Difference between revisions of "T-cell lymphoma"

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(Created page with "=Extranodal NK/T-cell lymphoma, nasal type= ==SMILE== '''<u>S</u>'''teroid (dexamethasone), '''<u>M</u>'''ethotrexate, '''<u>I</u>'''fosfamide, '''<u>L</u>'''-asparaginase, '...")
 
m (Text replacement - "[[NK/T-cell lymphoma" to "[[NK- and T-cell lymphoma")
 
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=Extranodal NK/T-cell lymphoma, nasal type=
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='''T-cell lymphoma regimens have been moved to their histology-specific subtype pages. Please use the links below and/or update your bookmarks.'''=
  
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==SMILE==
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==[[Anaplastic large cell lymphoma|Anaplastic large cell lymphoma (ALCL)]]==
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'''<u>S</u>'''teroid (dexamethasone), '''<u>M</u>'''ethotrexate, '''<u>I</u>'''fosfamide, '''<u>L</u>'''-asparaginase, '''<u>E</u>'''toposide
 
  
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===Regimen===
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==[[Cutaneous T-cell lymphoma|Cutaneous T-cell lymphoma (CTCL)]]==
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*[[Dexamethasone (Decadron)]] 40 mg PO/IV daily on days 2,3,4
 
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*[[Methotrexate (MTX)]] 2 g/m2 IV once over 6 hours on day 1
 
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*[[Folinic acid (Leucovorin)]] 15 mg PO q6h on days 2,3,4 beginning 24 hours after completion of MTX
 
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*[[Ifosfamide (Ifex)]] 1500 mg/m2 IV once daily on days 2,3,4
 
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*[[Mesna (Mesnex)]] 300 mg/m2 IV q8h on days 2,3,4
 
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*[[Asparaginase (Elspar)]] 6000 units/m2 IV once daily over 2 hours on days 8,10,12,14,16,18,20
 
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*[[Etoposide (Vepesid)]] 100 mg/m2 IV once daily on days 2,3,4
 
  
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Supportive Medications
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==[[Extranodal NK- and T-cell lymphoma, nasal type]]==
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*[[Filgrastim (Neupogen)]] SC/IV daily from day 6 until WBC > 5 x 10^9/L
 
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*[[Trimethoprim/Sulfamethoxazole (Bactrim DS)]] recommended
 
  
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'''28-day cycles for 2 cycles'''
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==[[NK- and T-cell lymphoma]]==
  
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===References===
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==[[Peripheral T-cell lymphoma|Peripheral T-cell Lymphoma (PTCL)]]==
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# Yamaguchi M, Suzuki R, Kwong YL, Kim WS, Hasegawa Y, Izutsu K, Suzumiya J, Okamura T, Nakamura S, Kawa K, Oshimi K. Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia. Cancer Sci. 2008 May;99(5):1016-20. doi:10.1111/j.1349-7006.2008.00768.x. Epub 2008 Feb 19. [http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2008.00768.x/full link to article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/18294294 PubMed]
 
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# Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R. Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol. 2011 Nov 20;29(33):4410-6. doi: 10.1200/JCO.2011.35.6287. Epub 2011 Oct 11. [http://jco.ascopubs.org/content/29/33/4410.long link to article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/21990393 PubMed]
 
  
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=NK/T-cell lymphoma=
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[[Category:Obsolete pages]]
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==SMILE==
 
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'''<u>S</u>'''teroid (dexamethasone), '''<u>M</u>'''ethotrexate, '''<u>I</u>'''fosfamide, '''<u>L</u>'''-asparaginase, '''<u>E</u>'''toposide
 
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===Regimen===
 
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*[[Dexamethasone (Decadron)]] 40 mg PO daily on days 2,3,4
 
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*[[Methotrexate (MTX)]] 2 g/m2 IV once over 6 hours on day 1
 
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*[[Folinic acid (Leucovorin)]] 45 mg PO q6h on days 2,3,4 beginning 24 hours after completion of MTX
 
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*[[Ifosfamide (Ifex)]] 1500 mg/m2 IV once daily (admix with mesna) over 6 hours on days 2,3,4
 
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*[[Mesna (Mesnex)]] 900 mg/m2 IV once daily (admix with ifosfamide) over 6 hours on days 2,3,4
 
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*[[Asparaginase (Elspar)]] 6000 units/m2 IV once daily over 2 hours on days 8,10,12,14,16,18,20
 
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*[[Etoposide (Vepesid)]] 100 mg/m2 IV once daily over 2 hours on days 2,3,4
 
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Supportive Medications
 
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*[[Filgrastim (Neupogen)]] 300 mcg SC daily from day 6 until ANC > 1 x 10^9/L
 
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*[[Cotrimoxazole]] or [[Pentamidine (Nebupent)]] for PJP prophylaxis
 
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'''28-day cycles up to 6 cycles'''
 
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===References===
 
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#  Kwong YL, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, Leung AY, Chim CS. SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group. Blood. 2012 Oct 11;120(15):2973-80. doi:10.1182/blood-2012-05-431460. Epub 2012 Aug 23. [http://bloodjournal.hematologylibrary.org/content/120/15/2973.long link to article] '''verified protocol in supplement''' [http://www.ncbi.nlm.nih.gov/pubmed/22919026 PubMed]
 

Latest revision as of 16:50, 23 November 2019

T-cell lymphoma regimens have been moved to their histology-specific subtype pages. Please use the links below and/or update your bookmarks.

Anaplastic large cell lymphoma (ALCL)

Cutaneous T-cell lymphoma (CTCL)

Extranodal NK- and T-cell lymphoma, nasal type

NK- and T-cell lymphoma

Peripheral T-cell Lymphoma (PTCL)

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