How I Treat

The "How I Treat" series has been published by Blood for several decades and covers a wide variety of topics in malignant and classical hematology. While these articles are not considered to be formal guidelines, they are considered high-level expert opinion. They cover topics ranging from commonly encountered hematologic conditions with a large evidence base, to very rare conditions with only case reports to guide treatment. The purpose of this page is to consolidate the links to all known published How I Treat articles.

Articles are presented by condition, in reverse chronological order. Given the rapid change in evidence in many areas of hematology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

Note: this page is currently under construction.

Malignant hematology

Myeloid neoplasms

Acute lymphoblastic leukemia (ALL)

• 2023: Kopmar & Cassaday. How I prevent and treat central nervous system disease in adults with acute lymphoblastic leukemia PubMed
• 2023: Myers et al. How I use risk factors for success or failure of CD19 CAR T cells to guide management of children and AYA with B-cell ALL PubMed
• 2023: Si Lim et al. How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults PubMed
• 2020: Aldoss & Douer. How I treat the toxicities of pegasparaginase in adults with acute lymphoblastic leukemia PubMed
• 2020: Aldoss & Forman. How I treat adults with advanced acute lymphoblastic leukemia eligible for CD19-targeted immunotherapy PubMed
• 2020: Hunger & Raetz. How I treat relapsed acute lymphoblastic leukemia in the pediatric population PubMed
• 2020: Teachey & O'Connor How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children PubMed
• 2019: Ravandi. How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia PubMed
• 2015: Curran & Stock. How I treat acute lymphoblastic leukemia in older adolescents and young adults PubMed
• 2015: Frey & Luger. How I treat adults with relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia PubMed

Acute myeloid leukemia (AML)

• 2023: Biederstädt & Rezvani. How I treat high-risk acute myeloid leukemia using preemptive adoptive cellular immunotherapy PubMed
• 2021: Falini et al. How I diagnose and treat NPM1-mutated AML PubMed
• 2021: Rubnitz & Kaspers. How I treat pediatric acute myeloid leukemia PubMed
• 2020: DeWolf & Tallman. How I treat relapsed or refractory AML PubMed
• 2020: DiNardo & Wei. How I treat acute myeloid leukemia in the era of new drugs PubMed
• 2016: Ofran et al. How I treat acute myeloid leukemia presenting with preexisting comorbidities PubMed
• 2015: Röllig & Ehninger. How I treat hyperleukocytosis in acute myeloid leukemia PubMed
• 2014: Ossenkoppele & Löwenberg. How I treat the older patient with acute myeloid leukemia PubMed
• 2011: Bakst et al. How I treat extramedullary acute myeloid leukemia PubMed

Chronic myeloid leukemia (CML)

• 2022: Berman. How I treat chronic-phase chronic myelogenous leukemia
• 2019: Hijiya & Suttorp. How I treat chronic myeloid leukemia in children and adolescents

Myelodysplastic syndrome (MDS)

• 2019: Santini How I treat MDS after hypomethylating agent failure
• 2013: Sekeres & Cutler How we treat higher-risk myelodysplastic syndromes PubMed
• 2013: Fenaux & Adès How we treat lower-risk myelodysplastic syndromes

Polycythemia vera (PV)

• 2014: Vannucchi How I treat polycythemia vera PubMed

Lymphoid neoplasms

Adult T-cell leukemia-lymphoma (ATLL)

• 2021: Cook & Phillips How I treat adult T-cell leukemia/lymphoma PubMed

Castleman disease

• 2010: Bower. How I treat HIV-associated multicentric Castleman disease PubMed

Chronic lymphocytic leukemia (CLL/SLL)

• 2021: Lew et al. How I treat chronic lymphocytic leukemia after venetoclax
• 2019: Stephens & Byrd. How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia
• 2018: Brown. How I treat CLL patients with ibrutinib PubMed

Cutaneous T-cell lymphoma (CTCL)

• 2019: Shinohara & Shustov How I treat primary cutaneous CD30 + lymphoproliferative disorders

Hodgkin lymphoma

• 2021: Epperla & Herrera How I incorporate novel agents into the treatment of classical Hodgkin lymphoma
• 2020: Eichenauer & Engert How I treat nodular lymphocyte-predominant Hodgkin Lymphoma

Diffuse large B-cell lymphoma (DLBCL)

• 2023: Lugtenburg & Mutsaers How I treat older patients with DLBCL in the frontline setting PubMed

Follicular lymphoma (FL)

• 2019: Casulo & Barr How I treat early-relapsing follicular lymphoma PubMed

Large granular lymphocytic leukemia (T-LGL)

• 2011: Lamy & Loughran. How I treat LGL leukemia PubMed

NK- and T-cell lymphoma

• 2013: Tse & Kwong How I treat NK/T-cell lymphomas PubMed

Prolymphocytic leukemia (T-PLL)

• 2012: Dearden How I treat prolymphocytic leukemia PubMed

Waldenström macroglobulinemia (WM)

• 2019: Dimopoulos & Kastritis. How I treat Waldenström macroglobulinemia PubMed

Plasma cell dyscrasias

Light-chain (AL) amyloidosis

• 2022: Palladini & Merlini How I treat AL amyloidosis

Multiple myeloma

• 2023: van de Donk How We Manage Newly Diagnosed Multiple Myeloma With Circulating Tumor Cells
• 2022: Zamagni et al. How I treat high-risk multiple myeloma
• 2022: Kastritis et al. How I treat relapsed multiple myeloma
• 2022: Vaxman & Gertz How I approach smoldering multiple myeloma

Histiocytic disorders

Hemophagocytic lymphohistiocytosis (HLH)

• 2015: Schram & Berliner. How I treat hemophagocytic lymphohistiocytosis in the adult patient PubMed