Difference between revisions of "Sorafenib Dosing Nomogram"

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<big>''This page contains studies that were specific to pediatric populations. For the more general AML page, follow [[Acute myeloid leukemia|this link]].</big>
 
 
{| class="wikitable" style="float:right; margin-right: 5px;"
 
{| class="wikitable" style="float:right; margin-right: 5px;"
 
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=AAML1031 Sorafenib Dosing Nomogram=
 
=AAML1031 Sorafenib Dosing Nomogram=
−
 
+
''Note: BSA is rounded to the hundredth place.''
−
{| class="wikitable" style="width: 40%; text-align:center;"  
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{| class="wikitable" style="width: 80%; text-align:center;"  
 
! style="width: 25%" |BSA Range (m<sup>2</sup>)
 
! style="width: 25%" |BSA Range (m<sup>2</sup>)
 
! style="width: 25%" |Dose Level 0 (100 mg/m<sup>2</sup>/day once daily)
 
! style="width: 25%" |Dose Level 0 (100 mg/m<sup>2</sup>/day once daily)
 
! style="width: 25%" |Dose Level 1 (200 mg/m<sup>2</sup>/day once daily)
 
! style="width: 25%" |Dose Level 1 (200 mg/m<sup>2</sup>/day once daily)
−
! style="width: 25%" |Dose Level 2 (300 mg/m<sup>2</sup>/day divided BID)
+
! style="width: 25%" |Dose Level 2 (300 mg/m<sup>2</sup>/day divided twice per day)
 
|-
 
|-
−
|≤ 0.35
+
|Less than or equal to 0.35
 
|50 mg x 4 days/week,
 
|50 mg x 4 days/week,
 
0 x 3 day/week
 
0 x 3 day/week
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100 mg x 2 days/week
 
100 mg x 2 days/week
 
(450 mg)
 
(450 mg)
−
|50 mg twice daily x 7 days/week
+
|50 mg twice per day x 7 days/week
 
(700 mg)
 
(700 mg)
 
|-
 
|-
−
|0.36 - 0.4
+
|0.36 to 0.40
 
|50 mg x 5 days/week,
 
|50 mg x 5 days/week,
 
0 x 2 day/week
 
0 x 2 day/week
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100 mg x 3 days/week
 
100 mg x 3 days/week
 
(500 mg)
 
(500 mg)
−
|50 mg twice daily x 6 days/week +
+
|50 mg twice per day x 6 days/week +
−
100 mg twice daily x 1 day/week
+
100 mg twice per day x 1 day/week
 
(800 mg)
 
(800 mg)
 
|-
 
|-
−
|0.41 - 0.45
+
|0.41 to 0.45
 
|50 mg x 6 days/week,
 
|50 mg x 6 days/week,
 
0 x 1 day/week
 
0 x 1 day/week
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100 mg x 5 days/week
 
100 mg x 5 days/week
 
(600 mg)
 
(600 mg)
−
|50 mg twice daily x 5 days/week +
+
|50 mg twice per day x 5 days/week +
−
100 mg twice daily x 2 days/week
+
100 mg twice per day x 2 days/week
 
(900 mg)
 
(900 mg)
 
|-
 
|-
−
|0.46 - 0.55
+
|0.46 to 0.55
 
|50 mg x 7 days/week
 
|50 mg x 7 days/week
 
(350 mg)
 
(350 mg)
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(1050 mg)
 
(1050 mg)
 
|-
 
|-
−
|0.56 - 0.6
+
|0.56 to 0.60
 
|50 mg x 6 days/week,
 
|50 mg x 6 days/week,
 
100 mg x 1 day/week
 
100 mg x 1 day/week
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200 mg x 1 day/week
 
200 mg x 1 day/week
 
(800 mg)
 
(800 mg)
−
|50 mg twice daily x 2 days/week +
+
|50 mg twice per day x 2 days/week +
−
100 mg twice daily x 5 days/week
+
100 mg twice per day x 5 days/week
 
(1200 mg)
 
(1200 mg)
 
|-
 
|-
−
|0.61 - 0.7
+
|0.61 to 0.70
 
|50 mg x 5 days/week,
 
|50 mg x 5 days/week,
 
100 mg x 2 days/week
 
100 mg x 2 days/week
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200 x 2 days/week
 
200 x 2 days/week
 
(900 mg)
 
(900 mg)
−
|100 mg twice daily x 7 days/week
+
|100 mg twice per day x 7 days/week
 
(1400 mg)
 
(1400 mg)
 
|-
 
|-
−
|0.71 - 0.8
+
|0.71 to 0.80
 
|50 mg x4 days/week,
 
|50 mg x4 days/week,
 
100 mg x3 days/week
 
100 mg x3 days/week
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|150 mg x 7 days/week
 
|150 mg x 7 days/week
 
(1050mg)
 
(1050mg)
−
|100 mg twice daily x 5 days/week +
+
|100 mg twice per day x 5 days/week +
−
150 mg twice daily x 2 days/week
+
150 mg twice per day x 2 days/week
 
(1600 mg)
 
(1600 mg)
 
|-
 
|-
−
|0.81 - 0.9
+
|0.81 to 0.90
 
|50 mg x 2 days/week,
 
|50 mg x 2 days/week,
 
100 mg x 5 days/week
 
100 mg x 5 days/week
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(1750 mg)
 
(1750 mg)
 
|-
 
|-
−
|0.91 - 01.05
+
|0.91 to 1.05
 
|100 mg x 7 days/week
 
|100 mg x 7 days/week
 
(700 mg)
 
(700 mg)
 
|200 mg x 7 days/week
 
|200 mg x 7 days/week
 
(1400 mg)
 
(1400 mg)
−
|150 mg twice daily x 7 days/week
+
|150 mg twice per day x 7 days/week
 
(2100 mg)
 
(2100 mg)
 
|-
 
|-
−
|1.06 - 1.2
+
|1.06 to 1.20
 
|100 mg x 6 days/week,
 
|100 mg x 6 days/week,
 
200 mg x1 day/week
 
200 mg x1 day/week
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(2450 mg)
 
(2450 mg)
 
|-
 
|-
−
|1.21 - 1.35
+
|1.21 to 1.35
 
|100 mg x 5 days/week,
 
|100 mg x 5 days/week,
 
200 mg x 2 days/week
 
200 mg x 2 days/week
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|250 mg x 7 days/week
 
|250 mg x 7 days/week
 
(1750 mg)
 
(1750 mg)
−
|200 mg twice daily x 7 days/week
+
|200 mg twice per day x 7 days/week
 
(2800 mg)
 
(2800 mg)
 
|-
 
|-
−
|1.36 - 1.6
+
|1.36 to 1.60
 
|100 mg x 4 days/week,
 
|100 mg x 4 days/week,
 
200 mg x 3 days/week
 
200 mg x 3 days/week
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(3150 mg)
 
(3150 mg)
 
|-
 
|-
−
|1.61 - 1.7
+
|1.61 to 1.70
 
|100 mg x 2 days/week,
 
|100 mg x 2 days/week,
 
200 mg x 5 days/week
 
200 mg x 5 days/week
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|350 mg x 7 days/week
 
|350 mg x 7 days/week
 
(2450 mg)
 
(2450 mg)
−
|250 mg twice daily x 7
+
|250 mg twice per day x 7
 
days/week
 
days/week
 
(3500 mg)
 
(3500 mg)
 
|-
 
|-
−
|1.71 - 1.85
+
|1.71 to 1.85
 
|100 mg x 1 day/week,
 
|100 mg x 1 day/week,
 
200 mg x 6 days/week
 
200 mg x 6 days/week
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(3850 mg)
 
(3850 mg)
 
|-
 
|-
−
|≥ 1.86
+
|1.86 or more
 
|200 mg x 7 days/week
 
|200 mg x 7 days/week
 
(1400 mg)
 
(1400 mg)
 
|400 mg x 7 days/week
 
|400 mg x 7 days/week
 
(2800 mg)
 
(2800 mg)
−
|300 mg twice daily x 7 days /week
+
|300 mg twice per day x 7 days /week
 
(4200 mg)
 
(4200 mg)
 
|}
 
|}
 +
 +
[[Category:General reference pages]]
 +
[[Category:Clinical pharmacology]]

Latest revision as of 20:21, 11 August 2023

Section editor
Noyd.png
 David Noyd, MD, MPH
University of Washington
Seattle, WA, USA
LinkedIn
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AAML1031 Sorafenib Dosing Nomogram

Note: BSA is rounded to the hundredth place.

BSA Range (m2) Dose Level 0 (100 mg/m2/day once daily) Dose Level 1 (200 mg/m2/day once daily) Dose Level 2 (300 mg/m2/day divided twice per day)
Less than or equal to 0.35 50 mg x 4 days/week,

0 x 3 day/week (200 mg)

50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

50 mg twice per day x 7 days/week

(700 mg)

0.36 to 0.40 50 mg x 5 days/week,

0 x 2 day/week (250 mg)

50 mg x 4 days/week,

100 mg x 3 days/week (500 mg)

50 mg twice per day x 6 days/week +

100 mg twice per day x 1 day/week (800 mg)

0.41 to 0.45 50 mg x 6 days/week,

0 x 1 day/week (300 mg)

50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

50 mg twice per day x 5 days/week +

100 mg twice per day x 2 days/week (900 mg)

0.46 to 0.55 50 mg x 7 days/week

(350 mg)

100 mg x 7 days/week

(700 mg)

50 mg q AM +100 mg q PM

x 7 days/week (1050 mg)

0.56 to 0.60 50 mg x 6 days/week,

100 mg x 1 day/week (400 mg)

100 mg x 6 days/week,

200 mg x 1 day/week (800 mg)

50 mg twice per day x 2 days/week +

100 mg twice per day x 5 days/week (1200 mg)

0.61 to 0.70 50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

100 mg x 5 days/week,

200 x 2 days/week (900 mg)

100 mg twice per day x 7 days/week

(1400 mg)

0.71 to 0.80 50 mg x4 days/week,

100 mg x3 days/week (500 mg)

150 mg x 7 days/week

(1050mg)

100 mg twice per day x 5 days/week +

150 mg twice per day x 2 days/week (1600 mg)

0.81 to 0.90 50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

150 mg x 4 days/week,

200 mg x 3 days/week (1200 mg)

100 mg q AM + 150 mg q PM

x 7 days/week (1750 mg)

0.91 to 1.05 100 mg x 7 days/week

(700 mg)

200 mg x 7 days/week

(1400 mg)

150 mg twice per day x 7 days/week

(2100 mg)

1.06 to 1.20 100 mg x 6 days/week,

200 mg x1 day/week (800 mg)

200

mg x 3 days/week, 250 mg x 4 days/week (1600 mg)

150 mg q AM + 200 mg q PM

x 7 days/week (2450 mg)

1.21 to 1.35 100 mg x 5 days/week,

200 mg x 2 days/week (900 mg)

250 mg x 7 days/week

(1750 mg)

200 mg twice per day x 7 days/week

(2800 mg)

1.36 to 1.60 100 mg x 4 days/week,

200 mg x 3 days/week (1000 mg)

300 mg x 7 days/week

(2100 mg)

200 mg q AM + 250 mg q PM

x 7 days/week (3150 mg)

1.61 to 1.70 100 mg x 2 days/week,

200 mg x 5 days/week (1200 mg)

350 mg x 7 days/week

(2450 mg)

250 mg twice per day x 7

days/week (3500 mg)

1.71 to 1.85 100 mg x 1 day/week,

200 mg x 6 days/week (1300 mg)

350 mg x 3 days/week

400 mg x 4 days/week (2650 mg)

250 mg q AM + 300 mg q PM

x 7 days/week (3850 mg)

1.86 or more 200 mg x 7 days/week

(1400 mg)

400 mg x 7 days/week

(2800 mg)

300 mg twice per day x 7 days /week

(4200 mg)

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