Difference between revisions of "Vindesine (Eldisine)"
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Warner-admin (talk | contribs) m (Text replacement - "Adult T-cell leukemia-lymphoma" to "Adult T-cell leukemia/lymphoma") |
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==General information== | ==General information== | ||
| − | Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.<ref name="insert">[http://www.bccancer.bc.ca/NR/rdonlyres/D6279B9B-2F71-4784-8AF8-D1452648635C/19507/Vindesinemonograph_3Nov07.pdf Vindesine (Eldisine) package insert]</ref><ref>[[ | + | Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.<ref name="insert">[http://www.bccancer.bc.ca/NR/rdonlyres/D6279B9B-2F71-4784-8AF8-D1452648635C/19507/Vindesinemonograph_3Nov07.pdf Vindesine (Eldisine) package insert]</ref><ref>[[:File:Vindesine.pdf | Vindesine (Eldisine) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] | <br>Extravasation: [[vesicant]] | ||
| Line 9: | Line 9: | ||
==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *[[Adult T-cell leukemia | + | *[[Adult T-cell leukemia-lymphoma]] |
*[[Burkitt lymphoma]] | *[[Burkitt lymphoma]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
| Line 15: | Line 15: | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
*[[Melanoma]] | *[[Melanoma]] | ||
| + | *[[Neuroblastoma]] | ||
*[[Non-small cell lung cancer]] | *[[Non-small cell lung cancer]] | ||
*[[Post-transplant lymphoproliferative disorder]] | *[[Post-transplant lymphoproliferative disorder]] | ||
| − | *[[Small cell lung cancer]] | + | |
| + | ==Diseases for which it was used== | ||
| + | *[[Acute myeloid leukemia - historical|Acute myeloid leukemia]] | ||
| + | *[[Small cell lung cancer - historical|Small cell lung cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| Line 24: | Line 28: | ||
*[http://www.uptodate.com/contents/vindesine-patient-drug-information Vindesine (Eldisine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vindesine-patient-drug-information Vindesine (Eldisine) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/vindesine-patient-drug-information Vindesine (Eldisine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vindesine-patient-drug-information Vindesine (Eldisine) patient drug information (UpToDate)]</ref> | ||
| + | ==History of changes in EMA indication== | ||
| + | *1979-04-11: EURD | ||
==Also known as== | ==Also known as== | ||
*'''Code name:''' LY-099094 | *'''Code name:''' LY-099094 | ||
*'''Generic names:''' desacetylvinblastine amide, DAVA, DVA, VDS | *'''Generic names:''' desacetylvinblastine amide, DAVA, DVA, VDS | ||
| − | *'''Brand names:''' Eldesine, Eldisin, Enison, Fildesin, Gesidine | + | *'''Brand names:''' Eldesine, Eldisin, Eldisine, Enison, Fildesin, Gesidine |
==References== | ==References== | ||
| Line 34: | Line 40: | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
| − | [[Category:Vesicant | + | [[Category:Vesicant]] |
[[Category:Microtubule inhibitors]] | [[Category:Microtubule inhibitors]] | ||
[[Category:Vinca alkaloids]] | [[Category:Vinca alkaloids]] | ||
| − | [[Category:Adult T-cell leukemia | + | [[Category:Adult T-cell leukemia-lymphoma medications]] |
[[Category:Burkitt lymphoma medications]] | [[Category:Burkitt lymphoma medications]] | ||
[[Category:CNS lymphoma medications]] | [[Category:CNS lymphoma medications]] | ||
| Line 45: | Line 51: | ||
[[Category:HIV-associated lymphoma medications]] | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Melanoma medications]] | [[Category:Melanoma medications]] | ||
| + | [[Category:Neuroblastoma medications]] | ||
[[Category:Non-small cell lung cancer medications]] | [[Category:Non-small cell lung cancer medications]] | ||
[[Category:Post-transplant lymphoproliferative disorder medications]] | [[Category:Post-transplant lymphoproliferative disorder medications]] | ||
| − | [[Category:Small cell lung cancer medications]] | + | |
| + | [[Category:Acute myeloid leukemia medications (historic)]] | ||
| + | [[Category:Small cell lung cancer medications (historic)]] | ||
| + | |||
| + | [[Category:EMA approved in 1979]] | ||
Revision as of 00:22, 7 November 2023
Not approved by the FDA. Approved for use in some countries e.g., U.K., South Africa.
General information
Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Adult T-cell leukemia-lymphoma
- Burkitt lymphoma
- CNS lymphoma
- Diffuse large B-cell lymphoma
- HIV-associated lymphoma
- Melanoma
- Neuroblastoma
- Non-small cell lung cancer
- Post-transplant lymphoproliferative disorder
Diseases for which it was used
Patient drug information
- Vindesine (Eldisine) patient information at Macmillan Cancer Support[3]
- Vindesine (Eldisine) patient information at Genus Pharmaceuticals[4]
- Vindesine (Eldisine) patient drug information (UpToDate)[5]
History of changes in EMA indication
- 1979-04-11: EURD
Also known as
- Code name: LY-099094
- Generic names: desacetylvinblastine amide, DAVA, DVA, VDS
- Brand names: Eldesine, Eldisin, Eldisine, Enison, Fildesin, Gesidine
References
- ↑ 1.0 1.1 Vindesine (Eldisine) package insert
- ↑ Vindesine (Eldisine) package insert (locally hosted backup)
- ↑ Vindesine (Eldisine) patient information at Macmillan Cancer Support
- ↑ Vindesine (Eldisine) patient information at Genus Pharmaceuticals
- ↑ Vindesine (Eldisine) patient drug information (UpToDate)
Categories:
- Drugs
- Intravenous medications
- Vesicant
- Microtubule inhibitors
- Vinca alkaloids
- Adult T-cell leukemia-lymphoma medications
- Burkitt lymphoma medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- HIV-associated lymphoma medications
- Melanoma medications
- Neuroblastoma medications
- Non-small cell lung cancer medications
- Post-transplant lymphoproliferative disorder medications
- Acute myeloid leukemia medications (historic)
- Small cell lung cancer medications (historic)
- EMA approved in 1979