Difference between revisions of "Trimethoprim-Sulfamethoxazole (Bactrim DS)"
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==General information== | ==General information== | ||
− | Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/17377slr057_Bactrim_lbl.pdf Trimethoprim | + | Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/17377slr057_Bactrim_lbl.pdf Trimethoprim-Sulfamethoxazole (Bactrim DS) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/trimethoprimsulfamethoxazole.pdf Trimethoprim-Sulfamethoxazole (Bactrim DS) package insert (locally hosted backup)]</ref> |
<br>Route: PO, IV | <br>Route: PO, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
− | *[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim | + | *[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/trimethoprim-sulfamethoxazole-co-trimoxazole-patient-drug-information Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)]</ref> |
+ | |||
+ | ==Also known as== | ||
+ | *'''Generic names:''' cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS | ||
+ | *'''Brand names:''' | ||
+ | {| class="wikitable" style="text-align:center;" | ||
+ | !colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms''' | ||
+ | |- | ||
+ | |Abacin | ||
+ | |Abactrim | ||
+ | |Abatrim | ||
+ | |Abditri | ||
+ | |Abetrim | ||
+ | |Actrim | ||
+ | |Aditrim | ||
+ | |Adrenol | ||
+ | |- | ||
+ | |Adtrim | ||
+ | |Aksotran | ||
+ | |Albrotran | ||
+ | |Albutrim | ||
+ | |Alcorim-F | ||
+ | |Alcot | ||
+ | |Allibac | ||
+ | |Altrim | ||
+ | |- | ||
+ | |Amazole | ||
+ | |Amoxazol | ||
+ | |Amtran | ||
+ | |Amtril | ||
+ | |Andoprim | ||
+ | |Anitrim | ||
+ | |Anprim | ||
+ | |Antibac | ||
+ | |- | ||
+ | |Antrim | ||
+ | |Antrimox | ||
+ | |Apcetrim | ||
+ | |APO-Bactotrim | ||
+ | |APO Sulfatrim | ||
+ | |Apotrinelax | ||
+ | |Aptrim | ||
+ | |Aratran | ||
+ | |- | ||
+ | |Ascotran | ||
+ | |Aspen | ||
+ | |Assepium | ||
+ | |Atomexin | ||
+ | |Avlotrin | ||
+ | |B.S. | ||
+ | |BAC-Sulfitrin | ||
+ | |Bacfar | ||
+ | |- | ||
+ | |Bacidal | ||
+ | |Bacin | ||
+ | |Bacitran | ||
+ | |Bacmetrin | ||
+ | |Bacoprim | ||
+ | |Bacotrin | ||
+ | |Bacprotin | ||
+ | |Bacris | ||
+ | |- | ||
+ | |Bacsulfaprin | ||
+ | |Bacsultrim | ||
+ | |Bactar | ||
+ | |Bactazol | ||
+ | |Bactekod | ||
+ | |Bactelan | ||
+ | |Bacteracin | ||
+ | |Bacterial | ||
+ | |- | ||
+ | |Bacteric | ||
+ | |Bacteriof.klebs PN | ||
+ | |Bacterol | ||
+ | |Bacticel | ||
+ | |Bactide | ||
+ | |Bactifor | ||
+ | |Bactigram | ||
+ | |Bactille-TS | ||
+ | |- | ||
+ | |Bactipront | ||
+ | |Bactiseptol | ||
+ | |Bactiver | ||
+ | |Bactoprim | ||
+ | |Bactoreduct | ||
+ | |Bactosain | ||
+ | |Bactostab | ||
+ | |Bactramin | ||
+ | |- | ||
+ | |Bactricid | ||
+ | |Bactricida | ||
+ | |Bactricin | ||
+ | |Bactrilac | ||
+ | |Bactrim | ||
+ | |Bactrimel | ||
+ | |Bactrin | ||
+ | |Bactrisan | ||
+ | |- | ||
+ | |Bactrium DS | ||
+ | |Bactrizole | ||
+ | |Bactron | ||
+ | |Bactronil | ||
+ | |Bactropin | ||
+ | |Bacxal | ||
+ | |Baczin | ||
+ | |Baczole | ||
+ | |- | ||
+ | |Baklinger | ||
+ | |Baktar | ||
+ | |Bakton | ||
+ | |Baktrisid DS | ||
+ | |Balkatrin | ||
+ | |Balkatrine | ||
+ | |Bantizol | ||
+ | |Basatin | ||
+ | |- | ||
+ | |Baserin | ||
+ | |Batrox | ||
+ | |Baxolex | ||
+ | |Belfactrin | ||
+ | |Bencole | ||
+ | |Benectrin | ||
+ | |Berlocid | ||
+ | |Bestofens | ||
+ | |- | ||
+ | |Bethaprim | ||
+ | |Bibakrim | ||
+ | |Bicotrim | ||
+ | |Bimatrim | ||
+ | |Bioprim | ||
+ | |Biosulten | ||
+ | |Biotran | ||
+ | |Biotrim | ||
+ | |- | ||
+ | |Biotrin | ||
+ | |Biprim | ||
+ | |Biseptin | ||
+ | |Biseptol | ||
+ | |Biseptrim | ||
+ | |Bismoral | ||
+ | |Bisultrim | ||
+ | |Bitrim | ||
+ | |- | ||
+ | |Blexon | ||
+ | |Boschtrim | ||
+ | |Brifeseptol | ||
+ | |Broncoflam | ||
+ | |Brongenit | ||
+ | |BS | ||
+ | |Canprim | ||
+ | |Caretran | ||
+ | |- | ||
+ | |Centrim | ||
+ | |Chemitrim | ||
+ | |Chemix | ||
+ | |Chemizol | ||
+ | |Chemoprim | ||
+ | |Chemotran | ||
+ | |Chemotrim | ||
+ | |Chemotrin | ||
+ | |- | ||
+ | |Chemozole | ||
+ | |Chromo-Z | ||
+ | |Cidaprim | ||
+ | |Cipaprim | ||
+ | |Ciplin | ||
+ | |Citrim | ||
+ | |Cladon | ||
+ | |Clinitran | ||
+ | |- | ||
+ | |Clonea | ||
+ | |Clotrizol | ||
+ | |CO-Sultrin | ||
+ | |CO-Tasian | ||
+ | |CO-Traisole 480 | ||
+ | |CO-Trim-Tablinen | ||
+ | |CO-Trimazole | ||
+ | |CO-Trimed | ||
+ | |- | ||
+ | |CO-Trimoxa | ||
+ | |CO-Trimoxazol | ||
+ | |Cobact | ||
+ | |Cobal ST | ||
+ | |Cocydal | ||
+ | |Cofatrim | ||
+ | |Colitran | ||
+ | |Colizole | ||
+ | |- | ||
+ | |Colotrim | ||
+ | |Comax | ||
+ | |Comazole | ||
+ | |Combact | ||
+ | |Combi-Methoxan | ||
+ | |Comixco | ||
+ | |Comox | ||
+ | |Comoxol | ||
+ | |- | ||
+ | |Contrimoxazole | ||
+ | |Coprim | ||
+ | |Coprime | ||
+ | |Cosat | ||
+ | |Cosig | ||
+ | |Costazole | ||
+ | |Cosulf | ||
+ | |Cotoram | ||
+ | |- | ||
+ | |Cotran | ||
+ | |Cotrazen | ||
+ | |Cotrexel | ||
+ | |Cotri | ||
+ | |Cotribase | ||
+ | |Cotribene | ||
+ | |Cotribid | ||
+ | |Cotril | ||
+ | |- | ||
+ | |Cotrilin | ||
+ | |Cotrim | ||
+ | |Cotrimax | ||
+ | |Cotrimaxazol | ||
+ | |Cotrimaxazole | ||
+ | |Cotrimel | ||
+ | |Cotrimhexal | ||
+ | |Cotrimol | ||
+ | |- | ||
+ | |Cotrimox | ||
+ | |Cotrimoxazol | ||
+ | |Cotrimoxin | ||
+ | |Cotrimstada | ||
+ | |Cotripharm | ||
+ | |Cotrisul | ||
+ | |Cotrixyl-L | ||
+ | |Cotrizol | ||
+ | |- | ||
+ | |Cotrizole | ||
+ | |Cots | ||
+ | |Cozol | ||
+ | |Cozole | ||
+ | |Creptrim | ||
+ | |Curaprim | ||
+ | |Daiphen | ||
+ | |Decatrim | ||
+ | |- | ||
+ | |Deotrim | ||
+ | |Dertrin | ||
+ | |Dhatrin | ||
+ | |Dino-BAC | ||
+ | |Diseptyl | ||
+ | |Doctrim | ||
+ | |Dosatran | ||
+ | |Drilozole | ||
+ | |- | ||
+ | |Drossul | ||
+ | |Droxol | ||
+ | |Drylin | ||
+ | |Dubac | ||
+ | |Dumotrim | ||
+ | |Duobact | ||
+ | |Duobiocin | ||
+ | |Duoctrin | ||
+ | |- | ||
+ | |DUO Septol | ||
+ | |Duratrimet | ||
+ | |Dutran | ||
+ | |Dvaseptol | ||
+ | |Dynaprim | ||
+ | |Ectaprim | ||
+ | |Ectrin | ||
+ | |Editrim | ||
+ | |- | ||
+ | |Eduprim | ||
+ | |Eliprim | ||
+ | |Eroprim | ||
+ | |Erotrim | ||
+ | |Erphatrim | ||
+ | |Esbesul | ||
+ | |Escoprim | ||
+ | |Espectrin | ||
+ | |- | ||
+ | |Espectroprima | ||
+ | |Ethitrim | ||
+ | |Eurotrim | ||
+ | |Eusaprim | ||
+ | |Eutrim | ||
+ | |Exazol | ||
+ | |Fabubac | ||
+ | |Fakzol | ||
+ | |- | ||
+ | |Falprim | ||
+ | |Fameprim | ||
+ | |Fectrim | ||
+ | |Fedimed | ||
+ | |Fisat | ||
+ | |Flatran | ||
+ | |Flocot | ||
+ | |Forcrim | ||
+ | |- | ||
+ | |Forteprim | ||
+ | |Gamactrin | ||
+ | |Gatrima | ||
+ | |Genoctrin | ||
+ | |Genoxzole | ||
+ | |Gentrim | ||
+ | |Genzaprim | ||
+ | |Getrim | ||
+ | |- | ||
+ | |Globaxol | ||
+ | |Gobens Trim | ||
+ | |Graprima | ||
+ | |Groseptol | ||
+ | |Gunametrim | ||
+ | |Hatrix | ||
+ | |Helveprim | ||
+ | |Herixina | ||
+ | |- | ||
+ | |Hexaprim | ||
+ | |Hicot | ||
+ | |Hufacid | ||
+ | |Huma-Trimel | ||
+ | |Ibtrim | ||
+ | |Imcotran | ||
+ | |Imexim | ||
+ | |Inatrim | ||
+ | |- | ||
+ | |Infatrim | ||
+ | |Infectran | ||
+ | |Infectrim | ||
+ | |Infectrin | ||
+ | |Infesin | ||
+ | |Intrafort | ||
+ | |Introcin | ||
+ | |Irgagen | ||
+ | |- | ||
+ | |Isoprim | ||
+ | |Isotrim | ||
+ | |Japtrim | ||
+ | |Jasotrim | ||
+ | |Jenamoxazol | ||
+ | |Jestrim | ||
+ | |Justeprim | ||
+ | |K.B.famate | ||
+ | |- | ||
+ | |Kaftrim | ||
+ | |Kathrex | ||
+ | |Katrim | ||
+ | |Kaytran | ||
+ | |Kemocid | ||
+ | |Kemoprim | ||
+ | |Kentricid | ||
+ | |Kepinol | ||
+ | |- | ||
+ | |Kindoprim | ||
+ | |KO-Kure | ||
+ | |Kombina | ||
+ | |Kotazol | ||
+ | |Kotrimoksazol | ||
+ | |Krobactrol | ||
+ | |L-Trim | ||
+ | |Lacreozole | ||
+ | |- | ||
+ | |Lagatrim | ||
+ | |Lapikot | ||
+ | |Laratrim | ||
+ | |Larprim | ||
+ | |Lastrim | ||
+ | |Leotrim | ||
+ | |Leprim | ||
+ | |Lescot | ||
+ | |- | ||
+ | |Letus | ||
+ | |Lictora | ||
+ | |Lifactrin | ||
+ | |Lifzol | ||
+ | |Lisaprin | ||
+ | |Litrim | ||
+ | |Lobact | ||
+ | |Longasal | ||
+ | |- | ||
+ | |Lupectrin | ||
+ | |Lusaprim | ||
+ | |Lykaprim | ||
+ | |M-Moxa | ||
+ | |M-Trim | ||
+ | |Macprim | ||
+ | |Macromed | ||
+ | |Mactran | ||
+ | |- | ||
+ | |Madroxin | ||
+ | |Maktrim | ||
+ | |Martiprim | ||
+ | |Maxaprim | ||
+ | |Maxiprim | ||
+ | |Maxitrin | ||
+ | |Maxol | ||
+ | |Maxtrim | ||
+ | |- | ||
+ | |Maxzol | ||
+ | |Mazatrim | ||
+ | |Mebryn | ||
+ | |Medcotrim | ||
+ | |Mediprim | ||
+ | |Meditran | ||
+ | |Meditrim | ||
+ | |Medtrim | ||
+ | |- | ||
+ | |Megabroncoflam | ||
+ | |Megaset | ||
+ | |Megatrim | ||
+ | |Meprim | ||
+ | |Meprotrin | ||
+ | |Methoprim | ||
+ | |Methotrin | ||
+ | |Metoprim | ||
+ | |- | ||
+ | |Metoprin | ||
+ | |Metoxiprim | ||
+ | |Metrim | ||
+ | |Metxaprim | ||
+ | |Mexaprim | ||
+ | |Mexazole | ||
+ | |Mezenol | ||
+ | |Micinovo | ||
+ | |- | ||
+ | |Micogyl | ||
+ | |Microbid | ||
+ | |Microcetim | ||
+ | |Microdyn | ||
+ | |Microsupos Amigdalar | ||
+ | |Microtrim | ||
+ | |Mikotrim | ||
+ | |Mikrosid | ||
+ | |- | ||
+ | |Miratrim | ||
+ | |Moly | ||
+ | |Mortin | ||
+ | |Moxadden | ||
+ | |Moxalas | ||
+ | |Moxatrim | ||
+ | |Moxzole | ||
+ | |Mukadryl | ||
+ | |- | ||
+ | |Myctrim | ||
+ | |Naftran | ||
+ | |Napatrim | ||
+ | |Navatrim | ||
+ | |Necorzole | ||
+ | |Neoset | ||
+ | |Neotrim | ||
+ | |Netocur | ||
+ | |- | ||
+ | |Neuroprim | ||
+ | |Nicotrim | ||
+ | |Nilium | ||
+ | |Nodilon | ||
+ | |Nopil | ||
+ | |Norisep | ||
+ | |Nortrim | ||
+ | |Nortrime | ||
+ | |- | ||
+ | |Notrim | ||
+ | |Notrime | ||
+ | |Novactil | ||
+ | |Novidrine | ||
+ | |Novotrimel | ||
+ | |Novotrimox | ||
+ | |Novotrim Plus | ||
+ | |Novozole | ||
+ | |- | ||
+ | |Nucotrim | ||
+ | |Nufaprim | ||
+ | |Nuruzole | ||
+ | |Octil-S | ||
+ | |Octran | ||
+ | |Octrim | ||
+ | |Oecotrim | ||
+ | |Okatrim | ||
+ | |- | ||
+ | |Omegtrim | ||
+ | |Omnatrim | ||
+ | |Omsat | ||
+ | |Onetrim | ||
+ | |Oradin | ||
+ | |Orbak | ||
+ | |Orgastran | ||
+ | |Oribact | ||
+ | |- | ||
+ | |Ormoprim | ||
+ | |Ostrin Forte | ||
+ | |Otrim | ||
+ | |Ottoprim | ||
+ | |Oxaprim | ||
+ | |Pakzole | ||
+ | |Pantrim | ||
+ | |Patrim | ||
+ | |- | ||
+ | |Pehatrim | ||
+ | |Penetrin | ||
+ | |Pentrin | ||
+ | |Penzole | ||
+ | |Pharmatrim | ||
+ | |Pharmazol | ||
+ | |Phartex | ||
+ | |Pisatrina | ||
+ | |- | ||
+ | |Plurisul | ||
+ | |Polibatrin | ||
+ | |Politrim | ||
+ | |Polytran | ||
+ | |Pribac | ||
+ | |Primadex | ||
+ | |Primasul | ||
+ | |Primasulf | ||
+ | |- | ||
+ | |Primatrim | ||
+ | |Primavon | ||
+ | |Primazol | ||
+ | |Primazole | ||
+ | |Primotren | ||
+ | |Primox | ||
+ | |Primsulfon | ||
+ | |Primzole | ||
+ | |- | ||
+ | |Protrin | ||
+ | |Pulkrin | ||
+ | |Purbac | ||
+ | |Qiftrim | ||
+ | |Qiftrin | ||
+ | |Quimio-PED | ||
+ | |Quisulyn | ||
+ | |Rancotrim | ||
+ | |- | ||
+ | |Rasat | ||
+ | |Raseptol | ||
+ | |Ratrim | ||
+ | |Regtin | ||
+ | |Rematrim | ||
+ | |Renatrim | ||
+ | |Resprim | ||
+ | |Retrim | ||
+ | |- | ||
+ | |Rexaprim | ||
+ | |Ribatrim | ||
+ | |Rimazole | ||
+ | |Rimezone | ||
+ | |Rivoprim | ||
+ | |Rizol | ||
+ | |Rolprim | ||
+ | |Roubac | ||
+ | |- | ||
+ | |Roxtrim | ||
+ | |Roytrin | ||
+ | |Salgatran | ||
+ | |Saltrim | ||
+ | |Sanprima | ||
+ | |Saptrim | ||
+ | |Satrim | ||
+ | |Sbpa Trimeth Smeth | ||
+ | |- | ||
+ | |Scribcin | ||
+ | |Seematrim | ||
+ | |Seftrim | ||
+ | |Selectrin | ||
+ | |Semozol | ||
+ | |Sepiran | ||
+ | |Sepmax | ||
+ | |Septabid | ||
+ | |- | ||
+ | |Septazol | ||
+ | |Septazole | ||
+ | |Septerin | ||
+ | |Septinix | ||
+ | |Septiolan | ||
+ | |Septocid R + | ||
+ | |Septoprin | ||
+ | |Septra | ||
+ | |- | ||
+ | |Septran | ||
+ | |Septrin-S | ||
+ | |Septrin Paediatric | ||
+ | |Servitrim | ||
+ | |Sigaprim | ||
+ | |Sigatrim | ||
+ | |Silpin | ||
+ | |Siltran | ||
+ | |- | ||
+ | |Sinatrim | ||
+ | |Sinersul | ||
+ | |Sinotrim | ||
+ | |Sisoprim | ||
+ | |Sistrim | ||
+ | |Sitrim | ||
+ | |Skytrin | ||
+ | |Smartrim | ||
+ | |- | ||
+ | |Soltrim | ||
+ | |Soptrim | ||
+ | |Sosetran | ||
+ | |Spectrem | ||
+ | |Spectrim | ||
+ | |Stan | ||
+ | |Stopan | ||
+ | |Strim | ||
+ | |- | ||
+ | |Suftrex | ||
+ | |Sulbacta | ||
+ | |Sulfagrand | ||
+ | |Sulfamer | ||
+ | |Sulfamet | ||
+ | |Sulfamethoprim | ||
+ | |Sulfametoxazol | ||
+ | |Sulfaprim | ||
+ | |- | ||
+ | |Sulfarim | ||
+ | |Sulfatalpin | ||
+ | |Sulfaton | ||
+ | |Sulfatrim | ||
+ | |Sulfatropim | ||
+ | |Sulfawal-T | ||
+ | |Sulfinam | ||
+ | |Sulfoid Trimetho | ||
+ | |- | ||
+ | |Sulfometh | ||
+ | |Sulfonamide | ||
+ | |Sulfort | ||
+ | |Sulfotrim | ||
+ | |Sulfotrimin | ||
+ | |Sulftran | ||
+ | |Sulgotri | ||
+ | |Sulotrim | ||
+ | |- | ||
+ | |Sulphaprim | ||
+ | |Sulphathoprim | ||
+ | |Sulphatran | ||
+ | |Sulphatrim | ||
+ | |Sulphax | ||
+ | |Sulphytrim Forte | ||
+ | |Sulprim | ||
+ | |Sulprimed | ||
+ | |- | ||
+ | |Sultase | ||
+ | |Sulthrim | ||
+ | |Sultiprim | ||
+ | |Sultorim | ||
+ | |Sultra | ||
+ | |Sultrex | ||
+ | |Sultrim | ||
+ | |Sultrima | ||
+ | |- | ||
+ | |Sultrimmix | ||
+ | |Sultrivon-F | ||
+ | |Sultropim | ||
+ | |Sumetoprim | ||
+ | |Sumetrolim | ||
+ | |Sumetrolin | ||
+ | |Sumitran | ||
+ | |Suntrim | ||
+ | |- | ||
+ | |Supim | ||
+ | |Supracombin | ||
+ | |Suprasulf | ||
+ | |Suprex | ||
+ | |Supribac | ||
+ | |Suprim | ||
+ | |Suprimass | ||
+ | |Suprin | ||
+ | |- | ||
+ | |Suptrex | ||
+ | |Suptrim | ||
+ | |Sutaprim | ||
+ | |Sutrim | ||
+ | |Sutrisan | ||
+ | |Suxprim | ||
+ | |Syltrifil | ||
+ | |Synac | ||
+ | |- | ||
+ | |Synastat | ||
+ | |Synbac | ||
+ | |Synco-Smzt | ||
+ | |Syndal | ||
+ | |Synermed | ||
+ | |Synerzole | ||
+ | |Synetra | ||
+ | |Synotrim | ||
+ | |- | ||
+ | |Syntoprim | ||
+ | |System | ||
+ | |Tabrol | ||
+ | |Tagremin | ||
+ | |Teof | ||
+ | |Terasulf | ||
+ | |Terbosulfa | ||
+ | |Teutrin | ||
+ | |- | ||
+ | |Theraprim | ||
+ | |Therasept | ||
+ | |Theratrim | ||
+ | |Thoprim | ||
+ | |Thriazol | ||
+ | |Torrid | ||
+ | |Tprim | ||
+ | |Trelibec | ||
+ | |- | ||
+ | |Trib | ||
+ | |Tricban | ||
+ | |Tricomox | ||
+ | |Tricot | ||
+ | |Trifides | ||
+ | |Triforam | ||
+ | |Trihexal | ||
+ | |Trim | ||
+ | |- | ||
+ | |Trima | ||
+ | |Trimaxazole | ||
+ | |Trimel | ||
+ | |Trimephar | ||
+ | |Trimeran | ||
+ | |Trimerazin | ||
+ | |Trimeril | ||
+ | |Trimesol | ||
+ | |- | ||
+ | |Trimesul | ||
+ | |Trimesulf | ||
+ | |Trimeta | ||
+ | |Trimethox | ||
+ | |Trimetoger | ||
+ | |Trimetop Duplo | ||
+ | |Trimetotal | ||
+ | |Trimetox | ||
+ | |- | ||
+ | |Trimetrin | ||
+ | |Trimetsol | ||
+ | |Trimexasol | ||
+ | |Trimexazol | ||
+ | |Trimexazole | ||
+ | |Trimexole-F | ||
+ | |Trimezol | ||
+ | |Trimezole | ||
+ | |- | ||
+ | |Trimfasul | ||
+ | |Trimidar M | ||
+ | |Triminex | ||
+ | |Trimocom | ||
+ | |Trimoks | ||
+ | |Trimosul | ||
+ | |Trimosulfa | ||
+ | |Trimoxavin | ||
+ | |- | ||
+ | |Trimoxazol | ||
+ | |Trimoxazole-BC | ||
+ | |Trimoxin | ||
+ | |Trimoxis | ||
+ | |Trimoxsul | ||
+ | |Trimozol | ||
+ | |Trimsul | ||
+ | |Trimzol | ||
+ | |- | ||
+ | |Triphimox | ||
+ | |Tripur | ||
+ | |Trisep | ||
+ | |Trisfides | ||
+ | |Trisolak Forte | ||
+ | |Trisolvat | ||
+ | |Trisul | ||
+ | |Trisulcom | ||
+ | |- | ||
+ | |Trisulfa | ||
+ | |Trisulfose | ||
+ | |Trisuprim | ||
+ | |Trisural | ||
+ | |Tritenk | ||
+ | |Tritosul | ||
+ | |Trixazol | ||
+ | |Trixzol | ||
+ | |- | ||
+ | |Trizole | ||
+ | |Tryseptolum | ||
+ | |Tytrim | ||
+ | |U-Prin | ||
+ | |Ulfaprim | ||
+ | |Ultrasept | ||
+ | |Ultrazole | ||
+ | |Ultrim | ||
+ | |- | ||
+ | |Unitran | ||
+ | |Uprina | ||
+ | |Urethrax | ||
+ | |Urodown | ||
+ | |Uroplus DS | ||
+ | |Urtium | ||
+ | |Utrin | ||
+ | |Versatrim | ||
+ | |- | ||
+ | |Virin | ||
+ | |Weiditrin | ||
+ | |Wiatrim | ||
+ | |Wiltran | ||
+ | |Wypal | ||
+ | |X-Trim | ||
+ | |XA-Zole | ||
+ | |Xazotrim | ||
+ | |- | ||
+ | |Xepaprim | ||
+ | |Xerazole | ||
+ | |Xeroprim | ||
+ | |Yekaprim | ||
+ | |Zactron | ||
+ | |Zamboprim | ||
+ | |Zantran | ||
+ | |Zaxol | ||
+ | |- | ||
+ | |Zecatrim | ||
+ | |Zeptra | ||
+ | |Zerrprim | ||
+ | |Zolebid | ||
+ | |Zolmed | ||
+ | |Zoltrijem | ||
+ | |Zoltrim | ||
+ | |Zultrop | ||
+ | |- | ||
+ | |} | ||
==References== | ==References== | ||
<references/> | <references/> | ||
+ | |||
+ | [[Category:Drugs]] | ||
+ | [[Category:Combination drugs]] | ||
+ | [[Category:Oral medications]] | ||
+ | [[Category:Intravenous medications]] | ||
+ | |||
+ | [[Category:Antimetabolites]] | ||
+ | [[Category:Antifolates]] | ||
+ | |||
+ | [[Category:Antibacterials]] | ||
+ | [[Category:PCP prophylaxis]] | ||
+ | |||
+ | [[Category:FDA approved in 1973]] |
Latest revision as of 12:11, 29 June 2024
General information
Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.[1][2]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
Also known as
- Generic names: cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS
- Brand names:
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Abacin | Abactrim | Abatrim | Abditri | Abetrim | Actrim | Aditrim | Adrenol |
Adtrim | Aksotran | Albrotran | Albutrim | Alcorim-F | Alcot | Allibac | Altrim |
Amazole | Amoxazol | Amtran | Amtril | Andoprim | Anitrim | Anprim | Antibac |
Antrim | Antrimox | Apcetrim | APO-Bactotrim | APO Sulfatrim | Apotrinelax | Aptrim | Aratran |
Ascotran | Aspen | Assepium | Atomexin | Avlotrin | B.S. | BAC-Sulfitrin | Bacfar |
Bacidal | Bacin | Bacitran | Bacmetrin | Bacoprim | Bacotrin | Bacprotin | Bacris |
Bacsulfaprin | Bacsultrim | Bactar | Bactazol | Bactekod | Bactelan | Bacteracin | Bacterial |
Bacteric | Bacteriof.klebs PN | Bacterol | Bacticel | Bactide | Bactifor | Bactigram | Bactille-TS |
Bactipront | Bactiseptol | Bactiver | Bactoprim | Bactoreduct | Bactosain | Bactostab | Bactramin |
Bactricid | Bactricida | Bactricin | Bactrilac | Bactrim | Bactrimel | Bactrin | Bactrisan |
Bactrium DS | Bactrizole | Bactron | Bactronil | Bactropin | Bacxal | Baczin | Baczole |
Baklinger | Baktar | Bakton | Baktrisid DS | Balkatrin | Balkatrine | Bantizol | Basatin |
Baserin | Batrox | Baxolex | Belfactrin | Bencole | Benectrin | Berlocid | Bestofens |
Bethaprim | Bibakrim | Bicotrim | Bimatrim | Bioprim | Biosulten | Biotran | Biotrim |
Biotrin | Biprim | Biseptin | Biseptol | Biseptrim | Bismoral | Bisultrim | Bitrim |
Blexon | Boschtrim | Brifeseptol | Broncoflam | Brongenit | BS | Canprim | Caretran |
Centrim | Chemitrim | Chemix | Chemizol | Chemoprim | Chemotran | Chemotrim | Chemotrin |
Chemozole | Chromo-Z | Cidaprim | Cipaprim | Ciplin | Citrim | Cladon | Clinitran |
Clonea | Clotrizol | CO-Sultrin | CO-Tasian | CO-Traisole 480 | CO-Trim-Tablinen | CO-Trimazole | CO-Trimed |
CO-Trimoxa | CO-Trimoxazol | Cobact | Cobal ST | Cocydal | Cofatrim | Colitran | Colizole |
Colotrim | Comax | Comazole | Combact | Combi-Methoxan | Comixco | Comox | Comoxol |
Contrimoxazole | Coprim | Coprime | Cosat | Cosig | Costazole | Cosulf | Cotoram |
Cotran | Cotrazen | Cotrexel | Cotri | Cotribase | Cotribene | Cotribid | Cotril |
Cotrilin | Cotrim | Cotrimax | Cotrimaxazol | Cotrimaxazole | Cotrimel | Cotrimhexal | Cotrimol |
Cotrimox | Cotrimoxazol | Cotrimoxin | Cotrimstada | Cotripharm | Cotrisul | Cotrixyl-L | Cotrizol |
Cotrizole | Cots | Cozol | Cozole | Creptrim | Curaprim | Daiphen | Decatrim |
Deotrim | Dertrin | Dhatrin | Dino-BAC | Diseptyl | Doctrim | Dosatran | Drilozole |
Drossul | Droxol | Drylin | Dubac | Dumotrim | Duobact | Duobiocin | Duoctrin |
DUO Septol | Duratrimet | Dutran | Dvaseptol | Dynaprim | Ectaprim | Ectrin | Editrim |
Eduprim | Eliprim | Eroprim | Erotrim | Erphatrim | Esbesul | Escoprim | Espectrin |
Espectroprima | Ethitrim | Eurotrim | Eusaprim | Eutrim | Exazol | Fabubac | Fakzol |
Falprim | Fameprim | Fectrim | Fedimed | Fisat | Flatran | Flocot | Forcrim |
Forteprim | Gamactrin | Gatrima | Genoctrin | Genoxzole | Gentrim | Genzaprim | Getrim |
Globaxol | Gobens Trim | Graprima | Groseptol | Gunametrim | Hatrix | Helveprim | Herixina |
Hexaprim | Hicot | Hufacid | Huma-Trimel | Ibtrim | Imcotran | Imexim | Inatrim |
Infatrim | Infectran | Infectrim | Infectrin | Infesin | Intrafort | Introcin | Irgagen |
Isoprim | Isotrim | Japtrim | Jasotrim | Jenamoxazol | Jestrim | Justeprim | K.B.famate |
Kaftrim | Kathrex | Katrim | Kaytran | Kemocid | Kemoprim | Kentricid | Kepinol |
Kindoprim | KO-Kure | Kombina | Kotazol | Kotrimoksazol | Krobactrol | L-Trim | Lacreozole |
Lagatrim | Lapikot | Laratrim | Larprim | Lastrim | Leotrim | Leprim | Lescot |
Letus | Lictora | Lifactrin | Lifzol | Lisaprin | Litrim | Lobact | Longasal |
Lupectrin | Lusaprim | Lykaprim | M-Moxa | M-Trim | Macprim | Macromed | Mactran |
Madroxin | Maktrim | Martiprim | Maxaprim | Maxiprim | Maxitrin | Maxol | Maxtrim |
Maxzol | Mazatrim | Mebryn | Medcotrim | Mediprim | Meditran | Meditrim | Medtrim |
Megabroncoflam | Megaset | Megatrim | Meprim | Meprotrin | Methoprim | Methotrin | Metoprim |
Metoprin | Metoxiprim | Metrim | Metxaprim | Mexaprim | Mexazole | Mezenol | Micinovo |
Micogyl | Microbid | Microcetim | Microdyn | Microsupos Amigdalar | Microtrim | Mikotrim | Mikrosid |
Miratrim | Moly | Mortin | Moxadden | Moxalas | Moxatrim | Moxzole | Mukadryl |
Myctrim | Naftran | Napatrim | Navatrim | Necorzole | Neoset | Neotrim | Netocur |
Neuroprim | Nicotrim | Nilium | Nodilon | Nopil | Norisep | Nortrim | Nortrime |
Notrim | Notrime | Novactil | Novidrine | Novotrimel | Novotrimox | Novotrim Plus | Novozole |
Nucotrim | Nufaprim | Nuruzole | Octil-S | Octran | Octrim | Oecotrim | Okatrim |
Omegtrim | Omnatrim | Omsat | Onetrim | Oradin | Orbak | Orgastran | Oribact |
Ormoprim | Ostrin Forte | Otrim | Ottoprim | Oxaprim | Pakzole | Pantrim | Patrim |
Pehatrim | Penetrin | Pentrin | Penzole | Pharmatrim | Pharmazol | Phartex | Pisatrina |
Plurisul | Polibatrin | Politrim | Polytran | Pribac | Primadex | Primasul | Primasulf |
Primatrim | Primavon | Primazol | Primazole | Primotren | Primox | Primsulfon | Primzole |
Protrin | Pulkrin | Purbac | Qiftrim | Qiftrin | Quimio-PED | Quisulyn | Rancotrim |
Rasat | Raseptol | Ratrim | Regtin | Rematrim | Renatrim | Resprim | Retrim |
Rexaprim | Ribatrim | Rimazole | Rimezone | Rivoprim | Rizol | Rolprim | Roubac |
Roxtrim | Roytrin | Salgatran | Saltrim | Sanprima | Saptrim | Satrim | Sbpa Trimeth Smeth |
Scribcin | Seematrim | Seftrim | Selectrin | Semozol | Sepiran | Sepmax | Septabid |
Septazol | Septazole | Septerin | Septinix | Septiolan | Septocid R + | Septoprin | Septra |
Septran | Septrin-S | Septrin Paediatric | Servitrim | Sigaprim | Sigatrim | Silpin | Siltran |
Sinatrim | Sinersul | Sinotrim | Sisoprim | Sistrim | Sitrim | Skytrin | Smartrim |
Soltrim | Soptrim | Sosetran | Spectrem | Spectrim | Stan | Stopan | Strim |
Suftrex | Sulbacta | Sulfagrand | Sulfamer | Sulfamet | Sulfamethoprim | Sulfametoxazol | Sulfaprim |
Sulfarim | Sulfatalpin | Sulfaton | Sulfatrim | Sulfatropim | Sulfawal-T | Sulfinam | Sulfoid Trimetho |
Sulfometh | Sulfonamide | Sulfort | Sulfotrim | Sulfotrimin | Sulftran | Sulgotri | Sulotrim |
Sulphaprim | Sulphathoprim | Sulphatran | Sulphatrim | Sulphax | Sulphytrim Forte | Sulprim | Sulprimed |
Sultase | Sulthrim | Sultiprim | Sultorim | Sultra | Sultrex | Sultrim | Sultrima |
Sultrimmix | Sultrivon-F | Sultropim | Sumetoprim | Sumetrolim | Sumetrolin | Sumitran | Suntrim |
Supim | Supracombin | Suprasulf | Suprex | Supribac | Suprim | Suprimass | Suprin |
Suptrex | Suptrim | Sutaprim | Sutrim | Sutrisan | Suxprim | Syltrifil | Synac |
Synastat | Synbac | Synco-Smzt | Syndal | Synermed | Synerzole | Synetra | Synotrim |
Syntoprim | System | Tabrol | Tagremin | Teof | Terasulf | Terbosulfa | Teutrin |
Theraprim | Therasept | Theratrim | Thoprim | Thriazol | Torrid | Tprim | Trelibec |
Trib | Tricban | Tricomox | Tricot | Trifides | Triforam | Trihexal | Trim |
Trima | Trimaxazole | Trimel | Trimephar | Trimeran | Trimerazin | Trimeril | Trimesol |
Trimesul | Trimesulf | Trimeta | Trimethox | Trimetoger | Trimetop Duplo | Trimetotal | Trimetox |
Trimetrin | Trimetsol | Trimexasol | Trimexazol | Trimexazole | Trimexole-F | Trimezol | Trimezole |
Trimfasul | Trimidar M | Triminex | Trimocom | Trimoks | Trimosul | Trimosulfa | Trimoxavin |
Trimoxazol | Trimoxazole-BC | Trimoxin | Trimoxis | Trimoxsul | Trimozol | Trimsul | Trimzol |
Triphimox | Tripur | Trisep | Trisfides | Trisolak Forte | Trisolvat | Trisul | Trisulcom |
Trisulfa | Trisulfose | Trisuprim | Trisural | Tritenk | Tritosul | Trixazol | Trixzol |
Trizole | Tryseptolum | Tytrim | U-Prin | Ulfaprim | Ultrasept | Ultrazole | Ultrim |
Unitran | Uprina | Urethrax | Urodown | Uroplus DS | Urtium | Utrin | Versatrim |
Virin | Weiditrin | Wiatrim | Wiltran | Wypal | X-Trim | XA-Zole | Xazotrim |
Xepaprim | Xerazole | Xeroprim | Yekaprim | Zactron | Zamboprim | Zantran | Zaxol |
Zecatrim | Zeptra | Zerrprim | Zolebid | Zolmed | Zoltrijem | Zoltrim | Zultrop |