol | |Primazol | ||
|Primazole | |Primazole | ||
− | |||
|Primotren | |Primotren | ||
− | |||
|Primox | |Primox | ||
|Primsulfon | |Primsulfon | ||
|Primzole | |Primzole | ||
+ | |- | ||
|Protrin | |Protrin | ||
− | |||
|Pulkrin | |Pulkrin | ||
|Purbac | |Purbac | ||
− | |||
− | |||
|Qiftrim | |Qiftrim | ||
|Qiftrin | |Qiftrin | ||
Line 612: | Line 536: | ||
|Quisulyn | |Quisulyn | ||
|Rancotrim | |Rancotrim | ||
+ | |- | ||
|Rasat | |Rasat | ||
|Raseptol | |Raseptol | ||
|Ratrim | |Ratrim | ||
− | |||
|Regtin | |Regtin | ||
|Rematrim | |Rematrim | ||
|Renatrim | |Renatrim | ||
|Resprim | |Resprim | ||
− | |||
|Retrim | |Retrim | ||
+ | |- | ||
|Rexaprim | |Rexaprim | ||
|Ribatrim | |Ribatrim | ||
− | |||
|Rimazole | |Rimazole | ||
|Rimezone | |Rimezone | ||
− | |||
|Rivoprim | |Rivoprim | ||
|Rizol | |Rizol | ||
− | |||
|Rolprim | |Rolprim | ||
|Roubac | |Roubac | ||
Line 652: | Line 573: | ||
|Septabid | |Septabid | ||
|- | |- | ||
− | |||
|Septazol | |Septazol | ||
|Septazole | |Septazole | ||
Line 660: | Line 580: | ||
|Septocid R + | |Septocid R + | ||
|Septoprin | |Septoprin | ||
+ | |Septra | ||
|- | |- | ||
− | |||
− | |||
|Septran | |Septran | ||
|Septrin-S | |Septrin-S | ||
|Septrin Paediatric | |Septrin Paediatric | ||
|Servitrim | |Servitrim | ||
− | |||
|Sigaprim | |Sigaprim | ||
− | |||
|Sigatrim | |Sigatrim | ||
|Silpin | |Silpin | ||
|Siltran | |Siltran | ||
+ | |- | ||
|Sinatrim | |Sinatrim | ||
|Sinersul | |Sinersul | ||
Line 678: | Line 596: | ||
|Sisoprim | |Sisoprim | ||
|Sistrim | |Sistrim | ||
− | |||
|Sitrim | |Sitrim | ||
|Skytrin | |Skytrin | ||
|Smartrim | |Smartrim | ||
− | | | + | |- |
− | |||
− | |||
− | |||
|Soltrim | |Soltrim | ||
− | |||
− | |||
|Soptrim | |Soptrim | ||
|Sosetran | |Sosetran | ||
Line 699: | Line 611: | ||
|Suftrex | |Suftrex | ||
|Sulbacta | |Sulbacta | ||
− | |||
− | |||
− | |||
− | |||
|Sulfagrand | |Sulfagrand | ||
|Sulfamer | |Sulfamer | ||
− | |||
|Sulfamet | |Sulfamet | ||
|Sulfamethoprim | |Sulfamethoprim | ||
− | |||
− | |||
− | |||
− | |||
− | |||
|Sulfametoxazol | |Sulfametoxazol | ||
+ | |Sulfaprim | ||
|- | |- | ||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
|Sulfarim | |Sulfarim | ||
|Sulfatalpin | |Sulfatalpin | ||
− | |||
|Sulfaton | |Sulfaton | ||
|Sulfatrim | |Sulfatrim | ||
− | |||
|Sulfatropim | |Sulfatropim | ||
|Sulfawal-T | |Sulfawal-T | ||
|Sulfinam | |Sulfinam | ||
− | |||
|Sulfoid Trimetho | |Sulfoid Trimetho | ||
|- | |- | ||
Line 738: | Line 632: | ||
|Sulfotrim | |Sulfotrim | ||
|Sulfotrimin | |Sulfotrimin | ||
− | |||
|Sulftran | |Sulftran | ||
|Sulgotri | |Sulgotri | ||
+ | |Sulotrim | ||
|- | |- | ||
− | |||
− | |||
|Sulphaprim | |Sulphaprim | ||
|Sulphathoprim | |Sulphathoprim | ||
Line 750: | Line 642: | ||
|Sulphax | |Sulphax | ||
|Sulphytrim Forte | |Sulphytrim Forte | ||
− | |||
− | |||
|Sulprim | |Sulprim | ||
|Sulprimed | |Sulprimed | ||
+ | |- | ||
|Sultase | |Sultase | ||
|Sulthrim | |Sulthrim | ||
− | |||
|Sultiprim | |Sultiprim | ||
|Sultorim | |Sultorim | ||
− | |||
|Sultra | |Sultra | ||
|Sultrex | |Sultrex | ||
|Sultrim | |Sultrim | ||
|Sultrima | |Sultrima | ||
+ | |- | ||
|Sultrimmix | |Sultrimmix | ||
|Sultrivon-F | |Sultrivon-F | ||
|Sultropim | |Sultropim | ||
|Sumetoprim | |Sumetoprim | ||
− | |||
|Sumetrolim | |Sumetrolim | ||
|Sumetrolin | |Sumetrolin | ||
|Sumitran | |Sumitran | ||
|Suntrim | |Suntrim | ||
+ | |- | ||
|Supim | |Supim | ||
|Supracombin | |Supracombin | ||
|Suprasulf | |Suprasulf | ||
|Suprex | |Suprex | ||
− | |||
|Supribac | |Supribac | ||
− | |||
|Suprim | |Suprim | ||
|Suprimass | |Suprimass | ||
|Suprin | |Suprin | ||
+ | |- | ||
|Suptrex | |Suptrex | ||
|Suptrim | |Suptrim | ||
|Sutaprim | |Sutaprim | ||
− | |||
|Sutrim | |Sutrim | ||
|Sutrisan | |Sutrisan | ||
Line 792: | Line 680: | ||
|Syltrifil | |Syltrifil | ||
|Synac | |Synac | ||
+ | |- | ||
|Synastat | |Synastat | ||
|Synbac | |Synbac | ||
|Synco-Smzt | |Synco-Smzt | ||
− | |||
|Syndal | |Syndal | ||
|Synermed | |Synermed | ||
Line 801: | Line 689: | ||
|Synetra | |Synetra | ||
|Synotrim | |Synotrim | ||
+ | |- | ||
|Syntoprim | |Syntoprim | ||
|System | |System | ||
− | |||
− | |||
|Tabrol | |Tabrol | ||
|Tagremin | |Tagremin | ||
Line 811: | Line 698: | ||
|Terbosulfa | |Terbosulfa | ||
|Teutrin | |Teutrin | ||
+ | |- | ||
|Theraprim | |Theraprim | ||
|Therasept | |Therasept | ||
− | |||
|Theratrim | |Theratrim | ||
|Thoprim | |Thoprim | ||
|Thriazol | |Thriazol | ||
− | |||
− | |||
− | |||
|Torrid | |Torrid | ||
|Tprim | |Tprim | ||
+ | |Trelibec | ||
|- | |- | ||
− | |||
|Trib | |Trib | ||
− | |||
|Tricban | |Tricban | ||
|Tricomox | |Tricomox | ||
Line 831: | Line 714: | ||
|Trifides | |Trifides | ||
|Triforam | |Triforam | ||
− | |||
|Trihexal | |Trihexal | ||
|Trim | |Trim | ||
− | | | + | |- |
− | + | |Trima | |
− | | Trima | ||
|Trimaxazole | |Trimaxazole | ||
|Trimel | |Trimel | ||
|Trimephar | |Trimephar | ||
− | |||
|Trimeran | |Trimeran | ||
|Trimerazin | |Trimerazin | ||
|Trimeril | |Trimeril | ||
|Trimesol | |Trimesol | ||
+ | |- | ||
|Trimesul | |Trimesul | ||
|Trimesulf | |Trimesulf | ||
− | |||
|Trimeta | |Trimeta | ||
− | |||
− | |||
− | |||
− | |||
|Trimethox | |Trimethox | ||
|Trimetoger | |Trimetoger | ||
|Trimetop Duplo | |Trimetop Duplo | ||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
|Trimetotal | |Trimetotal | ||
|Trimetox | |Trimetox | ||
+ | |- | ||
|Trimetrin | |Trimetrin | ||
|Trimetsol | |Trimetsol | ||
Line 876: | Line 741: | ||
|Trimexazole | |Trimexazole | ||
|Trimexole-F | |Trimexole-F | ||
− | |||
|Trimezol | |Trimezol | ||
|Trimezole | |Trimezole | ||
+ | |- | ||
|Trimfasul | |Trimfasul | ||
|Trimidar M | |Trimidar M | ||
Line 885: | Line 750: | ||
|Trimoks | |Trimoks | ||
|Trimosul | |Trimosul | ||
− | |||
|Trimosulfa | |Trimosulfa | ||
|Trimoxavin | |Trimoxavin | ||
+ | |- | ||
|Trimoxazol | |Trimoxazol | ||
|Trimoxazole-BC | |Trimoxazole-BC | ||
Line 894: | Line 759: | ||
|Trimoxsul | |Trimoxsul | ||
|Trimozol | |Trimozol | ||
− | |||
|Trimsul | |Trimsul | ||
|Trimzol | |Trimzol | ||
+ | |- | ||
|Triphimox | |Triphimox | ||
|Tripur | |Tripur | ||
Line 903: | Line 768: | ||
|Trisolak Forte | |Trisolak Forte | ||
|Trisolvat | |Trisolvat | ||
− | |||
|Trisul | |Trisul | ||
|Trisulcom | |Trisulcom | ||
+ | |- | ||
|Trisulfa | |Trisulfa | ||
− | |||
|Trisulfose | |Trisulfose | ||
|Trisuprim | |Trisuprim | ||
|Trisural | |Trisural | ||
|Tritenk | |Tritenk | ||
− | |||
− | |||
|Tritosul | |Tritosul | ||
− | |||
|Trixazol | |Trixazol | ||
− | |||
|Trixzol | |Trixzol | ||
+ | |- | ||
|Trizole | |Trizole | ||
|Tryseptolum | |Tryseptolum | ||
− | |||
− | |||
|Tytrim | |Tytrim | ||
|U-Prin | |U-Prin | ||
Line 929: | Line 788: | ||
|Ultrazole | |Ultrazole | ||
|Ultrim | |Ultrim | ||
+ | |- | ||
|Unitran | |Unitran | ||
− | |||
|Uprina | |Uprina | ||
|Urethrax | |Urethrax | ||
Line 938: | Line 797: | ||
|Utrin | |Utrin | ||
|Versatrim | |Versatrim | ||
+ | |- | ||
|Virin | |Virin | ||
− | |||
|Weiditrin | |Weiditrin | ||
|Wiatrim | |Wiatrim | ||
Line 947: | Line 806: | ||
|XA-Zole | |XA-Zole | ||
|Xazotrim | |Xazotrim | ||
+ | |- | ||
|Xepaprim | |Xepaprim | ||
− | |||
|Xerazole | |Xerazole | ||
|Xeroprim | |Xeroprim | ||
Line 956: | Line 815: | ||
|Zantran | |Zantran | ||
|Zaxol | |Zaxol | ||
+ | |- | ||
|Zecatrim | |Zecatrim | ||
− | |||
|Zeptra | |Zeptra | ||
|Zerrprim | |Zerrprim | ||
Line 965: | Line 824: | ||
|Zoltrim | |Zoltrim | ||
|Zultrop | |Zultrop | ||
+ | |- | ||
|} | |} | ||
Line 971: | Line 831: | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
+ | [[Category:Combination drugs]] | ||
[[Category:Oral medications]] | [[Category:Oral medications]] | ||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] |
Latest revision as of 01:48, 29 June 2024
General information
Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.[1][2]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
Also known as
- Generic names: cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS
- Brand names:
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Abacin | Abactrim | Abatrim | Abditri | Abetrim | Actrim | Aditrim | Adrenol |
Adtrim | Aksotran | Albrotran | Albutrim | Alcorim-F | Alcot | Allibac | Altrim |
Amazole | Amoxazol | Amtran | Amtril | Andoprim | Anitrim | Anprim | Antibac |
Antrim | Antrimox | Apcetrim | APO-Bactotrim | APO Sulfatrim | Apotrinelax | Aptrim | Aratran |
Ascotran | Aspen | Assepium | Atomexin | Avlotrin | B.S. | BAC-Sulfitrin | Bacfar |
Bacidal | Bacin | Bacitran | Bacmetrin | Bacoprim | Bacotrin | Bacprotin | Bacris |
Bacsulfaprin | Bacsultrim | Bactar | Bactazol | Bactekod | Bactelan | Bacteracin | Bacterial |
Bacteric | Bacteriof.klebs PN | Bacterol | Bacticel | Bactide | Bactifor | Bactigram | Bactille-TS |
Bactipront | Bactiseptol | Bactiver | Bactoprim | Bactoreduct | Bactosain | Bactostab | Bactramin |
Bactricid | Bactricida | Bactricin | Bactrilac | Bactrim | Bactrimel | Bactrin | Bactrisan |
Bactrium DS | Bactrizole | Bactron | Bactronil | Bactropin | Bacxal | Baczin | Baczole |
Baklinger | Baktar | Bakton | Baktrisid DS | Balkatrin | Balkatrine | Bantizol | Basatin |
Baserin | Batrox | Baxolex | Belfactrin | Bencole | Benectrin | Berlocid | Bestofens |
Bethaprim | Bibakrim | Bicotrim | Bimatrim | Bioprim | Biosulten | Biotran | Biotrim |
Biotrin | Biprim | Biseptin | Biseptol | Biseptrim | Bismoral | Bisultrim | Bitrim |
Blexon | Boschtrim | Brifeseptol | Broncoflam | Brongenit | BS | Canprim | Caretran |
Centrim | Chemitrim | Chemix | Chemizol | Chemoprim | Chemotran | Chemotrim | Chemotrin |
Chemozole | Chromo-Z | Cidaprim | Cipaprim | Ciplin | Citrim | Cladon | Clinitran |
Clonea | Clotrizol | CO-Sultrin | CO-Tasian | CO-Traisole 480 | CO-Trim-Tablinen | CO-Trimazole | CO-Trimed |
CO-Trimoxa | CO-Trimoxazol | Cobact | Cobal ST | Cocydal | Cofatrim | Colitran | Colizole |
Colotrim | Comax | Comazole | Combact | Combi-Methoxan | Comixco | Comox | Comoxol |
Contrimoxazole | Coprim | Coprime | Cosat | Cosig | Costazole | Cosulf | Cotoram |
Cotran | Cotrazen | Cotrexel | Cotri | Cotribase | Cotribene | Cotribid | Cotril |
Cotrilin | Cotrim | Cotrimax | Cotrimaxazol | Cotrimaxazole | Cotrimel | Cotrimhexal | Cotrimol |
Cotrimox | Cotrimoxazol | Cotrimoxin | Cotrimstada | Cotripharm | Cotrisul | Cotrixyl-L | Cotrizol |
Cotrizole | Cots | Cozol | Cozole | Creptrim | Curaprim | Daiphen | Decatrim |
Deotrim | Dertrin | Dhatrin | Dino-BAC | Diseptyl | Doctrim | Dosatran | Drilozole |
Drossul | Droxol | Drylin | Dubac | Dumotrim | Duobact | Duobiocin | Duoctrin |
DUO Septol | Duratrimet | Dutran | Dvaseptol | Dynaprim | Ectaprim | Ectrin | Editrim |
Eduprim | Eliprim | Eroprim | Erotrim | Erphatrim | Esbesul | Escoprim | Espectrin |
Espectroprima | Ethitrim | Eurotrim | Eusaprim | Eutrim | Exazol | Fabubac | Fakzol |
Falprim | Fameprim | Fectrim | Fedimed | Fisat | Flatran | Flocot | Forcrim |
Forteprim | Gamactrin | Gatrima | Genoctrin | Genoxzole | Gentrim | Genzaprim | Getrim |
Globaxol | Gobens Trim | Graprima | Groseptol | Gunametrim | Hatrix | Helveprim | Herixina |
Hexaprim | Hicot | Hufacid | Huma-Trimel | Ibtrim | Imcotran | Imexim | Inatrim |
Infatrim | Infectran | Infectrim | Infectrin | Infesin | Intrafort | Introcin | Irgagen |
Isoprim | Isotrim | Japtrim | Jasotrim | Jenamoxazol | Jestrim | Justeprim | K.B.famate |
Kaftrim | Kathrex | Katrim | Kaytran | Kemocid | Kemoprim | Kentricid | Kepinol |
Kindoprim | KO-Kure | Kombina | Kotazol | Kotrimoksazol | Krobactrol | L-Trim | Lacreozole |
Lagatrim | Lapikot | Laratrim | Larprim | Lastrim | Leotrim | Leprim | Lescot |
Letus | Lictora | Lifactrin | Lifzol | Lisaprin | Litrim | Lobact | Longasal |
Lupectrin | Lusaprim | Lykaprim | M-Moxa | M-Trim | Macprim | Macromed | Mactran |
Madroxin | Maktrim | Martiprim | Maxaprim | Maxiprim | Maxitrin | Maxol | Maxtrim |
Maxzol | Mazatrim | Mebryn | Medcotrim | Mediprim | Meditran | Meditrim | Medtrim |
Megabroncoflam | Megaset | Megatrim | Meprim | Meprotrin | Methoprim | Methotrin | Metoprim |
Metoprin | Metoxiprim | Metrim | Metxaprim | Mexaprim | Mexazole | Mezenol | Micinovo |
Micogyl | Microbid | Microcetim | Microdyn | Microsupos Amigdalar | Microtrim | Mikotrim | Mikrosid |
Miratrim | Moly | Mortin | Moxadden | Moxalas | Moxatrim | Moxzole | Mukadryl |
Myctrim | Naftran | Napatrim | Navatrim | Necorzole | Neoset | Neotrim | Netocur |
Neuroprim | Nicotrim | Nilium | Nodilon | Nopil | Norisep | Nortrim | Nortrime |
Notrim | Notrime | Novactil | Novidrine | Novotrimel | Novotrimox | Novotrim Plus | Novozole |
Nucotrim | Nufaprim | Nuruzole | Octil-S | Octran | Octrim | Oecotrim | Okatrim |
Omegtrim | Omnatrim | Omsat | Onetrim | Oradin | Orbak | Orgastran | Oribact |
Ormoprim | Ostrin Forte | Otrim | Ottoprim | Oxaprim | Pakzole | Pantrim | Patrim |
Pehatrim | Penetrin | Pentrin | Penzole | Pharmatrim | Pharmazol | Phartex | Pisatrina |
Plurisul | Polibatrin | Politrim | Polytran | Pribac | Primadex | Primasul | Primasulf |
Primatrim | Primavon | Primazol | Primazole | Primotren | Primox | Primsulfon | Primzole |
Protrin | Pulkrin | Purbac | Qiftrim | Qiftrin | Quimio-PED | Quisulyn | Rancotrim |
Rasat | Raseptol | Ratrim | Regtin | Rematrim | Renatrim | Resprim | Retrim |
Rexaprim | Ribatrim | Rimazole | Rimezone | Rivoprim | Rizol | Rolprim | Roubac |
Roxtrim | Roytrin | Salgatran | Saltrim | Sanprima | Saptrim | Satrim | Sbpa Trimeth Smeth |
Scribcin | Seematrim | Seftrim | Selectrin | Semozol | Sepiran | Sepmax | Septabid |
Septazol | Septazole | Septerin | Septinix | Septiolan | Septocid R + | Septoprin | Septra |
Septran | Septrin-S | Septrin Paediatric | Servitrim | Sigaprim | Sigatrim | Silpin | Siltran |
Sinatrim | Sinersul | Sinotrim | Sisoprim | Sistrim | Sitrim | Skytrin | Smartrim |
Soltrim | Soptrim | Sosetran | Spectrem | Spectrim | Stan | Stopan | Strim |
Suftrex | Sulbacta | Sulfagrand | Sulfamer | Sulfamet | Sulfamethoprim | Sulfametoxazol | Sulfaprim |
Sulfarim | Sulfatalpin | Sulfaton | Sulfatrim | Sulfatropim | Sulfawal-T | Sulfinam | Sulfoid Trimetho |
Sulfometh | Sulfonamide | Sulfort | Sulfotrim | Sulfotrimin | Sulftran | Sulgotri | Sulotrim |
Sulphaprim | Sulphathoprim | Sulphatran | Sulphatrim | Sulphax | Sulphytrim Forte | Sulprim | Sulprimed |
Sultase | Sulthrim | Sultiprim | Sultorim | Sultra | Sultrex | Sultrim | Sultrima |
Sultrimmix | Sultrivon-F | Sultropim | Sumetoprim | Sumetrolim | Sumetrolin | Sumitran | Suntrim |
Supim | Supracombin | Suprasulf | Suprex | Supribac | Suprim | Suprimass | Suprin |
Suptrex | Suptrim | Sutaprim | Sutrim | Sutrisan | Suxprim | Syltrifil | Synac |
Synastat | Synbac | Synco-Smzt | Syndal | Synermed | Synerzole | Synetra | Synotrim |
Syntoprim | System | Tabrol | Tagremin | Teof | Terasulf | Terbosulfa | Teutrin |
Theraprim | Therasept | Theratrim | Thoprim | Thriazol | Torrid | Tprim | Trelibec |
Trib | Tricban | Tricomox | Tricot | Trifides | Triforam | Trihexal | Trim |
Trima | Trimaxazole | Trimel | Trimephar | Trimeran | Trimerazin | Trimeril | Trimesol |
Trimesul | Trimesulf | Trimeta | Trimethox | Trimetoger | Trimetop Duplo | Trimetotal | Trimetox |
Trimetrin | Trimetsol | Trimexasol | Trimexazol | Trimexazole | Trimexole-F | Trimezol | Trimezole |
Trimfasul | Trimidar M | Triminex | Trimocom | Trimoks | Trimosul | Trimosulfa | Trimoxavin |
Trimoxazol | Trimoxazole-BC | Trimoxin | Trimoxis | Trimoxsul | Trimozol | Trimsul | Trimzol |
Triphimox | Tripur | Trisep | Trisfides | Trisolak Forte | Trisolvat | Trisul | Trisulcom |
Trisulfa | Trisulfose | Trisuprim | Trisural | Tritenk | Tritosul | Trixazol | Trixzol |
Trizole | Tryseptolum | Tytrim | U-Prin | Ulfaprim | Ultrasept | Ultrazole | Ultrim |
Unitran | Uprina | Urethrax | Urodown | Uroplus DS | Urtium | Utrin | Versatrim |
Virin | Weiditrin | Wiatrim | Wiltran | Wypal | X-Trim | XA-Zole | Xazotrim |
Xepaprim | Xerazole | Xeroprim | Yekaprim | Zactron | Zamboprim | Zantran | Zaxol |
Zecatrim | Zeptra | Zerrprim | Zolebid | Zolmed | Zoltrijem | Zoltrim | Zultrop |