Difference between revisions of "Pentamidine (Nebupent)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019887s014lbl.pdf Pentamidine (Nebupent) package insert]</ref><ref>[ | + | Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019887s014lbl.pdf Pentamidine (Nebupent) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/pentamidine.pdf Pentamidine (Nebupent) package insert (locally hosted backup)]</ref> |
<br>Route: inhaled, IM, IV | <br>Route: inhaled, IM, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
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[[Category:PCP prophylaxis]] | [[Category:PCP prophylaxis]] | ||
| − | [[Category: | + | [[Category:FDA approved in 1989]] |
Revision as of 19:27, 23 June 2024
General information
Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.[1][2]
Route: inhaled, IM, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
Also known as
- Generic name: pentamidine dimesilate
- Brand names: Benambax, Lomidine, Nebupent, Pentam, Pentamidina, Pneumopent