Difference between revisions of "Methotrexate (MTX)"

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[[Category:Bladder cancer medications]]
 
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[[Category:Bone cancer medications]]  
 
[[Category:Breast cancer medications]]
 
[[Category:Breast cancer medications]]
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[[Category:Burkitt lymphoma medications]]
 
[[Category:Central nervous system (CNS) lymphoma medications]]
 
[[Category:Central nervous system (CNS) lymphoma medications]]
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[[Category:Diffuse large B-cell lymphoma medications]]
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[[Category:Extranodal NK/T-cell lymphoma, nasal type medications]]
 
[[Category:Head and neck cancer medications]]
 
[[Category:Head and neck cancer medications]]
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[[Category:Hemophagocytic lymphohistiocytosis medications]]
 
[[Category:HIV-associated lymphoma medications]]
 
[[Category:HIV-associated lymphoma medications]]
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[[Category:Large granular lymphocytic leukemia medications]]
 
[[Category:Mantle cell lymphoma medications]]
 
[[Category:Mantle cell lymphoma medications]]
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[[Category:NK/T-cell lymphoma medications]]
 
[[Category:Penile cancer medications]]  
 
[[Category:Penile cancer medications]]  
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[[Category:Peripheral T-cell lymphoma medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]
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[[Category:T-cell lymphoma medications]]
 
 
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[[Category:Drugs FDA approved in 1953]]
 
[[Category:Drugs FDA approved in 1953]]

Revision as of 02:07, 14 May 2015

General information

Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2]
Route: IV, PO, IM, IT, intraarterial
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

Also known as

Synonyms
Abitrexate Alltrex Amethopterin Antifolan APO-Methotrexate Artrait Biometrox Biotrexate
Caditrex Cytotrexate Ebetrexat Emthexat Emthexate Emthexate PF Emthexate S Ervemin
Farmitrexat Fauldmetro Folex PFS Folitrax Hextrate Ifamet Imutrex,Ledertrexate Ledertrexate Sodium
Ledertrexato Lumexon Matrex Maxtrex Medsatrexate Merex Metex Methobax
Methoblastin Methorex Methotrexaat Methotrexaat Sandoz Methotrexat Biosyn Methotrexat Ebewe Methotrexate Bigmar Methotrexate Bristol
Methotrexate DBL Methotrexate Disodium Methotrexate DUP Methotrexate Ebewe Methotrexate Farmos Methotrexate Knoll Methotrexate Lederle Methotrexate LPF
Methotrexate Mayne Methotrexate Merck Methotrexate Paranova Methotrexate R Methotrexate Remedica Methotrexate Singad Methotrexate Sodium Methotrexate Sodium Lederle
Methotrexate Teva Methotrexate Wyeth Methotrexat Lederle Methotrexat Medac Methotrexato Methotrexat Ridupharm Methotrexat Teva Methotrexatum
Meticil Metolate Metotressato Metotrexate Metotrexato Asofarma Metotrexato Chiesi Metotrexato Dosa Metotrexato Filaxis
Metotrexato Lederle Metotrexato Martian Metotrexato Microsules Metotrexol Metrex Metrexan Metrexato Metrotex
Mexate Miantrex CS MTX MTX Hexal Neometho Neotrexate Novatrex Oncotrex
Oncotrex-PF O Trexat P&U Methotrexate Pharmatrexate Ratio-Methotrexate Remtrex Reumatrex Rextop
Rheumatrex Tecnomet Texate Texate T Texorate Tratoben Trav Methotrexate Tremetex
Trexall Trexan Trexeron Trixilem Trixilem RU Unitrexate Vero Methotrexate Zexate

History of changes in FDA indication

  • 12/7/1953: Initial FDA approval

References

  1. ↑ 1.0 1.1 Methotrexate (MTX) package insert
  2. ↑ Methotrexate (MTX) package insert (locally hosted backup)
  3. ↑ Methotrexate (MTX) patient drug information (Chemocare)
  4. ↑ Methotrexate (MTX) patient drug information (UpToDate)
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