Difference between revisions of "Pentamidine (Nebupent)"
(Created page with "==General information== Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019887s014lbl.pdf Pentamidine (Nebupent) package insert]</re...") |
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| + | Also known as pentamidine isethionate, Pentam. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019887s014lbl.pdf Pentamidine (Nebupent) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/pentamidine.pdf Pentamidine (Nebupent) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019887s014lbl.pdf Pentamidine (Nebupent) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/pentamidine.pdf Pentamidine (Nebupent) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: inhaled, IM, IV |
| − | <br>Extravasation: | + | <br>Extravasation: no information |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 17:10, 24 February 2012
Also known as pentamidine isethionate, Pentam.
General information
Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.[1][2]
Route: inhaled, IM, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].