Difference between revisions of "Vadimezan (AS-A404)"
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(Created page with "==Mechanism of action== From the NCI Drug Dictionary: A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines...") |
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==Mechanism of action== | ==Mechanism of action== | ||
| − | From the NCI Drug Dictionary: A fused tricyclic | + | From the [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/vadimezan NCI Drug Dictionary]: A fused tricyclic analog of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. |
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| + | ==Diseases for which is was unsuccessful== | ||
| + | *[[Non-small cell lung cancer - historical|Non-small cell lung cancer]] | ||
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| + | ==Also known as== | ||
| + | *'''Code names:''' AS-1404, AS-A404 | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
| + | [[Category:Intravenous medications]] | ||
[[Category:Vascular disrupting agents]] | [[Category:Vascular disrupting agents]] | ||
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[[Category:Investigational drugs]] | [[Category:Investigational drugs]] | ||
[[Category:Stub]] | [[Category:Stub]] | ||
Latest revision as of 16:49, 1 October 2023
Mechanism of action
From the NCI Drug Dictionary: A fused tricyclic analog of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
Diseases for which is was unsuccessful
Also known as
- Code names: AS-1404, AS-A404