Difference between revisions of "Tivozanib (Fotivda)"
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==Diseases for which it is established== | ==Diseases for which it is established== | ||
*[[Renal cell carcinoma]] | *[[Renal cell carcinoma]] | ||
+ | **[[Clear cell renal cell carcinoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
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*[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]</ref> | ||
− | ==History of changes in FDA | + | ==History of changes in FDA indication== |
− | * | + | *2021-03-10: Approved for adult patients with relapsed or refractory advanced [[renal cell carcinoma|renal cell carcinoma (RCC)]] following two or more prior systemic therapies. ''(Based on TIVO-3)'' |
+ | ==History of changes in EMA indication== | ||
+ | *2017-08-24: Initial authorization for first line treatment of adult patients with advanced [[renal cell carcinoma|renal cell carcinoma (RCC)]]. ''(Based on TIVO-1)'' | ||
+ | *2017-08-24: Initial authorization for adult patients who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment with cytokine therapy for advanced [[renal cell carcinoma|RCC]]. ''(Based on TIVO-1)'' | ||
==Also known as== | ==Also known as== | ||
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[[Category:VEGFR inhibitors]] | [[Category:VEGFR inhibitors]] | ||
+ | [[Category:Clear cell renal cell carcinoma medications]] | ||
[[Category:Renal cell carcinoma medications]] | [[Category:Renal cell carcinoma medications]] | ||
− | [[Category:EMA approved | + | [[Category:EMA approved in 2017]] |
+ | [[Category:FDA approved in 2021]] |
Revision as of 00:29, 7 November 2023
Mechanism of action
From the NCI Drug Dictionary: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.[1][2][3]
Diseases for which it is established
Patient drug information
History of changes in FDA indication
- 2021-03-10: Approved for adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. (Based on TIVO-3)
History of changes in EMA indication
- 2017-08-24: Initial authorization for first line treatment of adult patients with advanced renal cell carcinoma (RCC). (Based on TIVO-1)
- 2017-08-24: Initial authorization for adult patients who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment with cytokine therapy for advanced RCC. (Based on TIVO-1)
Also known as
- Code name: AV-951
- Brand name: Fotivda