Difference between revisions of "Warfarin (Coumadin)"

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search
(Created page with "Also known as Apo-Warfarin, Jantoven, Mylan-Warfarin, Novo-Warfarin, or Taro-Warfarin. ==General information== Class/mechanism: Vitamin K antagonist, inhibits the production of ...")
 
m (Text replacement - "[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or" to "or")
 
(22 intermediate revisions by 4 users not shown)
Line 1: Line 1:
−
Also known as Apo-Warfarin, Jantoven, Mylan-Warfarin, Novo-Warfarin, or Taro-Warfarin.
 
−
 
 
==General information==
 
==General information==
−
Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S.  Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1).  Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.<ref name="insert">[http://packageinserts.bms.com/pi/pi_coumadin.pdf Warfarin (Coumadin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/warfarin.pdf Warfarin (Coumadin) package insert (locally hosted backup)]</ref>
+
Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S.  Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1).  Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.<ref name="insert">[http://packageinserts.bms.com/pi/pi_coumadin.pdf Warfarin (Coumadin) package insert]</ref><ref>[[:File:Warfarin.pdf | Warfarin (Coumadin) package insert (locally hosted backup)]]</ref><ref>[http://www.coumadin.com Coumadin manufacturer's website]</ref>
 
<br>Route: PO
 
<br>Route: PO
 
<br>Extravasation: n/a
 
<br>Extravasation: n/a
  
−
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information<ref name="insert"></ref>.
+
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.<ref name="insert"></ref>
  
 
==Patient drug information==
 
==Patient drug information==
−
*[http://packageinserts.bms.com/pi/pi_coumadin.pdf#page=8 Warfarin (Coumadin) package insert PDF pages 8-10]<ref name="insert"></ref>
+
*[http://packageinserts.bms.com/pi/pi_coumadin.pdf Warfarin (Coumadin) package insert]<ref name="insert"></ref>
 
*[http://www.uptodate.com/contents/warfarin-patient-drug-information Warfarin (Coumadin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/warfarin-patient-drug-information Warfarin (Coumadin) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/warfarin-patient-drug-information Warfarin (Coumadin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/warfarin-patient-drug-information Warfarin (Coumadin) patient drug information (UpToDate)]</ref>
 +
 +
==Diseases for which it is used==
 +
*[[Antiphospholipid antibody syndrome]]
 +
*[[Venous thromboembolism]]
 +
 +
==Also known as==
 +
*'''Generic name:''' warfarina sodica
 +
*'''Brand names:'''
 +
{| class="wikitable" style="text-align:center;"
 +
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 +
|-
 +
|Aldocumar
 +
|Anasmol
 +
|Anticoag
 +
|Arefarin
 +
|Athrombin-K
 +
|Befarin
 +
|Caumadin
 +
|Cicoxil
 +
|-
 +
|Circuvit
 +
|Coumadin
 +
|Coumadine
 +
|Couparin
 +
|Dagonal
 +
|Farin
 +
|Ferevan
 +
|Fericard
 +
|-
 +
|Haemofarin
 +
|Jantoven
 +
|Kovar
 +
|Lawarin
 +
|Maforan
 +
|Marfarin
 +
|Marivanil
 +
|Marivarin
 +
|-
 +
|Orfarin
 +
|Panwarfin
 +
|Panwarfine
 +
|Romesa
 +
|Samofaron
 +
|Simarc
 +
|Tedicumar
 +
|Varfarins
 +
|-
 +
|Varfine
 +
|Waran
 +
|Warf
 +
|Warfa
 +
|Warfant
 +
|Warfar
 +
|Warfarex
 +
|Warfil
 +
|-
 +
|Warfilone
 +
|Warfin
 +
|Warin
 +
|Warlin
 +
|Warnerin
 +
|Werifrin
 +
|-
 +
|}
  
 
==References==
 
==References==
 
<references/>
 
<references/>
 +
 +
[[Category:Drugs]]
 +
[[Category:Oral medications]]
 +
 +
[[Category:Anticoagulants]]
 +
[[Category:Vitamin K antagonists]]
 +
 +
[[Category:Antiphospholipid antibody syndrome medications]]
 +
[[Category:Venous thromboembolism medications]]
 +
 +
[[Category:FDA approved in 1954]]

Latest revision as of 00:06, 6 July 2024

General information

Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information.[1]

Patient drug information

Diseases for which it is used

Also known as

  • Generic name: warfarina sodica
  • Brand names:
Synonyms
Aldocumar Anasmol Anticoag Arefarin Athrombin-K Befarin Caumadin Cicoxil
Circuvit Coumadin Coumadine Couparin Dagonal Farin Ferevan Fericard
Haemofarin Jantoven Kovar Lawarin Maforan Marfarin Marivanil Marivarin
Orfarin Panwarfin Panwarfine Romesa Samofaron Simarc Tedicumar Varfarins
Varfine Waran Warf Warfa Warfant Warfar Warfarex Warfil
Warfilone Warfin Warin Warlin Warnerin Werifrin

References

  1. ↑ 1.0 1.1 1.2 Warfarin (Coumadin) package insert
  2. ↑ Warfarin (Coumadin) package insert (locally hosted backup)
  3. ↑ Coumadin manufacturer's website
  4. ↑ Warfarin (Coumadin) patient drug information (UpToDate)
Retrieved from "https://hemonc.org/w/index.php?title=Warfarin_(Coumadin)&oldid=88335"