Difference between revisions of "Deferoxamine (Desferal)"
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==General information== | ==General information== | ||
Class/mechanism: Iron chelating agent; chelates iron from ferritin and hemosiderin but not easily from | Class/mechanism: Iron chelating agent; chelates iron from ferritin and hemosiderin but not easily from | ||
| − | transferrin. Does not combine with iron from hemoglobin and cytochromes. The chelate is soluble in water and is excreted by the kidney (as well as the bile), which causes urine to appear reddish.<ref name="insert">[http://www.pharma.us.novartis.com/product/pi/pdf/desferal.pdf Deferoxamine (Desferal) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/ | + | transferrin. Does not combine with iron from hemoglobin and cytochromes. The chelate is soluble in water and is excreted by the kidney (as well as the bile), which causes urine to appear reddish.<ref name="insert">[http://www.pharma.us.novartis.com/product/pi/pdf/desferal.pdf Deferoxamine (Desferal) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/deferoxamine.pdf Deferoxamine (Desferal) package insert (locally hosted backup)]</ref> |
<br>Route: IM, SC, IV | <br>Route: IM, SC, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
Revision as of 20:56, 22 February 2012
General information
Class/mechanism: Iron chelating agent; chelates iron from ferritin and hemosiderin but not easily from
transferrin. Does not combine with iron from hemoglobin and cytochromes. The chelate is soluble in water and is excreted by the kidney (as well as the bile), which causes urine to appear reddish.[1][2]
Route: IM, SC, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].