Difference between revisions of "Retifanlimab (Zynyz)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
− | *2023-03-22: Granted accelerated approval for adult patients with metastatic or recurrent locally advanced [[Merkel cell carcinoma|Merkel cell carcinoma (MCC)]]. ''(Based on | + | *2023-03-22: Granted accelerated approval for adult patients with metastatic or recurrent locally advanced [[Merkel cell carcinoma|Merkel cell carcinoma (MCC)]]. ''(Based on POD1UM-201)'' |
==Also known as== | ==Also known as== |
Latest revision as of 15:06, 25 December 2023
Mechanism of action
From NCI Drug Dictionary: A proprietary humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T cells and cell-mediated immune responses against tumor cells.
Diseases for which it is used
History of changes in FDA indication
- 2023-03-22: Granted accelerated approval for adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma (MCC). (Based on POD1UM-201)
Also known as
- Code name: INCMGA 0012, MGA 012
- Generic name: retifanlimab-dlwr
- Brand name: Zynyz